Effects of topical application of free and liposome-encapsulated lactoferrin and lactoperoxidase on oral microbiota and dental caries in rats

Archives of Oral Biology

Volumn 44, Issue 11, 1999, Pages 901-906

  Martinez Gomis J ^a   Fernandez Solanas A ^a   Vinas M ^a   Gonzalez P ^b   Planas, M E ^a   Sanchez S ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b San Guillem 21 E 08006   (Spain)

Author keywords

Dental caries; Lactoferrin; Lactoperoxidase; Liposome; Rat

Indexed keywords

ANTICARIES AGENT; DRUG CARRIER; FLUORIDE SODIUM; LACTOFERRIN; LACTOPEROXIDASE; LIPOSOME; PLACEBO;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; CARIOGENIC DIET; CONTROLLED STUDY; DENTAL CARIES; DISEASE MODEL; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; INCIDENCE; MICROBIOLOGY; MOUTH; MOUTH FLORA; NONHUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZATION; RAT; STATISTICAL ANALYSIS; STREPTOCOCCUS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS SOBRINUS; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANALYSIS OF VARIANCE; ANIMALS; CARIOSTATIC AGENTS; COLONY COUNT, MICROBIAL; DENTAL CARIES; DIET, CARIOGENIC; DISEASE MODELS, ANIMAL; DRUG CARRIERS; INCIDENCE; LACTOFERRIN; LACTOPEROXIDASE; LIPOSOMES; MOUTH; PLACEBOS; RANDOM ALLOCATION; RATS; SODIUM FLUORIDE; STREPTOCOCCUS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS SOBRINUS;

ANIMALIA; BACTERIA (MICROORGANISMS); MICROBIOTA; STREPTOCOCCUS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS SOBRINUS;

EID: 0345493872     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9969(99)00092-8     Document Type: Article

References (33)

