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Volumn 29, Issue 1, 1998, Pages 60-67

Pentoxifylline prevents concanavalin A-induced hepatitis by reducing tumor necrosis factor α levels and inhibiting adhesion of T lymphocytes to extracellular matrix

Author keywords

Cytokines; Hepatitis; Pentoxifylline

Indexed keywords

CONCANAVALIN A; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0032125209     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80179-7     Document Type: Article
Times cited : (27)

References (47)
  • 2
    • 0027944823 scopus 로고
    • Pentoxifylline in vivo down-regulates the release of IL-1/β, IL-6, IL-8 and tumor necrosis factor by human peripheral blood mononuclear cells
    • Neuner P, Klosner G, Schauer E, Pourmojib N, Macheiner W, Grunwald C, et al. Pentoxifylline in vivo down-regulates the release of IL-1/β, IL-6, IL-8 and tumor necrosis factor by human peripheral blood mononuclear cells. Immunology. 83:1994;262-267.
    • (1994) Immunology , vol.83 , pp. 262-267
    • Neuner, P.1    Klosner, G.2    Schauer, E.3    Pourmojib, N.4    Macheiner, W.5    Grunwald, C.6
  • 3
    • 0027228499 scopus 로고
    • Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: A prospective randomized trial
    • Attal M, Huguet F, Rubie H, Charlet JP, Schlaifer D, Huynh A, et al. Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective randomized trial. Blood. 82:1993;732-736.
    • (1993) Blood , vol.82 , pp. 732-736
    • Attal, M.1    Huguet, F.2    Rubie, H.3    Charlet, J.P.4    Schlaifer, D.5    Huynh, A.6
  • 5
    • 0031054601 scopus 로고    scopus 로고
    • Pentoxifylline in vivo and in vitro down-regulates the expression of the intercellular adhesion molecule-1 in monocytes
    • Neuner P, Klosner G, Ponrmojib M, Knobler R, Schwarz T. Pentoxifylline in vivo and in vitro down-regulates the expression of the intercellular adhesion molecule-1 in monocytes. Immunology. 90:1997;435-439.
    • (1997) Immunology , vol.90 , pp. 435-439
    • Neuner, P.1    Klosner, G.2    Ponrmojib, M.3    Knobler, R.4    Schwarz, T.5
  • 6
    • 0026656897 scopus 로고
    • Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation
    • Wang P, Ba FZ, Morrison M.H, Ayala A, Chaudry IH. Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation. Surgery. 112:1992;451-458.
    • (1992) Surgery , vol.112 , pp. 451-458
    • Wang, P.1    Ba, F.Z.2    Morrison, M.H.3    Ayala, A.4    Chaudry, I.H.5
  • 7
    • 0030434274 scopus 로고    scopus 로고
    • Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock
    • Jilg S, Baxsig J, Leist M, Kusters S, Volk HD, Wendel A. Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock. J Pharmacol Exp Ther. 278:1996;421-431.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 421-431
    • Jilg, S.1    Baxsig, J.2    Leist, M.3    Kusters, S.4    Volk, H.D.5    Wendel, A.6
  • 8
    • 0029893362 scopus 로고    scopus 로고
    • Acute hemodynamic responses and inhibition of tumor necrosis factor-alpha by pentoxifylline in rats with cirrhosis
    • Soupison T, Yang S, Bernard C, Moreau R, Kirstetter P, D'Almeida M, et al. Acute hemodynamic responses and inhibition of tumor necrosis factor-alpha by pentoxifylline in rats with cirrhosis. Clin Sci. 91:1996;29-33.
    • (1996) Clin Sci , vol.91 , pp. 29-33
    • Soupison, T.1    Yang, S.2    Bernard, C.3    Moreau, R.4    Kirstetter, P.5    D'Almeida, M.6
  • 9
    • 0026643743 scopus 로고
    • A T cell-dependent experimental liver injury in mice inducible by concanavalin A
    • Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest. 90:1992;196-203.
    • (1992) J Clin Invest , vol.90 , pp. 196-203
    • Tiegs, G.1    Hentschel, J.2    Wendel, A.3
  • 10
    • 0028795171 scopus 로고
    • Concanavalin A -induced T cell mediated hepatic injury in mice: The role of tumor necrosis factor
    • Gantner F, Leist M, Loshe AW, Germann PG, Tiegs G. Concanavalin A -induced T cell mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology. 21:1995;190-198.
