The biphasic ventilatory response to hypoxia in preterm infants is not due to a decrease in metabolism

Pediatric Pulmonology

Volumn 22, Issue 5, 1996, Pages 287-294

  Rehan, Virender ^a   Haider, A Zia ^a   Alvaro, Ruben E ^a   Nowaczyk, Bogdan ^a   Cates, Donald B ^a   Kwiatkowski, Kim ^a   Rigatto, Henrique ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

CO2 inhalation; control of ventilation; hypoxic response; newborn infant; Respiration

Indexed keywords

CARBON DIOXIDE; NEUROTRANSMITTER; OXYGEN;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GAS MIXING; GESTATIONAL AGE; HUMAN; INFANT; LUNG ALVEOLUS CARBON DIOXIDE TENSION; LUNG MINUTE VOLUME; LUNG VENTILATION; METABOLISM; NEUROTRANSMITTER RELEASE; NEWBORN; NEWBORN HYPOXIA; OXYGEN CONSUMPTION; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATION CONTROL; TIDAL VOLUME;

ANOXIA; CARBON DIOXIDE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; OXYGEN CONSUMPTION; RESPIRATION; RESPIRATION, ARTIFICIAL; RESPIRATORY FUNCTION TESTS; SLEEP;

EID: 0029905565     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0496(199611)22:5<287::AID-PPUL1>3.0.CO;2-I     Document Type: Article

References (37)

