Lung-function tests in neonates and infants with chronic lung disease: Tidal breathing and respiratory control

Pediatric Pulmonology

Volumn 41, Issue 5, 2006, Pages 391-419

  Baldwin, David N ^a,b,e   Pillow, J Jane ^a,c   Stocks, Janet ^d   Frey, Urs ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e KING EDWARD MEMORIAL HOSPITAL   (Australia)

Author keywords

Chronic lung disease; Control of breathing; Equipment; Infant; Lung function; Methodology; Tidal breathing

Indexed keywords

ACUTE RESPIRATORY TRACT DISEASE; APNEA; BREATHING PATTERN; CHEMORECEPTOR; CHRONIC LUNG DISEASE; CLINICAL OBSERVATION; FETUS LUNG MATURATION; HUMAN; INCIDENCE; INFANT; LUNG FUNCTION TEST; LUNG MECHANICS; MEASUREMENT; NEWBORN; PREMATURITY; PRIORITY JOURNAL; RESPIRATION CONTROL; REVIEW; RISK; SENSITIVITY ANALYSIS; STRETCH RECEPTOR; SUDDEN INFANT DEATH SYNDROME; SYSTEMATIC REVIEW; TIDAL VOLUME; WAVEFORM;

ADULT; ANIMALS; ANOXIA; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHEMORECEPTORS; CHRONIC DISEASE; FEEDBACK, BIOCHEMICAL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LUNG DISEASES; LUNG VOLUME MEASUREMENTS; MATERNAL EXPOSURE; POSTURE; QUALITY CONTROL; RESPIRATION; RESPIRATORY FUNCTION TESTS; SLEEP; TIDAL VOLUME;

EID: 33646339115     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.20400     Document Type: Review

References (225)

1. Carpenter RG, Irgens LM, Blair PS, England PD, Fleming P, Huber J, Jorch G, Schreuder P. Sudden unexplained infant death in 20 regions in Europe: case control study. Lancet 2004;363:185-191.
2. Alm B, Norvenius SG, Wennergren G, Skjaerven R, Oyen N, Milerad I, Wennborg M, Kjaerbeck J, Helweg-Larsen K, Irgens LM. Changes in the epidemiology of sudden infant death syndrome in Sweden, 1973-1996. Arch Dis Child 2001;84:24-30.
3. Leach CE, Blair PS, Fleming PJ, Smith IJ, Platt MW, Berry PJ, Golding J. Epidemiology of SIDS and explained sudden infant deaths. CESDI SUDI Research Group. Pediatrics 1999;104:43.
4. Carlsen KH, Lodrup Carlsen KC. Tidal breathing analysis and response to salbutamol in awake young children with and without asthma. Eur Respir J 1994;7:2154-2159.
5. Banovcin P, Seidenberg J, Von der Hardt. Assessment of tidal breathing patterns for monitoring of bronchial obstruction in infants. Pediatr Res 1995;38:218-220.
6. Greenough A, Zhang YX, Yuksel B, Dimitriou G. Assessment of prematurely born children at follow-up using a tidal breathing parameter. Physiol Meas 1998;19:111-116.
7. Gaultier C, Gallego J. Development of respiratory control: evolving concepts and perspectives. Respir Physiol Neurobiol. Nov 15: 149(1-3):3-15.
8. Gozal D. New concepts in abnormalities of respiratory control in children. Curr Opin Pediatr 2004;16:305-308.
9. Horne RS, Parslow PM, Harding R. Respiratory control and arousal in sleeping infants. Paediatr Respir Rev 2004;5:190-198.
10. Martin RJ, Abu-Shaweesh JM. Control of breathing and neonatal apnea. Biol Neonate 2005;87:288-295.
11. Richter DW, Ballantyne D. A three phase theory about the basic respiratory pattern generator. In: Schlafke ME, Koepchen HP, editors. Central neurone environment. Berlin: Springer-Verlag; 1983. p 165-174.
12. Feldman JL, Smith JC. Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann NY Acad Sci 1989;563:114-130.
13. Onimaru H, Arata A, Homma I. Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp Brain Res 1989;76:530-536.
14. Duffin J. Functional organisation of respiratory neurons: a brief review of current questions and speculations. Exp Physiol. 2004. Sep 89(5):517-529.
15. Miller AJ, McKoon M, Pinneau M, Silverstein R. Postnatal synaptic development of the rat. Brain Res 1983;284:205-213.
16. Horne RS, Andrew S, Mitchell K, Sly DJ, Cranage SM, Chau B, Adamson TM. Apnoea of prematurity and arousal from sleep. Early Hum Dev 2001;61:119-133.
17. Fewell JE, Taylor BJ, Kondo CS, Dascalu V, Filyk SC. Influence of carotid denervation on the arousal and cardiopulmonary responses to upper airway obstruction in lambs. Pediatr Res 1990;28:374-378.
18. Parslow PM, Harding R, Cranage SM, Adamson TM, Horne RS. Ventilatory responses preceding hypoxia-induced arousal in infants: effects of sleep-state. Respir Physiol Neurobiol 2003;136:235-247.
19. Hertzberg T, Hellstrom S, Lagercrantz H, Pequignot JM. Development of the arterial chemoreflex and turnover of carotid body catecholamines in the newborn rat. J Physiol London 1990;425:211-225.
20. Horne RS, Parslow PM, Harding R. Postnatal development of ventilatory and arousal responses to hypoxia in human infants. Respir Physiol Neurobiol. Nov 15: 149(1-3):257-271.
21. De Boeck C, Van Reempts P, Rigatto H, Chernick V. Naloxone reduces decrease in ventilation induced by hypoxia in newborn infants. J Appl Physiol 1984;56:1507-1511.
