Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: A multicenter study

Journal of Autoimmunity

Volumn 20, Issue 3, 2003, Pages 247-254

  Miyachi, Kiyomitsu ^a   Hankins, Raleigh W ^a   Matsushima, Hiroshi ^a   Kikuchi, Futoshi ^b   Inomata, Tetushi ^b   Horigome, Tuneyoshi ^b   Shibata, Minoru ^f   Onozuka, Yasushi ^f   Ueno, Yukihisa ^f   Hashimoto, Etsuko ^c   Hayashi, Naoaki ^c   Shibuya, Akitaka ^d   Amaki, Shuichi ^e   Miyakawa, Hiroshi ^f  

^a Hlth Sci Research Institute Inc   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f NONE

Author keywords

Anti nuclear envelope antibody; Anti p62 complex antibody; Primary biliary cirrhosis

Indexed keywords

ANTINUCLEAR ANTIBODY; CELL NUCLEUS MEMBRANE ANTIBODY; GLYCOPROTEIN GP 210 ANTIBODY; LAMIN B RECEPTOR ANTIBODY; LAMINA ASSOCIATED POLYPEPTIDE 2 ANTIBODY; PROTEIN ANTIBODY; PROTEIN P62 ANTIBODY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ;

ADULT; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; RAT; SERUM; STATISTICAL SIGNIFICANCE;

EID: 12444277805     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-8411(03)00033-7     Document Type: Article

References (38)

