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Volumn 11, Issue 2, 2005, Pages 105-115
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Quantitative structure-activity relationship by CoMFA for cyclic urea and nonpeptide-cyclic cyanoguanidine derivatives on wild type and mutant HIV-1 protease
a
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Author keywords
3D QSAR; CoMFA; HIV 1 protease mutants; Inhibitory cyclic urea and cyanoguanidine derivatives
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Indexed keywords
4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1,3 BIS[4 (HYDROXYMETHYL)BENZYL] 2H 1,3 DIAZEPIN 2 ONE;
AMPRENAVIR;
ANTIVIRUS AGENT;
CD4 ANTIGEN;
GUANIDINE DERIVATIVE;
HYDROGEN;
IMIDAZOLE;
INDINAVIR;
KETONE DERIVATIVE;
MOZENAVIR;
NELFINAVIR;
PROTEINASE;
PYRAZOLE DERIVATIVE;
RITONAVIR;
SAQUINAVIR;
SB 561;
SB 570;
SB 571;
SD 146;
TRIAZOLE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
UREA DERIVATIVE;
XK 234;
XNO 63;
XP 521;
XR 835;
XV 638;
XV 643;
XV 652;
XZ 442;
ANTIVIRAL ACTIVITY;
ARTICLE;
COMPARATIVE MOLECULAR FIELD ANALYSIS;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
CORRELATION COEFFICIENT;
DRUG MECHANISM;
DRUG STRUCTURE;
ENZYME INHIBITION;
HUMAN IMMUNODEFICIENCY VIRUS 1;
PREDICTION;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
QUANTITATIVE STRUCTURE ACTIVITY RELATION;
RELIABILITY;
STRUCTURE ACTIVITY RELATION;
STRUCTURE ANALYSIS;
THREE DIMENSIONAL IMAGING;
WILD TYPE;
ANTIVIRAL AGENTS;
DRUG EVALUATION, PRECLINICAL;
DRUG RESISTANCE, VIRAL;
GUANIDINES;
HIV PROTEASE INHIBITORS;
HIV-1;
HUMANS;
MODELS, MOLECULAR;
MUTATION;
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;
UREA;
HUMAN IMMUNODEFICIENCY VIRUS 1;
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EID: 33646238013
PISSN: 16102940
EISSN: 09485023
Source Type: Journal
DOI: 10.1007/s00894-004-0226-5 Document Type: Article |
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Times cited : (12)
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References (32)
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