22. Rehan V, Haider AZ, Alvaro RE, Nowaczyk B, Cates DB, Kwiatkowski K, Rigatto H. The biphasic ventilatory response to hypoxia in preterm infants is not due to a decrease in metabolism. Pediatr Pulmonol 1996;22:287-294.
23. Thomas DA, Swaminathan S, Beardsmore CS, McArdle EK, MacFadyen UM, Goodenough PC, Carpenter R, Simpson H. Comparison of peripheral chemoreceptor responses in monozygotic and dizygotic twin infants. Am Rev Respir Dis 1993;148:1605-1609.
24. Parks YA, Beardsmore CS, MacFadyen UM, Pallot DJ, Goodenough PC, Carpenter R, Simpson H. The effect of a single breath of 100% oxygen on breathing in infants at 1, 2, and 3 months of age. Am Rev Respir Dis 1991;144:141-145.
25. 2 on ventilation and diaphragmatic electromyography in newborn infants. Respir Physiol 1985;62:387-397.
26. Katz-Salamon M. Delayed chemoreceptor responses in infants with apnoea. Arch Dis Child 2004;89:261-266.
27. Kinney HC, Filiano JJ, White WF. Medullary serotonergic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single dataset. J Neuropathol Exp Neurol 2001;60:228-247.
28. Praud JP, Reix P. Upper airways and neonatal respiration. Respir Physiol Neurobiol 2005:149:131-141.
29. Thach BT. Maturation and transformation of reflexes that protect the laryngeal airway from liquid aspiration from fetal to adult life. Am J Med [Suppl] 2001;111:69-77.
30. Coates EL. Olfactory CO(2) chemoreceptors. Respir Physiol 2001;129:219-229.
31. Rabbette PS, Fletcher ME, Dezateux CA, Soriano-Brucher H, Stocks J. Hering-Breuer reflex and respiratory system compliance in the first year of life: a longitudinal study. J Appl Physiol 1994;76:650-656.
32. Stocks J, Dezateux C, Hoo AF, Rabbette PS, Costeloe K, Wade A. Delayed maturation of Hering-Breuer inflation reflex activity in preterm infants. Am J Respir Crit Care Med 1996;154:1411-1417.
33. Hannam S, Ingram DM, Rabe-Hesketh S, Milner AD. Characterisation of the Hering-Breuer deflation reflex in the human neonate. Respir Physiol 2001;124:51-64.
34. Hannam S, Ingram DM, Milner AD. A possible role for the Hering-Breuer deflation reflex in apnea of prematurity. J Pediatr 1998;132:35-39.
35. Hand IL, Noble L, Wilks M, Towler E, Kim M, Yoon JJ. Hering-Breuer reflex and sleep state in the preterm infant. Pediatr Pulmonol 2004;37:61-64.
36. Kosch PC, Stark AR. Dynamic maintenance of end-expiratory lung volume in full-term infants. J Appl Physiol 1984;57:1126-1133.
37. Kosch PC, Hutchinson AA, Wozniak JA, Carlo WA, Stark AR. Posterior cricoarytenoid and diaphragm activities during tidal breathing in neonates. J Appl Physiol 1988;64:1968-1978.
38. Eichenwald EC, Ungarelli RA, Stark AR. Hypercapnia increases expiratory braking in preterm infants. J Appl Physiol 1993;75:2665-2670.
39. Song G, Poon CS. Functional and structural models of pontine modulation of mechanoreceptor and chemoreceptor reflexes. Respir Physiol Neurobiol 2004;143:281-292.
40. Sachis PN, Armstrong DL, Becker LE, Bryan AC. The vagus nerve and sudden infant death syndrome: a morphometric study. J Pediatr 1981;98:278-280.
41. Botros SM, Bruce EN. Neural network implementation of a three-phase model of respiratory rhythm generation. Biol Cybern 1990;63:143-153.
42. Becker LE, Zhang W. Vagal nerve complex in normal development and sudden infant death syndrome. Can J Neurol Sci 1996;23:24-33.
43. Guntheroth WG, Spiers PS. The triple risk hypotheses in sudden infant death syndrome. Pediatrics 2002;110:64.
44. Ling L, Olson EB Jr, Vidruk EH, Mitchell GS. Phrenic responses to isocapnic hypoxia in adult rats following perinatal hyperoxia. Respir Physiol 1997;109:107-116.
45. Ling L, Olson EB Jr, Vidruk EH, Mitchell GS. Slow recovery of impaired phrenic responses to hypoxia following perinatal hyperoxia in rats. J Physiol London 1998;511:599-603.
46. Katz-Salamon M, Lagercrantz H. Hypoxic ventilatory defence in very preterm infants: attenuation after long term oxygen treatment. Arch Dis Child Fetal Neonatal Ed 1994;70:90-95.
47. Papastamelos C, Panitch HB, England SE, Allen JL. Developmental changes in chest wall compliance in infancy and early childhood. J Appl Physiol 1995;78:179-184.
48. Fletcher ME, Baraldi E, Steinbrugger B. Passive respiratory mechanics. In: Stocks J, Sly PD, Tepper RS, Morgan WJ, editors. Infant respiratory function testing. New York: Wiley-Liss; 1996. p 283-328.
49. England SJ, Stogryn HA. Influence of the upper airway on breathing pattern and expiratory time constant in unanesthetized dog pups. Respir Physiol 1986;66:181-192.
50. England SJ, Harding R, Stradling JR, Phillipson EA. Laryngeal muscle activities during progressive hypercapnia and hypoxia in awake and sleeping dogs. Respir Physiol 1986;66:327-339.