1. Tan E.M. Antinuclear antibody: diagnostic markers for autoimmune disease and probe for cell biology. Adv Immunol. 44:1989;93-151.
2. Mackay I.R. Primary biliary cirrhosis showing high titer of autoantibody; report of a case. N Engl J Med. 254:1958;185.
3. Leung P.S.C., Coppel R.L., Ansari A., Munoz S., Gershwin M.E. Antimitochondrial antibodies in primary biliary cirrhosis. Semin Liver Dis. 17:1997;61-69.
4. Bassendine M.F., Jones D.J., Yeaman S.J. Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis. Semin Liver Dis. 17:1997;49-60.
5. Makinen D., Fritzler M., Davis P., Sherlock S. Anticentromere antibodies in primary biliary cirrhosis. Arthritis Rhuem. 26:1983;914-917.
6. Szostecki C., Guldner H.H., Will H. Autoantibodies against nuclear dots in primary biliary cirrhosis. Semin Liver Dis. 17:1997;71-78.
7. Lozano F., Pares A., Borche L., Plana M., Gallart T., Rodes J., et al. Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis. Hepatology. 8:1988;930-938.
8. Shibata M, Ouya K, Hachiya T, Tamai K, Miyachi K, Horigome T et al. Detection of anti-gp210 antibodies in primary biliary cirhhosis by enzyme-linked immunosorbent assay with a synthesized polypeptide. In: Yamada M, Toda G, Tanaka T, editors. Liver and immunology. Progress in hepatology; vol 5 1999;P125-33.
9. Wesierska-Gadek J., Hohnenauer H., Hichman E., Penner E. Anti-gp210 antibodies in sera of patients with primary biliary cirrhosis. Identification of a 64 kD fragment of gp210 as a major epitope. Hum Antibodies Hybrid. 7:1996;167-174.
10. Kita K., Omata S., Horigome T. Purification and characterization of a nuclear pore glycoprotein complex containing p62. J Biochem. 113:1993;377-382.
11. Saito M., Kita K., Sekiya K., Omata S., Horigome T. Purification and molecular shape of a 144 kDa protein bearing N-acetylglucoseamine residue from rat liver nuclear envelope. J Biochem. 117:1995;47-53.
12. Haino M., Kawahire S., Omata S., Horigome T. Purification of a 60 kDa nuclear localization signal binding protein in rat liver nuclear envelopes and characterization of its properties. J Biochem. 113:1993;308-313.
13. Sune C., Hayashi T., Liu Y., Lane W.S., Young R.A., Garcia-Blanco M.A. CA150: a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1. Mol Cell Biol. 17:1997;6029-6039.
14. Shimada M., Saito M., Katakai T., Shimizu A., Ichimura T., Omata S., et al. Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150. J Biochem. 126:1999;1033-1042.
15. Wiesner R.H., LaRusso N.F., Ludwig J., Dickson E.R. Comparison of the clinicopathologic features in primary sclerosing cholangitis and primary biliary cirrhosis. Gastroenterology. 88:1985;108-114.
16. Scheuer P.J. Primary biliary cirrhosis. Proc R Soc Med. 60:1967;1257-1260.
17. Arnett F.C., Edworthy S., Block D.A., McShane D.J., Fries J.F., Cooper N.S., et al. The American Rheumatism Association 1987 revised criteria for rheumatoid arthritis. Arthitis Rheum. 31:1988;315-324.
18. Homma M., Tojo T., Akizuki M., Yamagata H. Criteria for Sjögren's syndrome in Japan. Scand J Rheumatol Suppl. 61:1986;26-27.
19. Shibata M., Ueno Y., Onozuka Y., Kawaguchi N., Oda Y., Hiwatashi T., et al. Autoantibodies against nuclear envelope in patients with primary biliary cirrhosis. Intern Hepatol Commun. 4:1995;46-53.
20. Imai N., Saito M., Denta K., Ichimura T., Omata S., Horigome T. Purification of 39 kDa and 50 kDa putative nucleoporins from rat liver nuclear envelope. Biochem (Life Sci Adv). 14:1995;59-66.
21. Laemmli U.K. Cleavage of structural proteins during the assembly of the heads of bacteriophage T4. Nature. 227:1970;680-685.
22. Towbin H., Steabelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets; procedures and some applications. Proc Natl Acad Sci USA. 76:1979;4350-4354.
23. Fregeau D.R., Davis P.A., Danner D.J., Ansari A., Coppel R.L., Dickson E.R., et al. Antimitochondrial antibodies of primary biliary cirrhosis recognize dihydrolipoamide acyltransferase and inhibit enzyme function of the branched chain alpha-ketoacid dehydrogenase complex. J Immunol. 142:1989;3815-3820.
24. Miyakawa H., Tanaka A., Kikuchi K., Matsushita M., Kitazawa E., Kawaguchi N., et al. Detection of antimitochondrial autoantibodies in immunofluorescence AMA negative patients with PBC using recombinant autoantigen. Hepatology. 34:2001;243-248.
25. Moteki S., Leung P.S.C., Coppel R.L., Dickson E.R., Kaplan M.M., Munoz S., et al. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. Hepatology. 24:1996;97-103.
26. Kawahire S., Takeuchi M., Gohshi T., Sasagawa S., Shimada M., Takahashi M., et al. cDNA cloning of nuclear localoization signal binding protein NBP60, a rat homologue of lamin B receptor, and identification of binding site of human lamin B receptor for nuclear localization signals and chromatin. J Biochem. 121:1997;881-889.
27. Lassoued K., Guilly M.N., Andre C., Paintrand M., Dhumeaux D., Danon F., et al. Autoantibodies 200 kD polypeptide(s) of the nuclear envelope: a new serologic marker of primary biliary cirrhosis. Clin Exp Immunol. 74:1988;283-288.
28. Nickowitz R.E., Wozniak P.W., Schaffner F., Worman H.J. Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary bilary cirrhosis. Gastroenterology. 106:1994;193-199.
29. Wesierska-Gadek J.W., Hohenauer H., Hitchman E., Penner E. Autoantibodies from patients with primary biliary cirrhosis prefetentially react with the amino-terminal domain of nuclear pore complex glycoprotein gp210. J Exp Med. 182:1995;1159-1162.
30. Bandin O., Courvalin J.C., Poupon R., Dubel L., Homberg J.C., Johanet C. Specificity and sensitivity of gp210 autoantibodies detected using an enzyme-linked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis. Hepatology. 23:1996;1020-1024.
31. Miyachi K., Shibata M., Onozuka Y., Kikuchi F., Imai N., Horigome T. Primary biliary cirrhosis sera recognize not only gp210 but also proteins of the p62 complex bearing N-acetylglucosamine residues from rat liver nuclear envelope. Anti-p62 complex antibody in PBC. Mol Biol Rep. 23:1996;227-234.
32. Wesierska-Gadek J.W., Hohenauer H., Hitchman E., Penner E. Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis. Gastroenterology. 110:1996;840-847.
33. Itoh S., Ichida T., Yoshida T., Hayakawa A., Uchida M., Tashiro T., et al. Autoantibodies against a 210 kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis. J Gastroenterol Hepatol. 13:1998;257-265.
34. Invernizzi P., Podda M., Battezzati P.M., Crosignani A., Zuin M., Hitchman E., et al. Autoantibodies against nuclear pore complex are associated with more active and severe liver disease in primary biliary cirrhosis. J Hepatol. 34:2001;366-372.
35. Starr C.M., D'Onofrio M., Park M.K., Hanover J.A. Primary sequence and heterologous expression of nuclear pore glycoprotein p62. J Cell Biol. 110:1990;1861-1871.
36. Carmo-Fonseca M., Kern H., Hurt E.C. Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization. Eur J Cell Biol. 55:1991;17-30.
37. Kinoshita H., Omagari K., Whittingham S., Kato Y., Ishibashi H., Sugi K., et al. Autoimmune cholangitis and primary biliary cirrhosis - an autoimmune enigma. Liver. 19:1999;122-128.
38. Tsuneyama K., Van de Water J., Van Thiel D., Leing P.S.C., Cha S., Nakanuma Y., et al. Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression. Hepatology. 21:1995;1031-1037.