1. Bellamy W., Takase M., Wakabayashi H., Kawase K., Tomita M. Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. J. Appl. Bacteriol. 73:1992;472-479.
2. Betageri G.V., Jenkins S.A., Parsons D.L. Liposome Drug Delivery Systems. 1993;Technomic, Lancaster.
3. Blackmore D., Green R.M. The use of germ-free and specific pathogen-free rats in short-term experiments for the assessment of cariogenic organisms. Archs. Oral Biol. 15:1970;1149-1155.
4. Carlsson J., Iwami Y., Yamada T. Hydrogen peroxide excretion by oral streptococci and effect of lactoperoxidase-thiocyanate-hydrogen peroxide. Infect. Immun. 40:1983;70-80.
5. Childers N.K., Zhang S.S., Harokopakis E., Harmon C.C., Michalek S.M. Properties of practical oral liposome-Streptococcus mutans glucosyltransferase vaccines for effective induction of caries protection. Oral Microbiol. Immunol. 11:1996;172-180.
6. Donoghue H.D., Hudson D.E., Perrons C.J. Effect of the lactoperoxidase system on streptococcal acid production and growth. J. Dent. Res. 66:1987;616-618.
7. Grahn E., Tenovuo J., Lehtonen O.P., Eerola E., Vilja P. Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults. Acta Odontol. Scand. 46:1988;67-74.
8. Gregoriadis G. Engineering liposomes for drug delivery: progress and problems. Trends Biotechnol. 13:1995;527-537.
9. 4F in rodents. Caries Res. 21:1987;346-352.
10. Jalil R.A., Ashley F.P., Wilson R.F., Wagaiyu E.G. Concentrations of thiocyanate, hypothiocyanite, free and total lysozyme, lactoferrin and secretory IgA in resting and stimulated whole saliva of children aged 12-14 years and the relationship with plaque accumulation and gingivitis. J. Periodont. Res. 28:1993;130-136.
11. Kalfas S., Andersson M., Edwardsson S., Forsgren A., Naidu A.S. Human lactoferrin binding to Porphyromonas gingivalis, Prevotella intermedia and Prevotella melaninogenica. Oral Microbiol. Immunol. 6:1991;350-355.
12. Kirstilä V., Häkkinen P., Jentsch H., Vilja P., Tenovuo J. Longitudinal analysis of the association of human salivary antimicrobial agents with caries increment and cariogenic micro-organisms: a two-year cohort study. J. Dent. Res. 77:1998;73-80.
13. Kirstilä V., Lenander-Lumikari M., Tenovuo J. Effects of a lactoperoxidase-system-containing toothpaste on dental plaque and whole saliva in vivo. Acta Odontol. Scand. 52:1994;346-353.
14. Lamberts B.L., Pruitt K.M., Pederson E.D., Golding M.P. Comparison of salivary peroxidase system components in caries free and caries active naval recruits. Caries Res. 18:1984;488-494.
15. Larson R.M. Merits and modifications of scoring rat dental caries by Keyes' method. Animal models in Cariology (Proceedings of a symposium on animal models in cariology). 1980;195-203 IRL Press, Washington DC.
16. Lassiter M.O., Newsome A.L., Sams L.D., Arnold R.R. Characterization of lactoferrin interaction with Streptococcus mutans. J. Dent. Res. 66:1987;480-485.
17. Lenander-Lumikari M., Tenovuo J., Mikola H. Effects of a lactoperoxidase system containing toothpaste on levels of hypothiocyanite and bacteria in saliva. Caries Res. 27:1993;285-291.
18. Lumikari M., Soukka T., Nurmio S., Tenovuo J. Inhibition of the growth of Streptococcus mutans, Streptococcus sobrinus and Lactobacillus casei by oral peroxidase systems in human saliva. Archs. Oral Biol. 36:1991;155-160.
19. Mandel I.D. Functions of saliva. J. Dent. Res. 66:1987;623-627.
20. Martínez-Gomis J., Planas M.E., Planelles X., Bartrons R., Sanchez S. Fluoride and pilocarpine reduce the risk of caries produced by chronic clomipramine treatment in rats. Caries Res. 31:1997;155-160.
21. Navia J.M. Animal Models in Dental Research. 1977;University of Alabama Press, Birmingham.
22. Nikawa H., Samaranayake L.P., Tenovuo J., Pang K.M., Hamada T. The fungicidal effect of human lactoferrin on Candida albicans and Candida krusei. Archs. Oral. Biol. 38:1993;1057-1063.
23. Planas M.E., Sánchez S., Gonzalez P., Rodrigues de Oliveira J., Bartrons R. Protective effect of fructose 1,6-bisphosphate against carrageenan-induced inflammation. Eur. J. Pharmacol. 237:1993;251-255.
24. Pol O., Planas M.E., Puig M.M. Effects of morphine and liposomal morphine in a model of intestinal inflammation in mice. Pharmacology. 53:1996;180-189.
25. Roger V., Tenovuo J., Lenander-Lumikari M., Söderling E., Vilja P. Lysozyme and lactoperoxidase inhibit the adherence of Streptococcus mutans NCTC 10449 (serotype c) to saliva treated hydroxyapatite in vitro. Caries Res. 28:1994;421-428.
26. Rölla G., Amsbaugh S.M., Monell-Torrens E., Ellingsen J.E., Afseth J., Ciardi J.E., Bowen W.H. Effect of topical application of stannous fluoride, stannous chloride and stannous tartrate on rat caries. Scand. J. Dent. Res. 91:1983;351-355.
27. Rudney J.D., Krig M.A., Neuvar E.K., Soberay A.H., Iverson L. Antimicrobial proteins in human unstimulated whole saliva in relation to each other and to measures of health status, dental plaque accumulation and composition. Archs. Oral Biol. 36:1991;497-506.
28. Soukka T., Lumikari M., Tenovuo J. Combined inhibitory effect of lactoferrin and lactoperoxidase system on the viability of Streptococcus mutans serotype c. Scand. J. Dent. Res. 99:1991;390-396.
29. Soukka T., Tenovuo J., Rundegren J. Agglutination of Streptococcus mutans serotype c cells but inhibition of Porphyromonas gingivalis autoaggregation by human lactoferrin. Archs. Oral Biol. 38:1993;227-232.
30. Sveinsson S.J., Mezei M. In vitro oral mucosal absorption of liposomal triamcinolone acetonide. Pharm. Res. 9:1992;1359-1361.
31. Tenovuo J., Grahn E., Lehtonen O.P., Hyyppa T., Karhuvaara L., Vilja P. Antimicrobial factors in saliva ontogeny and relation to oral health. J. Dent. Res. 66:1987;475-479.
32. Tenovuo J.O., Knuuttila M.L.E. Antibacterial effect of salivary peroxidases on a cariogenic strain of Streptococcus mutans. J. Dent. Res. 56:1977;1608-1613.
33. Uemura M., Park K.K., Stookey G.K., Konishi K. Effects of molybdenum on human enamel fluoride uptake and experimental rat dental caries. Archs. Oral Biol. 34:1989;665-668.