51. England SJ, Ho V, Zamel N. Laryngeal constriction in normal humans during experimentally induced bronchoconstriction. J Appl Physiol 1985;58:352-356.
52. England SJ, Bartlett D Jr. Changes in respiratory movements of the human vocal cords during hyperpnea. J Appl Physiol 1982;52:780-785.
53. England SJ, Bartlett D Jr, Knuth SL. Comparison of human vocal cord movements during isocapnic hypoxia and hypercapnia. J Appl Physiol 1982;53:81-86.
54. Bates JH, Schmalisch G, Filbrun D, Stocks J. Tidal breath analysis for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J 2000;16:1180-1192.
55. Gerhardt T, Hehre D, Feller R, Reifenberg L, Bancalari E. Serial determination of pulmonary function in infants with chronic lung disease. J Pediatr 1987;110:448-456.
56. Gerhardt T, Bancalari E. Apnea of prematurity: II. Respiratory reflexes. Pediatrics 1984;74:63-66.
57. Durand M, Rigatto H. Tidal volume and respiratory frequency in infants with bronchopulmonary dysplasia (BPD). Early Hum Dev 1981;5:55-62.
58. Weintraub Z, Cates D, Kwiatkowski K, Al Hathlol K, Hussain A, Rigatto H. The morphology of periodic breathing in infants and adults. Respir Physiol 2001;127:173-184.
59. Emralino F, Steele AM. Effects of technique and analytic conditions on tidal breathing flow volume loops in term neonates. Pediatr Pulmonol 1997;24:86-92.
60. Ranganathan SC, Goetz I, Hoo AF, Lum S, Castle R, Stocks J. Assessment of tidal breathing parameters in infants with cystic fibrosis. Eur Respir J 2003;22:761-766.
61. Lødrup Carlsen KC, Magnus P, Carlsen KH. Lung function by tidal breathing in awake healthy newborn infants. Eur Respir J 1994;7:1660-1668.
62. Fisher JT, Mortola JP, Smith JB, Fox GS, Weeks S. Respiration in newborns: development of the control of breathing. Am Rev Respir Dis 1982;125:650-657.
63. Paetow U, Windstetter D, Schmalisch G. Variability of tidal breathing flow-volume loops in healthy and sick newborns. Am J Perinatol 1999;16:549-559.
64. Frey U, Stocks J, Coates A, Sly P, Bates J. Specifications for equipment used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J 2000;16:731-740.
65. 2 on "inspiratory drive" and "effective" timing in preterm infants. Early Hum Dev 1981;5:63-70.
66. Frantz ID III, Adler SM, Thach BT, Taeusch HW Jr. Maturational effects on respiratory responses to carbon dioxide in premature infants. J Appl Physiol 1976;41:41-45.
67. Schmalisch G, Foitzik B, Wauer RR, Stocks J. Effect of apparatus dead space on breathing parameters in newborns: "flow-through" versus conventional techniques. Eur Respir J 2001;17:108-114.
68. Konno K, Mead J. Measurement of the separate volume changes of rib cage and abdomen during breathing. J Appl Physiol 1967;22:407-422.
69. Martinot-Lagarde P, Sartene R, Mathieu M, Durand G. What does inductance plethysmography really measure? J Appl Physiol 1988;64:1749-1756.
70. Vegfors M, Lindberg LG, Pettersson H, Oberg PA. Presentation and evaluation of a new optical sensor for respiratory rate monitoring. Int J Clin Monit Comput 1994;11:151-156.
71. Lindberg LG, Ugnell H, Oberg PA. Monitoring of respiratory and heart rates using a fibre-optic sensor. Med Biol Eng Comput 1992;30:533-537.
72. Kondo T, Uhlig T, Pemberton P, Sly PD. Laser monitoring of chest wall displacement. Eur Respir J 1997;10:1865-1869.
73. Pillow JJ, Frerichs I, Stocks J. Lung function testing in acute neonatal respiratory disorders and chronic lung disease of infancy: regional and global ventilation inhomogeneity. Pediatr Pulmonol 2006;41(2):105-121.
74. Frerichs I, Braun P, Dudykevych T, Hahn G, Genee D, Hellige G. Distribution of ventilation in young and elderly adults determined by electrical impedance tomography. Respir Physiol Neurobiol 2004;143:63-75.
75. Hampshire AR, Smallwood RH, Brown BH, Primhak RA. Multifrequency and parametric EIT images of neonatal lungs. Physiol Meas [Suppl] 1995;16:175-189.
76. Schmalisch G, Wauer RR, Foitzik B, Patzak A. Influence of preterm onset of inspiration on tidal breathing parameters in infants with and without CLD. Respir Physiol Neurobiol 2003;135:39-46.
77. Mortola JP, Fisher JT, Smith B, Fox G, Weeks S. Dynamics of breathing in infants. J Appl Physiol 1982;52:1209-1215.
78. Stick S. Measurements during tidal breathing. In: Stocks J, Sly PD, Tepper R, Morgan WJ, editors. Infant respiratory function testing. New York: Wiley-Liss; 1996. p 117-138.
79. Patzak A, Schluter B, Mrowka R, Unbehaun A, Gerhardt D, Persson PB, Barschdorff D, Trowitzsch E. Rhythms and complexity of respiration during sleep in pre-term infants. Clin Physiol 1999;19:458-466.
80. Frey U, Silverman M, Suki B. Analysis of the harmonic content of the tidal flow waveforms in infants. J Appl Physiol 2001;91:1687-1693.
81. Habib RH, Pyon KH, Courtney SE, Aghai ZH. Spectral characteristics of airway opening and chest wall tidal flows in spontaneously breathing preterm infants. J Appl Physiol 2003;94:1933-1940.
