Anti-p97/VCP antibodies: An autoantibody marker for a subset of primary biliary cirrhosis patients with milder disease?

Scandinavian Journal of Immunology

Volumn 63, Issue 5, 2006, Pages 376-382

  Miyachi, K ^a,i   Hosaka, H ^b   Nakamura, N ^b   Miyakawa, H ^c   Mimori, T ^d   Shibata, M ^e   Matsushima, S ^f   Chinoh, H ^g   Horigome, T ^g   Hankins, R W ^a   Zhang, M ^h   Fritzler, M J ^h  

^a First Diagnostic Division   (Japan)

^b Saiseikai Yokohama City Nanbu Hospital   (Japan)

^c TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e Kanto Teishin Hospital   (Japan)

^f NATIONAL HOSPITAL ORGANIZATION YOKOHAMA MEDICAL CENTER   (Japan)

^g NIIGATA UNIVERSITY   (Japan)

^h UNIVERSITY OF CALGARY   (Canada)

ⁱ Health Sciences Research Institute Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; P97 ANTIBODY; PROTEIN; PROTEIN P97; PYRUVATE DEHYDROGENASE COMPLEX; UNCLASSIFIED DRUG; VALOSIN CONTAINING PROTEIN; VCP ANTIBODY;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; FEMALE; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOPRECIPITATION; LIVER BIOPSY; LIVER FAILURE; LIVER FUNCTION; MALE; MITOCHONDRION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROGNOSIS;

AGED; AGED, 80 AND OVER; AUTOANTIBODIES; BIOLOGICAL MARKERS; CELL CYCLE PROTEINS; FEMALE; HUMANS; IMMUNOPRECIPITATION; LIVER; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; PROGNOSIS;

EID: 33646236776     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2006.01747.x     Document Type: Article

References (36)

1. Tan EM Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology Adv Immunol 1989 44 93 151
2. Fritzler MJ Manns MP Anti-mitochondrial antibodies Clin Appl Immunol Rev 2002 3 87 113
3. Muratori P Muratori L Gershwin ME et al. 'True' antimitochondrial antibody-negative primary biliary cirrhosis, low sensitivity of the routine assays, or both? Clin Exp Immunol 2004 135 154 8
4. Makinen D Fritzler MJ Davis P et al. Anticentromere antibodies in primary biliary cirrhosis Arthritis Rheum 1983 26 914 7
5. Szostecki C Guldner HH Will H Autoantibodies against 'nuclear dots' in primary biliary cirrhosis Semin Liver Dis 1997 17 71 8
6. Courvalin J-C Worman HJ Nuclear envelope protein autoantibodies in primary biliary cirrhosis Semin Liver Dis 1997 17 79 90
7. Miyachi K Shibata M Onozuka Y et al. Primary biliary cirrhosis sera recognize not only gp210 but also proteins of the p62 complex bearing N-acetyl glucosamine residues from rat liver nuclear envelope. Anti-p62 complex antibody in PBC Mol Biol Rep 1996 23 227 34
8. Ou Y Enarson P Rattner JB et al. The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence Clin Exp Immunol 2004 136 379 87
9. Fida S Myers MA Whittingham S et al. Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases J Autoimmun 2002 19 251 7
10. Itoh S Ichida T Yoshida T et al. Autoantibodies against a 210 kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis J Gastroenterol Hepatol 1998 13 257 65
11. Miyachi K Hankins RW Matsushima H et al. Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study J Autoimmun 2003 20 247 54
12. Klein R Berg PA Anti-M9 antibodies in sera from patients with primary biliary cirrhosis recognize an epitope of glycogen phosphorylase Clin Exp Immunol 1990 81 65 71
13. Takano S Mimori T Akizuki M et al. Serological diagnostic markers for patients having connective tissue diseases associated with autoimune hepatic diseases Arthritis Rheum 1992 3 Suppl. 215
14. Miyachi K Matsushima H Hankins RW et al. A novel antibody directed against a three-dimensional configuration of a 95-kDa protein in patients with autoimmune hepatic diseases Scand J Immunol 1998 47 63 8
15. Koller KJ Brownstein MJ Use of a cDNA clone to identify a supposed precursor protein containing valosin Nature 1987 325 542 5
16. DeLaBarre B Brunger AT Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains Nat Struct Biol 2003 10 856 63
17. Rabinovich E Kerem A Frohlich KU et al. AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation Mol Cell Biol 2002 22 626 34
18. Miyachi K Hirano Y Horigome T et al. Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibit in vitro nuclear envelope assembly Clin Exp Immunol 2004 136 568 73
19. Lerner MR Steitz JA Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus Proc Natl Acad Sci USA 1979 76 5495 9
20. Forman MS Nakamura M Mimori T et al. Detection of antibodies to small nuclear ribonucleoproteins and small cytoplasmic ribonucleoproteins using unlabeled cell extracts Arthritis Rheum 1985 28 1356 61
21. Fritzler MJ Lung C-C Hamel JC et al. Molecular characterization of golgin-245: a novel Golgi complex protein containing a granin signature J Biol Chem 1995 270 31262 8
22. Griffith KJ Chan EKL Hamel JC et al. Molecular characterization of a novel 97 kDa Golgi complex autoantigen recognized by autoimmune antibodies from patients with Sjögren's syndrome Arthritis Rheum 1997 40 1693 702
23. Nakagawa T Hirano Y Inomata A et al. Participation of a fusogenic protein, glyceraldehyde-3-phosphate dehydrogenase, in nuclear membrane assembly J Biol Chem 2003 278 20395 404
24. Sasagawa S Yamamoto A Ichimura T et al. In vitro nuclear assembly with affinity-purified nuclear envelope precursor vesicle fractions, PV1 and PV2 Eur J Cell Biol 1999 78 593 600
25. Smythe C Newport JW Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts Methods Cell Biol 1991 35 449 68
26. Zhang X Shaw A Bates PA et al. Structure of the AAA ATPase p97 Mol Cell 2000 6 1473 84
27. Neuwald AF Aravind L Spouge JL et al. AAA+: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes Genome Res 1999 9 27 43
28. Karata K Inagawa T Wilkinson AJ et al. Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH J Biol Chem 1999 274 26225 32
29. Mashima J Nagahama M Hatsuzawa K et al. N-ethylmaleimide-sensitive factor is associated with the nuclear envelope Biochem Biophys Res Commun 2000 274 559 64
30. Yamamoto S Tomita Y Nakamori S et al. Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence J Clin Oncol 2003 21 447 52
31. Yamamoto S Tomita Y Hoshida Y et al. Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastric carcinoma J Clin Oncol 2003 21 2537 44
32. Prince M Chetwynd A Newman W et al. Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years Gastroenterology 2002 123 1044 51
33. Nakano T Inoue K Hirohara J et al. Long-term prognosis of primary biliary cirrhosis (PBC) in Japan and analysis of the factors of stage progression in asymptomatic PBC (a-PBC) Hepatol Res 2002 22 250 60
34. Lafer EM Clathrin-protein interactions Traffic 2002 3 513 20
35. Zullig S Hengartner MO Cell biology. Tickling macrophages, a serious business Science 2004 304 1123 4
36. Hanayama R Tanaka M Miyasaka K et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice Science 2004 304 1147 50