Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes: Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation

FEBS Journal

Volumn 273, Issue 10, 2006, Pages 2223-2231

  Kim, Keon Hee ^a   Isin, Emre M ^b   Yun, Chul Ho ^a   Kim, Dong Hyun ^c   Guengerich, F ^b  

^a Chonnam National University   (South Korea)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Korea Institute of Science and Technology   (South Korea)

Author keywords

Alkoxycoumarins; Coumarins; Cytochrome P450; Kinetic isotope effects; Microsomal reactions

Indexed keywords

7 ETHOXYCOUMARIN; CARBON; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; DEUTERIUM; HERNIARIN; HYDROGEN; IRON; OXYGEN;

ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CATALYSIS; CATALYST; CHEMICAL BOND; CHEMICAL REACTION; DEALKYLATION; DEETHYLATION; DISSOCIATION; ENZYME KINETICS; HUMAN; HUMAN TISSUE; HYDROXYLATION; KINETIC ISOTOPE EFFECT; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; REACTION TIME;

7-ALKOXYCOUMARIN O-DEALKYLASE; ANIMALS; BINDING, COMPETITIVE; CATALYSIS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; HUMANS; ISOTOPE LABELING; KINETICS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS;

EID: 33646267951     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05235.x     Document Type: Article

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