82. 2 concentrations in healthy infants. J Appl Physiol 2002;92:1817-1827.
83. Small M, Judd K. Correlation dimension: a pivotal statistic for non-constrained realizations of composite hypotheses in surrogate data analysis. Physica D Nonlin Phenom 1998;120:386-400.
84. Baldwin DN, Suki B, Pillow JJ, Roiha HL, Minocchieri S, Frey U. Effect of sighs on breathing memory and dynamics in healthy infants. J Appl Physiol 2004;97:1830-1839.
85. Frey U, Silverman M, Barabasi AL, Suki B. Irregularities and power law distributions in the breathing pattern in preterm and term infants. J Appl Physiol 1998;85:789-797.
86. Suki B, Frey U. Temporal dynamics of recurrent airway symptoms and cellular random walk. J Appl Physiol 2003;95:2122-2127.
87. Ueda Y, Stick SM, Hall GL, Sly PD. Control of breathing in infants born to smoking mothers. J Pediatr 1999;135:226-232.
88. Reiterer F, Muller W. Assessment of the single-occlusion technique for measurements of respiratory mechanics and respiratory drive in healthy term neonates using a commercially available computerized pulmonary function testing system. Biol Neonate 2003;83:117-122.
89. Brown K, Stocks J, Aun C, Rabbette PS. The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique. J Appl Physiol 1998;84:1437-1446.
90. Neumeister W, Rasche K, Schultze-Werninghaus G. Reproducibility of inspiratory mouth occlusion pressure with a mobile computer-assisted measuring system [in German]. Med Klin [Suppl] 1997;92:18-21.
91. Garg M, Kurzner SI, Bautista D, Keens TG. Hypoxic arousal responses in infants with bronchopulmonary dysplasia. Pediatrics 1988;82:59-63.
92. Katz-Salamon M, Jonsson B, Lagercrantz H. Blunted peripheral chemoreceptor response to hyperoxia in a group of infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1995;20:101-106.
93. Chardon K, Telliez F, Bach V, Leke A, Delanaud S, Bouferrache B, Libert JP, Gaultier C. Effects of warm and cool thermal conditions on ventilatory responses to hyperoxic test in neonates. Respir Physiol Neurobiol 2004;140:145-153.
94. Noble LM, Carlo WA, Miller MJ, DiFiore JM, Martin RJ. Transient changes in expiratory time during hypercapnia in premature infants. J Appl Physiol 1987;62:1010-1013.
95. Bouferrache B, Filtchev S, Leke A, Freville M, Gallego J, Gaultier C. Comparison of the hyperoxic test and the alternate breath test in infants. Am J Respir Crit Care Med 2002;165:206-210.
96. Calder NA, Williams BA, Smyth J, Boon AW, Kumar P, Hanson MA. Absence of ventilatory responses to alternating breaths of mild hypoxia and air in infants who have had bronchopulmonary dysplasia: implications for the risk of sudden infant death. Pediatr Res 1994;35:677-681.
97. Bouferrache B, Filtchev S, Leke A, Marbaix-Li Q, Freville M, Gaultier C. The hyperoxic test in infants reinvestigated. Am J Respir Crit Care Med 2000;161:160-165.
98. Downs JA, Stocks J. Effect of neck rotation on the timing and pattern of infant tidal breathing. Pediatr Pulmonol 1995;20:380-386.
99. Fleming PJ, Levine MR, Goncalves A. Changes in respiratory pattern resulting from the use of a facemask to record respiration in newborn infants. Pediatr Res 1982;16:1031-1034.
100. Dolfin T, Duffty P, Wilkes D, England S, Bryan H. Effects of a face mask and pneumotachograph on breathing in sleeping infants. Am Rev Respir Dis 1983;128:977-979.
101. England SJ. Current techniques for assessing pulmonary function in the newborn and infant: advantages and limitations. Pediatr Pulmonol 1988;4:48-53.
102. Brooks LJ, DiFiore JM, Martin RJ. Assessment of tidal volume over time in preterm infants using respiratory inductance plethysmography, the CHIME Study Group. Collaborative Home Infant Monitoring Evaluation. Pediatr Pulmonol 1997;23:429-433.
103. Frerichs I, Dargaville PA, Dudykevych T, Rimensberger PC. Electrical impedance tomography: a method for monitoring regional lung aeration and tidal volume distribution? Intensive Care Med 2003;29:2312-2316.
104. Whitelaw WA, Derenne JP. Airway occlusion pressure. J Appl Physiol 1993;74:1475-1483.
105. Brown K, Aun C, Jackson E, Mackersie A, Hatch D, Stocks J. Validation of respiratory inductive plethysmography using the qualitative diagnostic calibration method in anaesthetized infants. Eur Respir J 1998;12:935-943.
106. Selbie RD, Fletcher M, Arestis N, White R, Duncan A, Helms P, Duffty P. Respiratory function parameters in infants using inductive plethysmography. Med Eng Phys 1997;19:501-511.
107. Leino K, Nunes S, Valta P, Takala J. Validation of a new respiratory inductive plethysmograph. Acta Anaesthesiol Scand 2001;45:104-111.
108. Bar-Yishay E, Putilov A, Einav S. Automated, real-time calibration of the respiratory inductance plethysmograph and its application in newborn infants. Physiol Meas 2003;24:149-163.
109. Stick SM, Ellis E, LeSouef PN, Sly PD. Validation of respiratory inductance plethysmography ("Respitrace") for the measurement of tidal breathing parameters in newborns. Pediatr Pulmonol 1992;14:187-191.
110. Schibler A, Hall GL, Businger F, Reinmann B, Wildhaber JH, Cernelc M, Frey U. Measurement of lung volume and ventilation distribution with an ultrasonic flow meter in healthy infants. Eur Respir J 2002;20:912-918.
