Prenatal nicotine exposure blunts the cardiorespiratory response to hypoxia in lambs

American Journal of Respiratory and Critical Care Medicine

Volumn 166, Issue 12 I, 2002, Pages 1544-1549

  Hafström, Ola ^a   Milerad, Joseph ^a   Sundell, Håkan W ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemoreceptors; Prenatal nicotine exposure delayed effects; Respiration; Smoking; Sudden infant death

Indexed keywords

NICOTINE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CARDIOPULMONARY HEMODYNAMICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEFENSE MECHANISM; FEMALE; HYPOXIA; LAMB; LUNG VENTILATION; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; SLEEP; WAKEFULNESS;

ANIMALS; ANOXIA; BLOOD PRESSURE; CHEMORECEPTORS; FEMALE; HEART RATE; NICOTINE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RESPIRATION; SHEEP;

EID: 0037115273     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200204-289OC     Document Type: Article

References (52)

1. Mortola JP, Rezzonico R, Lanthier C. Ventilation and oxygen consumption during acute hypoxia in newborn mammals: A comparative analysis. Respir Physiol 1989;78:31-43.
2. Bureau MA, Zinman R, Foulon P, Begin R. Diphasic ventilatory response to hypoxia in newborn lambs. J Appl Physiol 1984;56:84-90.
3. Sekar KC, Duke JC. Sleep apnea and hypoxemia in recently weaned premature infants with and without bronchopulmonary dysplasia. Pediatr Pulmonol 1991;10:112-116.
4. Waters KA, Forbes P, Morielli A, Hum C, O'Gorman AM, Vernet O, Davis GM, Tewfik TL, Ducharme FM, Brouillette RT. Sleep-disordered breathing in children with myelomeningocele. J Pediatr 1998; 132:672-681.
5. Guilleminault C, Stoohs R. From apnea of infancy to obstructive sleep apnea syndrome in the young child. Chest 1992;102:1065-1071.
6. Katz-Salamon M, Jonsson B, Lagercrantz H. Blunted peripheral chemoreceptor response to hyperoxia in a group of infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1995;20:101-106.
7. Gozal D, Arens R, Omlin KJ, Jacobs RA, Keens TG. Peripheral chemoreceptor function in children with myelomeningocele and Arnold-Chiari malformation type 2. Chest 1995;108:425-431.
8. van der Hal AL, Rodriguez AM, Sargent CW, Platzker AC, Keens TG. Hypoxic and hypercapneic arousal responses and prediction of subsequent apnea in apnea of infancy. Pediatrics 1985;75:848-854.
9. Hunt CE, Brouillette RT. Sudden infant death syndrome: 1987 Perspective. J Pediatr 1987;110:669-678.
10. Slotkin TA, Lappi SE, McCook EC, Lorber BA, Seidler FJ. Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: Implications for sudden infant death syndrome. Brain Res Bull 1995;38:69-75.
11. Hafstrom O, Milerad J, Asokan N, Poole SD, Sundell HW. Nicotine delays arousal during hypoxemia in lambs. Pediatr Res 2000;47:646-652.
12. Lewis KW, Bosque EM. Deficient hypoxia awakening response in infants of smoking mothers: Possible relationship to sudden infant death syndrome. J Pediatr 1995;127:691-699.
13. Fewell JE, Smith FG, Ng VK. Prenatal exposure to nicotine impairs protective responses of rat pups to hypoxia in an age-dependent manner. Respir Physiol 2001;127:61-73.
14. Harding R, Tester ML, Moss TJ, Davey MG, Louey S, Joyce B. Effects of intra-uterine growth restriction on the control of breathing and lung development after birth. Clin Exp Pharmacol Physiol 2000;27:114-119.
15. Hafstrom O, Milerad J, Sundell HW. Altered breathing pattern after prenatal nicotine exposure in the young lamb. Am J Respir Crit Care Med 2002;166:92-97.
16. Hariharan M, VanNoord T, Greden JF. A high-performance liquid-chromatographic method for routine simultaneous determination of nicotine and cotinine in plasma. Clin Chem 1988;34:724-729.
17. Milerad J, Larsson H, Lin J, Sundell HW. Nicotine attenuates the ventilatory response to hypoxia in the developing lamb. Pediatr Res 1995;37: 652-660.
18. Lindgren C, Lin J, Graham BS, Gray ME, Parker RA, Sundell HW. Respiratory syncytial virus infection enhances the response to laryngeal chemostimulation and inhibits arousal from sleep in young lambs. Acta Paediatr 1996;85:789-797.
19. Milerad J, Larsson H, Lin J, Lindstrom DP, Sundell HW. Breath-by-breath determinations of airway occlusion pressure in the developing lamb. Eur J Appl Physiol 1996;74:44-51.
20. Whitelaw WA, Derenne JP. Airway occlusion pressure. J Appl Physiol 1993;74:1475-1483.
21. 2 ventilatoire a la période néonatal chez l'omme. J Physiol (Paris) 1960;52:108-109.
22. St.-John WM, Leiter JC. Maternal nicotine depresses eupneic ventilation of neonatal rats. Neurosci Lett 1999;267:206-208.
23. Bamford OS, Schuen JN, Carroll JL. Effect of nicotine exposure on postnatal ventilatory responses to hypoxia and hypercapnia. Respir Physiol 1996;106:1-11.
24. Bamford OS, Carroll JL. Dynamic ventilatory responses in rats: Normal development and effects of prenatal nicotine exposure. Respir Physiol 1999;117:29-40.
