Genomic organisation of the mouse gene encoding endothelin-converting enzyme-1 (ECE-1) and mRNA expression of ECE-1 isoforms in murine tissues

Gene

Volumn 373, Issue 1-2, 2006, Pages 109-115

  Lindenau, Steffi ^a   von Langsdorff, Christian ^a   Saxena, Amit ^a   Paul, Martin ^a   Orzechowski, Hans Dieter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Exon intron structure; Metalloprotease; Real time PCR; Splice variant

Indexed keywords

ENDOTHELIN CONVERTING ENZYME; GENOMIC DNA; ISOPROTEIN; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; CHROMOSOME; COMPARATIVE GENE MAPPING; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EXON; GENE EXPRESSION; GENE MAPPING; GENE SEQUENCE; GENE STRUCTURE; GENETIC CODE; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; INTRON; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; SEQUENCE ANALYSIS; STRUCTURAL GENOMICS; TISSUE DISTRIBUTION;

ALGORITHMS; AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ENDOPEPTIDASES; CLONING, MOLECULAR; EXONS; GENOMICS; INTRONS; ISOENZYMES; METALLOENDOPEPTIDASES; MICE; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; TISSUE DISTRIBUTION;

ANIMALIA; MAMMALIA; MURINAE;

EID: 33646247853     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2006.01.024     Document Type: Article

References (25)

1. Cailler F., Zappulla J.P., Boileau G., and Crine P. The N-terminal segment of endothelin-converting enzyme (ECE)-1b contains a di-leucine motif that can redirect neprilysin to an intracellular compartment in Madin-Darby canine kidney (MDCK) cells. Biochem. J. 341 (1999) 119-126
2. Eckman E.A., Watson M., Marlow L., Sambamurti K., and Eckman C.B. Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J. Biol. Chem. 278 (2003) 2081-2084
3. Emoto N., et al. Constitutive lysosomal targeting and degradation of bovine endothelin-converting enzyme-1a mediated by novel signals in its alternatively spliced cytoplasmic tail. J. Biol. Chem. 274 (1999) 1509-1518
4. Funke-Kaiser H., et al. Characterization of the c-specific promoter of the gene encoding human endothelin-converting enzyme-1 (ECE-1). FEBS Lett. 466 (2000) 310-316
5. Funke-Kaiser H., et al. Regulation of the major isoform of human endothelin-converting enzyme-1 by a strong housekeeping promoter modulated by polymorphic microsatellites. J. Hypertens. 21 (2003) 2111-2124
6. Hofstra R.M., et al. A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. Am. J. Hum. Genet. 64 (1999) 304-308
7. Ikura T., et al. cDNA cloning and expression of bovine endothelin converting enzyme. Biochem. Biophys. Res. Commun. 203 (1994) 1417-1422
8. Kedzierski R.M., and Yanagisawa M. Endothelin system: the double-edged sword in health and disease. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 851-876
9. Korth P., Bohle R.M., Corvol P., and Pinet F. Cellular distribution of endothelin-converting enzyme-1 in human tissues. J. Histochem. Cytochem. 47 (1999) 447-462
10. Meidan R., Klipper E., Gilboa T., Muller L., and Levy N. Endothelin-converting enzyme-1, abundance of isoforms a-d and identification of a novel alternatively spliced variant lacking a transmembrane domain. J. Biol. Chem. 280 (2005) 40867-40874
11. Muller L., et al. Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease. J. Biol. Chem. 278 (2003) 545-555
12. Orzechowski H.-D., et al. Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells. J. Mol. Med. 75 (1997) 512-521
13. Orzechowski H.-D., et al. Transcriptional mechanism of protein kinase C-induced isoform-specific expression of the gene for endothelin-converting enzyme-1 in human endothelial cells. Mol. Pharmacol. 60 (2001) 1332-1342
14. Schmidt M., et al. Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). FEBS Lett. 356 (1994) 238-243
15. Schweizer A., et al. Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations. Biochem. J. 328 (1997) 871-877
16. Shimada K., Takahashi M., and Tanzawa K. Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells. J. Biol. Chem. 269 (1994) 18275-18278
17. Shimada K., et al. Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem. Biophys. Res. Commun. 207 (1995) 807-812
18. Shimada K., Takahashi M., Ikeda M., and Tanzawa K. Identification and characterization of two isoforms of an endothelin-converting enzyme-1. FEBS Lett. 371 (1995) 140-144
19. Shimada K., Takahashi M., Turner A.J., and Tanzawa K. Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11. Biochem. J. 315 (1996) 863-867
20. Turner A.J., Isaac R.E., and Coates D. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. BioEssays 23 (2001) 261-269
21. Valdenaire O., Rohrbacher E., and Mattei M.G. Organization of the gene encoding the human endothelin-converting enzyme (ECE-1). J. Biol. Chem. 270 (1995) 29794-29798
22. Valdenaire O., et al. A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization. Eur. J. Biochem. 264 (1999) 341-349
23. Xu D., et al. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78 (1994) 473-485
24. Yanagisawa H., et al. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development 125 (1998) 825-836
25. Yorimitsu K., et al. Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2. Biochem. Biophys. Res. Commun. 208 (1995) 721-727