111. Hall GL, Reinmann B, Wildhaber JH, Frey U. Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure. J Appl Physiol 2002;92:59-66.
112. Frey U, Kuehni C, Roiha H, Cernelc M, Reinmann B, Wildhaber JH, Hall GL. Maternal atopic disease modifies effects of prenatal risk factors on exhaled nitric oxide in infants. Am J Respir Crit Care Med 2004;170:260-265.
113. Pillow JJ, Ljungberg H, Hulskamp G, Stocks J. Functional residual capacity measurements in healthy infants: ultrasonic flow meter versus a mass spectrometer. Eur Respir J 2004;23:763-768.
114. E? Am J Respir Crit Care Med 1994;150:1347-1354.
115. Hall GL, Wildhaber JH, Cernelc M, Frey U. Evaluation of the interrupter technique in healthy, unsedated infants. Eur Respir J 2001;18:982-988.
116. Hassan A, Gossage J, Ingram D, Lee S, Milner AD. Volume of activation of the Hering-Breuer inflation reflex in the newborn infant. J Appl Physiol 2001;90:763-769.
117. Cohen G, Malcolm G, Henderson-Smart D. Ventilatory response of the newborn infant to mild hypoxia. Pediatr Pulmonol 1997;24:163-172.
118. 2 in infants. Pediatr Res 1998;44:239-246.
119. North AF Jr, MacDonald HM. Why are neonatal mortality rates lower in small black infants than in white infants in similar birth weight? J Pediatr 1977;90:809-810.
120. Collins JW Jr, David RJ. Differential survival rates among low-birth-weight black and white infants in a tertiary care hospital. Epidemiology 1990;1:16-20.
121. Stocks J, Gappa M, Rabbette PS, Hoo AF, Mukhtar Z, Costeloe KL. A comparison of respiratory function in Afro-Caribbean and Caucasian infants. Eur Respir J 1994;7:11-16.
122. Stocks J, Henschen M, Hoo AF, Costeloe K, Dezateux C. Influence of ethnicity and gender on airway function in preterm infants. Am J Respir Crit Care Med 1997;156:1855-1862.
123. Stocks J, Godfrey S. Nasal resistance during infancy. Respir Physiol 1978;34:233-246.
124. Gaultier C. Genes and genetics in respiratory control. Paediatr Respir Rev 2004;5:166-172.
125. Gaultier C, Guilleminault C. Genetics, control of breathing, and sleep-disordered breathing: a review. Sleep Med 2001;2:281-295.
126. Hoo AF, Henschen M, Dezateux C, Costeloe K, Stocks J. Respiratory function among preterm infants whose mothers smoked during pregnancy. Am J Respir Crit Care Med 1998;158:700-705.
127. Hanrahan JP, Tager IB, Castile RG, Segal MR, Weiss ST, Speizer FE. Pulmonary function measures in healthy infants. Variability and size correction. Am Rev Respir Dis 1990;141:1127-1135.
128. Garg M, Kurzner SI, Bautista DB, Keens TG. Clinically unsuspected hypoxia during sleep and feeding in infants with bronchopulmonary dysplasia. Pediatrics 1988;81:635-642.
129. Craig CM, Lee DN, Freer YN, Laing IA. Modulations in breathing patterns during intermittent feeding in term infants and preterm infants with bronchopulmonary dysplasia. Dev Med Child Neurol 1999;41:616-624.
130. Singer L, Martin RJ, Hawkins SW, Benson-Szekely LJ, Yamashita TS, Carlo WA. Oxygen desaturation complicates feeding in infants with bronchopulmonary dysplasia after discharge. Pediatrics 1992;90:380-384.
131. Hjalmarson O, Sandberg K. Abnormal lung function in healthy preterm infants. Am J Respir Crit Care Med 2002;165:83-87.
132. Haddad GG, Lai TL, Mellins RB. Determination of ventilatory pattern in REM sleep in normal infants. J Appl Physiol 1982;53:52-56.
133. Haddad GG, Epstein RA, Epstein MA, Leistner HL, Marino PA, Mellins RB. Maturation of ventilation and ventilatory pattern in normal sleeping infants. J Appl Physiol 1979;46:998-1002.
134. Adamson TM, Cranage S, Maloney JE, Wilkinson MH, Wilson FE, Yu VY. The maturation of respiratory patterns in normal full term infants during the first six postnatal months. I: sleep states and respiratory variability. Aust Paediatr J 1981;17:250-256.
135. Finer NN, Abroms IF, Taeusch HW Jr. Ventilation and sleep states in newborn infants. J Pediatr 1976;89:100-108.
136. Haddad GG, Lai TL, Epstein MA, Epstein RA, Yu KF, Leistner HL, Mellins RB. Breath-to-breath variations in rate and depth of ventilation in sleeping infants. Am J Physiol 1982;243:164-169.
137. Rigatto H, Kalapesi Z, Leahy FN, Durand M, MacCallum M, Cates D. Chemical control of respiratory frequency and tidal volume during sleep in preterm infants. Respir Physiol 1980;41:117-125.
138. 2-induced changes in ventilation and ventilatory pattern in normal sleeping infants. J Appl Physiol 1980;48:684-688.
139. Campbell AJ, Bolton DP, Taylor BJ, Sayers RM. Responses to an increasing asphyxia in infants: effects of age and sleep state. Respir Physiol 1998;112:51-58.
140. 2 apneic threshold in newborn infants: possible relevance for periodic breathing and apnea. J Appl Physiol 2005;98:1171-1176.