25. Robinson DM, Peebles KC, Kwok H, Adams BM, Clarke LL, Woollard GA, Funk GD. Prenatal nicotine exposure increases apnoea and reduces nicotinic potentiation of hypoglossal inspiratory output in mice. J Physiol (Lond) 2002;538:957-973.
26. Ueda Y, Stick SM, Hall G, Sly PD. Control of breathing in infants born to smoking mothers. J Pediatr 1999;135:226-232.
27. Sovik S, Lossius K, Eriksen M, Grogaard J, Walloe L. Development of oxygen sensitivity in infants of smoking and non-smoking mothers. Early Hum Dev 1999;56:217-232.
28. Campbell AJ, Galland BC, Bolton DP, Taylor BJ, Sayers RM, Williams SM. Ventilatory responses to rebreathing in infants exposed to maternal smoking. Acta Paediatr 2001;90:793-800.
29. Hilton SM. The defence-arousal system and its relevance for circulatory and respiratory control. J Exp Biol 1982;100:159-174.
30. Bowes G, Townsend ER, Kozar LF, Bromley SM, Phillipson EA. Effect of carotid body denervation on arousal response to hypoxia in sleeping dogs. J Appl Physiol 1981;51:40-45.
31. Fewell JE, Kondo CS, Dascalu V, Filyk SC. Influence of carotid denervation on the arousal and cardiopulmonary response to rapidly developing hypoxemia in lambs. Pediatr Res 1989;25:473-477.
32. Marshall JM. Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev 1994;74:543-594.
33. Wyatt CN, Peers C. Nicotinic acetylcholine receptors in isolated type I cells of the neonatal rat carotid body. Neuroscience 1993;54:275-281.
34. Obeso A, Gomez-Nino MA, Almaraz L, Dinger B, Fidone S, Gonzalez C. Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells. Brain Res 1997;754:298-302.
35. Shirahata M, Ishizawa Y, Rudisill M, Schofield B, Fitzgerald RS. Presence of nicotinic acetylcholine receptors in cat carotid body afferent system. Brain Res 1998;814:213-217.
36. Gomez-Nino A, Dinger B, Gonzalez C, Fidone SJ. Differential stimulus coupling to dopamine and norepinephrine stores in rabbit carotid body type I cells. Brain Res 1990;525:160-164.
37. Svensson TH, Engberg G. Effect of nicotine on single cell activity in the noradrenergic nucleus locus coeruleus. Acta Physiol Scand Suppl 1980;479:31-34.
38. Andersson K, Eneroth P, Fuxe K, Mascagni F, Agnati LF. Effects of chronic exposure to cigarette smoke on amine levels and turnover in various hypothalamic catecholamine nerve terminal systems and on the secretion of pituitary hormones in the male rat. Neuroendocrinology 1985;41:462-466.
39. Hertzberg T, Hellstrom S, Lagercrantz H, Pequignot JM. Development of the arterial chemoreflex and turnover of carotid body catecholamines in the newborn rat. J Physiol (Lond) 1990;425:211-225.
40. Llados F, Zapata P. Effects of dopamine analogues and antagonists on carotid body chemosensors in situ. J Physiol (Lond) 1978;274:487-499.
41. Goiny M, Lagercrantz H, Srinivasan M, Ungerstedt U, Yamamoto Y. Hypoxia-mediated in vivo release of dopamine in nucleus tractus solitarii of rabbits. J Appl Physiol 1991;70:2395-2400.
42. Hafstrom O, Poole SD, Milerad J, Sundell HW. Dopaminergic mediation of delayed arousal from quiet sleep in young lambs exposed to nicotine in utero. Pediatr Res 1998;43:332A.
43. Hafstrom O, Poole SD, Milerad J, Sundell HW. The impaired ventilatory response to acute hypoxemia in sleeping lambs exposed to nicotine prenatally is mediated by a dopaminergic mechanism. Pediatr Res 1998;43:332A.
44. Niedermaier ON, Smith ML, Beightol LA, Zukowska-Grojec Z, Goldstein DS, Eckberg DL. Influence of cigarette smoking on human autonomic function. Circulation 1993;88:562-571.
45. Navarro HA, Mills E, Seidler FJ, Baker FE, Lappi SE, Tayyeb MI, Spencer JR, Slotkin TA. Prenatal nicotine exposure impairs beta-adrenergic function: Persistent chronotropic subsensitivity despite recovery from deficits in receptor binding. Brain Res Bull 1990;25:233-237.
46. Phillipson EA, Bower G. Control of breathing during sleep. In: Cherniack NS, Widdicome JG, editors. Handbook of Physiology. The Respiratory System. Control of Breathing, Part 2: American Physiological Society; 1986. p. 649-689.
47. Frank MG, Srere H, Ledezma C, O'Hara B, Heller HC. Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: Implications for SIDS. Am J Physiol Regul Integr Comp Physiol 2001; 280:R1134-R1140.
48. Hayde M, Bernaschek G, Stevenson DK, Knight GJ, Haddow JE, Widness JA. Antepartum fetal and maternal carboxyhemoglobin and cotinine levels among cigarette smokers. Acta Paediatr 1999;88:327-331.
49. Oncken CA, Hardardottir H, Hatsukami DK, Lupo VR, Rodis JF, Smeltzer JS. Effects of transdermal nicotine or smoking on nicotine concentrations and maternal-fetal hemodynamics. Obstet Gynecol 1997; 90:569-574.
50. Navarro HA, Seidler FJ, Schwartz RD, Baker FE, Dobbins SS, Slotkin TA. Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth. Brain Res Bull 1989;23:187-192.
51. 2. J Appl Physiol 1975;38:16-19.
52. Smith TF, Hudgel DW. Decreased ventilation response to hypoxia in children with asthma. J Pediatr 1980;97:736-741.