Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or acetaminophen

Pharmacological Reports

Volumn 57, Issue 5, 2005, Pages 596-603

  Abdel Salam, Omar M E ^a   Baiuomy, Ayman R ^a   El Shenawy, Siham M ^a   Hassan, Nabila S ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Acetaminophen; Carbon tetrachloride; Liver injury rat; Pentoxifylline

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GLYCOGEN; PARACETAMOL; PENTOXIFYLLINE;

ACUTE DISEASE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COMPUTER ANALYSIS; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; GLYCOGEN ANALYSIS; HISTOPATHOLOGY; IMAGE ANALYSIS; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER STRUCTURE; MALE; MORPHOMETRICS; NONHUMAN; PROTEIN CONTENT; QUANTITATIVE ANALYSIS; RAT; STAINING; TISSUE SECTION;

EID: 33646188823     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Abdel-Salam OME, Baiuomy AR, El-Shenawy SM, Arbid MS: The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat. Pharmacol Res, 2003, 47, 331-340.
2. Beales D, McLean AE: Protection in the late stages of acetaminophen-induced liver cell injury with fructose, cyclosporin A and trifluoperazine. Toxicology, 1996, 107, 201-208.
3. Belfield A, Goldberg DM: Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine. Enzyme, 1971, 12, 561-573.
4. Carneiro-Filho BA, Souza ML, Lima AA, Ribeiro RA: The effect of tumour necrosis factor (TNF) inhibitors in Clostridium difficile toxin-induced paw oedema and neutrophil migration. Pharmacol Toxicol, 2001, 88, 313-318.
5. Crowley LV. The Reitman-Frankel colorimetric transaminase procedure in suspected myocardial infarction. Clin Chem, 1967, 13, 482-487.
6. Demir S, Inal-Erden M: Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. Clin Chim Acta, 1998, 275, 127-135.
7. Desmouliere A, Xu G, Costa AM, Yousef IM, Gabbiani G, Tuchweber B: Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells. J Hepatol, 1999, 30, 621-631.
8. Dormandy JA: Pharmacologic treatment of venous leg ulcers. J Cardiovasc Pharmacol, 1995,25, Suppl 2, S61-S65.
9. Hsu CT, Schichijo K, Ito M, Sekine I: The effect of chemical sympathectomy on acute liver injury induced by carbon tetrachloride in spontaneously hypertensive rats. J Auton Nerv Syst, 1993, 43, 91-96.
10. Ito Y, Bethea NW, Abril ER, McCuskey RS: Early hepatic microvascular injury in response to acetaminophen toxicity. Microcirculation, 2003, 10, 391-400.
11. Jaeschke H: Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. J Pharmacol Exp Ther, 1990, 255, 935-941.
12. Kaye AD, Ibrahim IN, Kadowitz PJ, Nossaman BD: Analysis of responses to pentoxifylline in the pulmonary vascular bed of the cat. Crit Care Med, 1996, 24, 263-267.
13. Knight TR, Kurtz AA, Bajt ML, Hinson JA, Jaeschke H: Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol Sci, 2001, 62, 212-220.
14. Lee KS, Cottam HB, Houglum K, Wasson DB, Carson D, Chojkier M: Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity. Am J Physiol, 1997, 273, G1094-G1100.
15. Mandell GL: Cytokines, phagocytes, and pentoxifylline. J Cardiovasc Pharmacol, 1995, 25, Suppl 2, S20-S22.
16. Marzi I, Maier M, Herzog C, Bauer M: Influence of pentoxifylline and albifylline on liver microcirculation and leukocyte adhesion after hemorrhagic shock in the rat. J Trauma, 1996, 40, 90-96.
17. Matzky I, Darius H, Schror K: The release of prostacyclin (PG12) by pentoxifylline from human vascular tissue. Arzneimittelforschung, 1982, 32, 1315-1318.
18. McDonald RJ: Pentoxifylline reduces injury to isolated lungs perfused with human neutrophils. Am Rev Respir Dis, 1991, 144, 1347-1350.
19. Montosi G, Garuti C, Iannone A, Pietrangelo A: Spatial and temporal dynamics of hepatic stellate cell activation during oxidant-stress-induced fibrogenesis. Am J Pathol, 1998, 152, 1319-1326.
20. Novick WJ, Sullivan G, Mandell G: New pharmacological studies with pentoxifylline. Biorheology, 1990, 27, 449-454.
21. Peng XX, Currin RT, Thurman RG, Lemasters JJ: Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rats. Transplantation, 1995, 59, 1537-1541.
22. Peterson TC, Neumeister M: Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism. Immunopharmacology, 1996, 31, 183-193.
23. Raetsch C, Jia JD, Boigk G, Bauer M, Hahn E G, Riecken E-O, Schuppan D: Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis. Gut, 2002, 50, 241-247.
24. Seiffge D, Bissinger T, Kremer E, Laux V, Schleyerbach R: Inhibitory effects of pentoxifylline on LPS-induced leukocyte adhesion and macromolecular extravasation in the microcirculation. Inflamm Res, 1995, 44, 281-286.
25. Shirin H, Bruck R, Aeed H, Frenkel D, Kenet G, Zaidel L, Avni Y et al.: Pentoxifylline prevents concanavalin A-induced hepatitis by reducing tumor necrosis factor alpha levels and inhibiting adhesion of T lymphocytes to extracellular matrix. J Hepatol, 1998, 29, 60-67.
26. Silomon M, Pizanis A, Larsen R, Rose S: Pentoxifylline prevention of altered hepatocyte calcium regulation during hemorrhagic shock/ resuscitation. Crit Care Med, 1998, 26, 494-500.
27. Smith GS, Nadig DE, Kokoska ER, Solomon H, Tiniakos DG, Miller TA: Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats. J Surg Res, 1998, 80, 252-258.
28. Szczepanik AM, Wordliczek J, Serednicki W, Siedlar M, Czupryna A: Pentoxifylline does not affect nociception if administered postoperatively. Pol J Pharmacol, 2004, 56, 611-616.
29. Tanaka N, Tanaka K, Nagashima Y, Kondo M, Sekihara H: Nitric oxide increases hepatic arterial blood flow in rats with carbon tetrachloride-induced acute hepatic injury. Gastroenterology, 1999, 117, 173-180.
30. Ward A, Clissold SP: Pentoxifylline. A review of its pharmacodynarnic and pharmacokinetic properties, and its therapeutic efficacy. Drugs, 1987, 34, 50-97.
31. Weiss JM, Vanscheidt W, Pilarski KA, Weyl A, Peschen M, Schopf E, Vestweber D et al.: Pentoxifylline inhibits tumor necrosis factor-alpha (TNF alpha)-induced T-1ymphoma cell adhesion to endothelioma cells. J Invest Dermatol, 1995,104, 824-828.
32. Windmeier C, Gressner AM: Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen Pharmacol, 1997, 29, 181-196.
33. Wu J, Zern MA: Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol, 2000, 35, 665-672.