141. Booth CL, Leonard HL, Thoman EB. Sleep states and behavior patterns in preterm and fullterm infants. Neuropediatrics 1980;11:354-364.
142. Zinman R, Blanchard PW, Vachon F. Oxygen saturation during sleep in patients with bronchopulmonary dysplasia. Biol Neonate 1992;61:69-75.
143. Sekar KC, Duke JC. Sleep apnea and hypoxemia in recently weaned premature infants with and without bronchopulmonary dysplasia. Pediatr Pulmonol 1991;10:112-116.
144. Durand M, McEvoy C, MacDonald K. Spontaneous desaturations in intubated very low birth weight infants with acute and chronic lung disease. Pediatr Pulmonol 1992;13:136-142.
145. McEvoy C, Durand M, Hewlett V. Episodes of spontaneous desaturations in infants with chronic lung disease at two different levels of oxygenation. Pediatr Pulmonol 1993;15:140-144.
146. McNamara F, Harris MA, Sullivan CE. Effects of nasal continuous positive airway pressure on apnoea index and sleep in infants. J Paediatr Child Health 1995;31:88-94.
147. Harris MA, Sullivan CE. Sleep pattern and supplementary oxygen requirements in infants with chronic neonatal lung disease. Lancet 1995;345:831-832.
148. Allen JL, Greenspan JS, Deoras KS, Keklikian E, Wolfson MR, Shaffer TH. Interaction between chest wall motion and lung mechanics in normal infants and infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1991;11:37-43.
149. Rome ES, Miller MJ, Goldthwait DA, Osorio IO, Fanaroff AA, Martin RJ. Effect of sleep state on chest wall movements and gas exchange in infants with resolving bronchopulmonary dysplasia. Pediatr Pulmonol 1987;3:259-263.
150. Thomas DA, Poole K, McArdle EK, Goodenough PC, Thompson J, Beardsmore CS, Simpson H. The effect of sleep deprivation on sleep states, breathing events, peripheral chemoresponsiveness and arousal propensity in healthy 3 month old infants. Eur Respir J 1996;9:932-938.
151. Franco P, Seret N, Van Hees JN, Scaillet S, Vermeulen F, Groswasser J, Kahn A. Decreased arousals among healthy infants after short-term sleep deprivation. Pediatrics 2004;114:192-197.
152. Chardon K, Bach V, Telliez F, Tourneux P, Elabbassi EB, Cardot V, Gaultier C, Libert JP. Peripheral chemoreceptor activity in sleeping neonates exposed to warm environments. Neurophysiol Clin 2003;33:196-202.
153. Adams JA, Zabaleta IA, Sackner MA. Comparison of supine and prone noninvasive measurements of breathing patterns in full-term newborns. Pediatr Pulmonol 1994;18:8-12.
154. Gibson E, Fleming N, Fleming D, Culhane J, Hauck F, Janiero M, Spitzer A. Sudden infant death syndrome rates subsequent to the American Academy of Pediatrics supine sleep position. Med Care 1998;36:938-942.
155. Wigfield RE, Fleming PJ, Berry PJ, Rudd PT, Golding J. Can the fall in Avon's sudden infant death rate be explained by changes in sleeping position? Br Med J [Clin Res] 1992;304:282-283.
156. Blair P, Ward Platt MP, Smith IJ, Fleming PJ. Sudden infant death syndrome and sleeping position in pre-term and low birthweight infants: an opportunity for targeted intervention. Arch Dis Child 2006;91(2):101-106.
157. 2. J Perinatol 1991;11:315-318.
158. Bhat RY, Leipala JA, Singh NR, Rafferty GF, Hannam S, Greenough A. Effect of posture on oxygenation, lung volume, and respiratory mechanics in premature infants studied before discharge. Pediatrics 2003;112:29-32.
159. Martin RJ, DiFiore JM, Korenke CB, Randal H, Miller MJ, Brooks LJ. Vulnerability of respiratory control in healthy preterm infants placed supine. J Pediatr 1995;127:609-614.
160. McEvoy C, Mendoza ME, Bowling S, Hewlett V, Sardesai S, Durand M. Prone positioning decreases episodes of hypoxemia in extremely low birth weight infants (1000 grams or less) with chronic lung disease. J Pediatr 1997;130:305-309.
161. Wolfson MR, Greenspan JS, Deoras KS, Allen JL, Shaffer TH. Effect of position on the mechanical interaction between the rib cage and abdomen in preterm infants. J Appl Physiol 1992;72:1032-1038.
162. Heimler R, Langlois J, Hodel DJ, Nelin LD, Sasidharan P. Effect of positioning on the breathing pattern of preterm infants. Arch Dis Child 1992;67:312-314.
163. Kurlak LO, Ruggins NR, Stephenson TJ. Effect of nursing position on incidence, type, and duration of clinically significant apnoea in preterm infants. Arch Dis Child Fetal Neonatal Ed 1994;71:16-19.
164. Leipala JA, Bhat RY, Rafferty GF, Hannam S, Greenough A. Effect of posture on respiratory function and drive in preterm infants prior to discharge. Pediatr Pulmonol 2003;36:295-300.
165. Hutchison AA, Ross KR, Russell G. The effect of posture on ventilation and lung mechanics in preterm and light-for-date infants. Pediatrics 1979;64:429-432.
166. Martin RJ, Herrell N, Rubin D, Fanaroff A. Effect of supine and prone positions on arterial oxygen tension in the preterm infant. Pediatrics 1979;63:528-531.
167. Fox RE, Viscardi RM, Taciak VL, Niknafs H, Cinoman MI. Effect of position on pulmonary mechanics in healthy preterm newborn infants. J Perinatol 1993;13:205-211.