1. Cross KW, Oppé TE. The effect of inhalation of high and low concentration of oxygen on the respiration of the premature infant. J Physiol (Lond). 1952; 117:38-55.
2. Cross KW, Hopper JMD, Lord JM. Anoxic depression of the medulla in the new-born infant. J Physiol. 1954; 125:628-640.
3. Cross KW, Tizard JPM, Trythall DAH. The gaseous metabolism of the new born infant breathing 15% oxygen. Acta Pediatr. 1958; 47:217-237.
4. Brady JP, Ceruti E. Chemoreceptor reflexes in the newborn infant: Effects of varying degrees of hypoxia on heart rate and ventilation in a warm environment. J Physiol (Lond). 1966; 184:631-645.
5. Rigatto H, Brady JP, de la Toore Verduzco R. Chemoreceptor reflexes in preterm infants. I. The effect of gestational and postnatal age on the ventilatory response to inhalation of 100% and 15% oxygen. Pediatrics. 1975; 55:604-613.
6. Rigatto H. Ventilatory response to hypoxia. Semin Perinatol. 1977; 1:357-362.
7. Rigatto H, Brady JP. Periodic breathing and apnea in preterm infants: II. Hypoxia as a primary event. Pediatrics. 1972; 50: 219-228.
8. Adamson K Jr. Breathing and the thermal environment in young rabbits. J Physiol. 1959; 149:144-153.
9. 2 production and ventilation in the hypoxic kitten. J Appl Physiol. 1993; 74:904-910.
10. Cross KW, Dawes GS, Mott JC. Anoxia, oxygen consumption and cardiac output in newborn lambs and adult sheep. J Physiol. 1959; 146:316-343.
11. Schwieler GH. Respiratory regulation during postnatal development in cats and rabbits and some morphological substrate. Acta Physiol Scand. 1968; 304(Suppl):49-63.
12. 2 on ventilation and diaphragmatic electromyography in newborn infants. Respir Physiol. 1985; 62: 387-397.
13. Rigatto H, Brady JP. A new nosepiece for measuring ventilation in preterm infants. J Appl Physiol. 1972; 32:423-424.
14. Frappell P, Saiki C, Mortola JP. Metabolism during normoxia, hypoxia and recovery in the newborn kitten. Respir Physiol. 1991; 86:115-124.
15. Rigatto H, Brady JP. Periodic breathing and apnea in preterm infants. I. Evidence of hypoventilation possibly due to central respiratory depression. Pediatrics. 1972; 50:202-218.
16. Gershan WM, Forster HV, Lowry TF, Korducki MJ, Forster AL, Forster MA, Ohtake PJ, Aaron EA, Garber AK. Effect of metabolic rate on ventilatory roll-off during hypoxia. J Appl Physiol. 1994; 76:2310-2314.
17. Haddad GG, Gandhi MR, Mellins RB. Maturation of ventilatory response to hypoxia in puppies during sleep. J Appl Physiol. 1982; 52:309-314.
18. Mortola JP, Rezzonico R, Lanthier C. Ventilation and oxygen consumption during acute hypoxia in newborn mammals: A comparative analysis. Respir Physiol. 1989; 78:31-48.
19. Rigatto H, Wiebe C, Rigatto C, Lee DS, Gates DB. Ventilatory response to hypoxia in unanesthetized newborn kittens. J Appl Physiol. 1988; 64:2544-2551.
20. Easton PA, Slykerman LJ, Anthonisen NR. Ventilatory response to sustained hypoxia in normal adults. J Appl Physiol. 1986; 61:906-911.
21. Weil JV, Zwillich CW. Assessment of ventilatory response to hypoxia: Methods and interpretations. Chest. 1976; 70(Suppl): 124-128.
22. LaFramboise WA, Guthrie RD, Standaert TA, Woodrum DE. Pulmonary mechanics during the ventilatory response to hypoxemia in the newborn monkey. J Appl Physiol. 1983; 55:1008-1014.
23. Wetzel RC, Herold CJ, Zerhouni EA, Robotharn JL. Hypoxic bronchodilation. J Appl Physiol. 1992; 73:1202-1206.
24. 2 on the ventilatory response to hypoxia. Pediatrics. 1970: 45:206-215.
25. Lopes JM, Davis GM, Mullahoc K, Aranda JV. The role of adenosine on the hypoxic ventilatory response of the newborn piglets. Pediatr Pulmonol. 1994; 17:50-55.
26. Fraud JP, Canet E, Kianicka I, Gaultier C, Bureau M. Vagal and chemoreceptor influences on abdominal muscle activity in awake lambs during hypoxia. J Appl Physiol. 1993; 74:1689-1696.
27. 2 and the activity recorded from few or multifibre chemoreceptor preparations of the carotid sinus nerve. In: Benchetrit G, Baconnier P, Demongeot J, eds. Concepts and Formalization in the Control of Breathing. Manchester, UK: University Press, 1987:39-43.
28. 2 load. J Appl Physiol. 1987; 50:45-54.
29. 2 plus cord occlusion in the fetal sheep. J Dev Physiol. 1992; 17:227-232.
30. 2 breathing on ventilatory response to sustained hypoxia in normal adults. J Appl Physiol. 1989; 66:1071-1078.
31. Dreshraj IA, Haxhiu MA, Miller MJ, Martin RJ. Endothelia-1 (ET1) acting on central chemosensitive areas causes respiratory depression in piglets. Pediatr Res. 1993; 33:A1923 (abstract).
32. Deboeck C, van Reempts P, Rigatto H, Chernick V. Naloxone reduces decrease in ventilation induced by hypoxia in newborn infants. J Appl Physiol. 1984; 56:1507-1511.
33. Young RSK, During JM, Donnelly DF, Aquila WJ, Perry VL, Haddad GG. Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: In vitro microdialysis. Am J Physiol. 1993; 264:716-719.
34. Lawson EE, Long WA. Central origin of biphasic breathing pattern during hypoxia in newborns. J Appl Physiol. 1983; 55:483-488.
35. Dawes GS, Gardner WN. Johnston BM, Walker DW. Breathing in fetal lambs: The effect of brain stem section. J Physiol (Lond). 1983; 335:535-553.
36. Gluckman PD, Johnston BM. Lesions in the upper lateral pons abolish the hypoxic depression of breathing in unanesthetized fetal lambs in utero. J Physiol (Lond). 1987; 382:373-383.
37. Johnston BM, Gluckman PD. Peripheral chemoreceptors respond to hypoxia in pontine-lesioned fetal lambs in utero. J Appl Physiol. 1993; 75:1027-1034.