168. Bu'Lock F, Woolridge MW, Baum JD. Development of coordination of sucking, swallowing and breathing: ultrasound study of term and preterm infants. Dev Med Child Neurol 1990;32:669-678.
169. Timms BJ, DiFiore JM, Martin RJ, Miller MJ. Increased respiratory drive as an inhibitor of oral feeding of preterm infants. J Pediatr 1993;123:127-131.
170. Hershenson M, Brouillette RT, Olsen E, Hunt CE. The effect of chloral hydrate on genioglossus and diaphragmatic activity. Pediatr Res 1984;18:516-519.
171. Tepper RS, Morgan WJ, Cota K, Wright A, Taussig LM. Physiologic growth and development of the lung during the first year of life. Am Rev Respir Dis 1986;134:513-519.
172. Hunt CE, Hazinski TA, Gora P. Experimental effects of chloral hydrate in ventilatory response to hypoxia and hypercarbia. Pediatr Res 1982;16:79-81.
173. Lees MH, Olsen GD, McGilliard KL, Newcomb JD, Sunderland CO. Chloral hydrate and the carbon dioxide chemoreceptor response: a study of puppies and infants. Pediatrics 1982;70:447-450.
174. Jackson EA, Rabbette PS, Dezateux C, Hatch DJ, Stocks J. The effect of triclofos sodium sedation on respiratory rate, oxygen saturation, and heart rate in infants and young children. Pediatr Pulmonol 1991;10:40-45.
175. Rabbette PS, Dezateux CA, Fletcher ME, Costeloe KL, Stocks J. Influence of sedation on the Hering-Breuer inflation reflex in healthy infants. Pediatr Pulmonol 1991;11:217-222.
176. Reimche LD, Sankaran K, Hindmarsh KW, Kasian GF, Gorecki DK, Tan L. Chloral hydrate sedation in neonates and infants-clinical and pharmacologic considerations. Dev Pharmacol Ther 1989;12:57-64.
177. Allen J, Zwerdling R, Ehrenkranz R, Gaultier C, Geggel R, Greenough A, Kleinman R, Klijanowicz A, Martinez F, Ozdemir A, Panitch HB, Nickerson B, Stein MT, Tomezsko J, Van der Anker J. Statement on the care of the child with chronic lung disease of infancy and childhood. Am J Respir Crit Care Med 2003;168:356-396.
178. Bancalari E, Claure N, Sosenko IR. Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definition. Semin Neonatol 2003;8:63-71.
179. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-1729.
180. Tepper RS, Morgan WJ, Cota K, Taussig LM. Expiratory flow limitation in infants with bronchopulmonary dysplasia. J Pediatr 1986;109:1040-1046.
181. Kilbride HW, Gelatt MC, Sabath RJ. Pulmonary function and exercise capacity for ELBW survivors in preadolescence: effect of neonatal chronic lung disease. J Pediatr 2003;143:488-493.
182. Kinali M, Greenough A, Dimitriou G, Yuksel B, Hooper R. Chronic respiratory morbidity following premature delivery-prediction by prolonged respiratory support requirement? Eur J Pediatr 1999;158:493-496.
183. Gappa M, Stocks J, Merkus P. Lung growth and development after preterm birth: further evidence. Am J Respir Crit Care Med 2003;168:399.
184. Le Souef PN, Hughes DM, Landau LI. Shape of forced expiratory flow-volume curves in infants. Am Rev Respir Dis 1988;138:590-597.
185. Makikallio TH, Koistinen J, Jordaens L, Tulppo MP, Wood N, Golosarsky B, Peng CK, Goldberger AL, Huikuri HV. Heart rate dynamics before spontaneous onset of ventricular fibrillation in patients with healed myocardial infarcts. Am J Cardiol 1999;83:880-884.
186. Ho KK, Moody GB, Peng CK, Mietus JE, Larson MG, Levy D, Goldberger AL. Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics. Circulation 1997;96:842-848.
187. Peng CK, Mietus JE, Liu Y, Lee C, Hausdorff JM, Stanley HE, Goldberger AL, Lipsitz LA. Quantifying fractal dynamics of human respiration: age and gender effects. Ann Biomed Eng 2002;30:683-692.
188. Sapir N, Karasik R, Havlin S, Simon E, Hausdorff JM. Detecting scaling in the period dynamics of multimodal signals: application to Parkinsonian tremor. Phys Rev E Stat Nonlin Soft Matter Phys 2003;67:1-8.
189. Clarke JR, Aston H, Silverman M. Evaluation of a tidal expiratory flow index in healthy and diseased infants. Pediatr Pulmonol 1994;17:285-290.
190. Alvaro RE, de Almeida V, Kwiatkowski K, Cates D, Kryger M, Rigatto H. A developmental study of the dose-response curve of the respiratory sensory reflex. Am Rev Respir Dis 1993;148:1013-1017.
191. Al Shway SF, Mortola JP. Respiratory effects of airflow through the upper airways in newborn kittens and puppies. J Appl Physiol 1982;53:805-814.
192. Boggs DF, Bartlett D Jr. Chemical specificity of a laryngeal apneic reflex in puppies. J Appl Physiol 1982;53:455-462.
193. Abu-Shaweesh JM. Maturation of respiratory reflex responses in the fetus and neonate. Semin Neonatol 2004;9:169-180.
194. Hadeed A, Siegel S. Newborn cardiac arrhythmias associated with maternal caffeine use during pregnancy. Clin Pediatr (Phila) 1993;32:45-47.
195. Ford RP, Schluter PJ, Mitchell EA, Taylor BJ, Scragg R, Stewart AW. Heavy caffeine intake in pregnancy and sudden infant death syndrome. New Zealand Cot Death Study Group. Arch Dis Child 1998;78:9-13.
196. Herlenius E, Aden U, Tang LQ, Lagercrantz H. Perinatal respiratory control and its modulation by adenosine and caffeine in the rat. Pediatr Res 2002;51:4-12.
197. Laubscher B, Greenough A, Dimitriou G. Comparative effects of theophylline and caffeine on respiratory function of prematurely born infants. Early Hum Dev 1998;50:185-192.
198. Chardon K, Bach V, Telliez F, Cardot V, Tourneux P, Leke A, Libert JP. Effect of caffeine on peripheral chemoreceptor activity in premature neonates: interaction with sleep stages. J Appl Physiol 2004;96:2161-2166.
199. von Poblotzki M, Rieger-Fackeldey E, Schulze A. Effects of theophylline on the pattern of spontaneous breathing in preterm infants less than 1000 g of birth weight. Early Hum Dev 2003;72:47-55.
200. Davis JM, Bhutani VK, Stefano JL, Fox WW, Spitzer AR. Changes in pulmonary mechanics following caffeine administration in infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1989;6:49-52.
201. Aranda JV, Turmen T, Davis J, Trippenbach T, Grondin D, Zinman R, Watters G. Effect of caffeine on control of breathing in infantile apnea. J Pediatr 1983;103:975-978.
202. Glotzbach SF, Tansey PA, Baldwin RB, Ariagno RL. Periodic breathing in preterm infants: influence of bronchopulmonary dysplasia and theophylline. Pediatr Pulmonol 1989;7:78-81.
203. Gaultier C, Amiel J, Dauger S, Trang H, Lyonnet S, Gallego J, Simonneau M. Genetics and early disturbances of breathing control. Pediatr Res 2004;55:729-733.
204. Stocks J, Dezateux C. The effect of parental smoking on lung function and development during infancy. Respirology 2003;8:266-285.
205. Pierce RA, Nguyen NM. Prenatal nicotine exposure and abnormal lung function. Am J Respir Cell Mol Biol 2002;26:10-13.
206. Kawakami Y, Yamamoto H, Yoshikawa T, Shida A. Chemical and behavioral control of breathing in adult twins. Am Rev Respir Dis 1984;129:703-707.
207. Shea SA, Benchetrit G, Pham Dinh T, Hamilton RD, Guz A. The breathing patterns of identical twins. Respir Physiol 1989;75:211-223.
208. Sovik S, Lossius K, Eriksen M, Grogaard J, Walloe L. Development of oxygen sensitivity in infants of smoking and non-smoking mothers. Early Hum Dev 1999;56:217-232.
209. Parslow PM, Cranage SM, Adamson TM, Harding R, Horne RS. Arousal and ventilatory responses to hypoxia in sleeping infants: effects of maternal smoking. Respir Physiol Neurobiol 2004;140:77-87.
210. Hafstrom O, Milerad J, Sundell HW. Prenatal nicotine exposure blunts the cardiorespiratory response to hypoxia in lambs. Am J Respir Crit Care Med 2002;166:1544-1549.
211. Hafstrom O, Milerad J, Sundell HW. Altered breathing pattern after prenatal nicotine exposure in the young lamb. Am J Respir Crit Care Med 2002;166:92-97.
212. Lewis KW, Bosque EM. Deficient hypoxia awakening response in infants of smoking mothers: possible relationship to sudden infant death syndrome. J Pediatr 1995;127:691-699.
213. Sandberg K, Poole SD, Hamdan A, Arbogast P, Sundell HW. Altered lung development after prenatal nicotine exposure in young lambs. Pediatr Res 2004;56:432-439.
214. Bamford OS, Carroll JL. Dynamic ventilatory responses in rats: normal development and effects of prenatal nicotine exposure. Respir Physiol 1999;117:29-40.
215. Luo Z, Costy-Bennett S, Fregosi RF. Prenatal nicotine exposure increases the strength of GABA(A) receptor-mediated inhibition of respiratory rhythm in neonatal rats. J Physiol London 2004;561:387-393.
216. Falk L, Nordberg A, Seiger A, Kjaeldgaard A, Hellstrom-Lindahl E. Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum. Neuroscience 2005;132:389-397.
217. Huang YH, Brown AR, Costy-Bennett S, Luo Z, Fregosi RF. Influence of prenatal nicotine exposure on postnatal development of breathing pattern. Respir Physiol Neurobiol 2004;143:1-8.
218. Slotkin TA, Saleh JL, McCook EC, Seidler FJ. Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome. Teratology 1997;55:177-184.
219. Frey U, Stocks J, Sly P, Bates J. Specification for signal processing and data handling used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. Eur Respir J 2000;16:1016-1022.
220. Warren RH, Horan SM, Robertson PK. Chest wall motion in preterm infants using respiratory inductive plethysmography. Eur Respir J 1997;10:2295-2300.
221. Gerhardt T, Bancalari E. Apnea of prematurity: I. Lung function and regulation of breathing. Pediatrics 1984;74:58-62.
222. Sovik S, Lossius K. Development of ventilatory response to transient hypercapnia and hypercapnic hypoxia in term infants. Pediatr Res 2004;55:302-309.
223. Rabbette PS, Stocks J. Influence of volume dependency and timing of airway occlusions on the Hering-Breuer reflex in infants. J Appl Physiol 1998;85:2033-2039.
224. Mendoza JC, Roberts JL, Cook LN. Postural effects on pulmonary function and heart rate of preterm infants with lung disease. J Pediatr 1991;118:445-448.
225. Durand M, Leahy FN, MacCallum M, Cates DB, Rigatto H, Chernick V. Effect of feeding on the chemical control of breathing in the newborn infant. Pediatr Res 1981;15:1509-1512.