    • (1995) Hepatology , vol.21 , pp. 190-198
    • Gantner, F.1    Leist, M.2    Loshe, A.W.3    Germann, P.G.4    Tiegs, G.5
  • 12
    • 0027938118 scopus 로고
    • Immunotoxicology of host-response-mediated experimental liver injury
    • Tiegs G. Immunotoxicology of host-response-mediated experimental liver injury. J Hepatol. 21:1994;890-903.
    • (1994) J Hepatol , vol.21 , pp. 890-903
    • Tiegs, G.1
  • 13
    • 0028300351 scopus 로고
    • T cell activation-associated hepatic injury: Mediation by tumor necrosis factor and protection by interleukin 6
    • Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factor and protection by interleukin 6. J Exp Med. 179:1994;1529-1537.
    • (1994) J Exp Med , vol.179 , pp. 1529-1537
    • Mizuhara, H.1    O'Neill, E.2    Seki, N.3    Ogawa, T.4    Kusunoki, C.5    Otsuka, K.6
  • 14
    • 15844425587 scopus 로고    scopus 로고
    • Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis
    • Mizuhara H, Uno M, Seki N, Yamashita M, Yamaoka M, Ogawa T, et al. Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis. Hepatology. 23:1996;1608-1615.
    • (1996) Hepatology , vol.23 , pp. 1608-1615
    • Mizuhara, H.1    Uno, M.2    Seki, N.3    Yamashita, M.4    Yamaoka, M.5    Ogawa, T.6
  • 15
    • 0031049463 scopus 로고    scopus 로고
    • Analysis of Arg-Gly Asp mimetics and soluble receptor of tumour necrosis factor as therapeutic modalities for concanavalin A-induced hepatitis in mice
    • Bruck R, Shirin H, Hershkoviz R, Lider O, Kenet G, Aeed H, et al. Analysis of Arg-Gly Asp mimetics and soluble receptor of tumour necrosis factor as therapeutic modalities for concanavalin A-induced hepatitis in mice. Gut. 40:1997;133-138.
    • (1997) Gut , vol.40 , pp. 133-138
    • Bruck, R.1    Shirin, H.2    Hershkoviz, R.3    Lider, O.4    Kenet, G.5    Aeed, H.6
  • 16
    • 0030111451 scopus 로고    scopus 로고
    • Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines
    • Leist M, Auer-Barth S, Wendel A. Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines. J Pharmacol Exp Ther. 276:1996;968-976.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 968-976
    • Leist, M.1    Auer-Barth, S.2    Wendel, A.3
  • 18
    • 0022499422 scopus 로고
    • Experimental and clinical study of lactulose in obstructive jaundice
    • Pain JA, Bailey ME. Experimental and clinical study of lactulose in obstructive jaundice. Br J Surg. 73:1986;775-778.
    • (1986) Br J Surg , vol.73 , pp. 775-778
    • Pain, J.A.1    Bailey, M.E.2
  • 19
    • 0027250795 scopus 로고
    • Effect of antitumour necrosis factor treatment on circulating tumour necrosis factor levels and mortality after surgery in jaundiced mice
    • Bemelmans MHA, Gouma DJ, Greve JW, Buurman WA. Effect of antitumour necrosis factor treatment on circulating tumour necrosis factor levels and mortality after surgery in jaundiced mice. Br J Surg. 80:1993;1055-1058.
    • (1993) Br J Surg , vol.80 , pp. 1055-1058
    • Bemelmans, M.H.A.1    Gouma, D.J.2    Greve, J.W.3    Buurman, W.A.4
  • 20
    • 0025278562 scopus 로고
    • Lactulose inhibits endotoxin tumour necrosis factor production by monocytes. An in vitro study
    • Greve JW, Gouma DJ, Leeuwen PAM, Buurman WA. Lactulose inhibits endotoxin tumour necrosis factor production by monocytes. An in vitro study. Gut. 31:1990;198-203.
    • (1990) Gut , vol.31 , pp. 198-203
    • Greve, J.W.1    Gouma, D.J.2    Leeuwen, P.A.M.3    Buurman, W.A.4
  • 21
    • 0025363922 scopus 로고
    • Regulated expression and binding of three VLA (β1) integrin receptors on T cells
    • Shimizu Y, van Saventer GA, Horgan KJ, Shaw KJ. Regulated expression and binding of three VLA (β1) integrin receptors on T cells. Nature. 345:1990;250-253.
    • (1990) Nature , vol.345 , pp. 250-253
    • Shimizu, Y.1    Van Saventer, G.A.2    Horgan, K.J.3    Shaw, K.J.4
  • 22
    • 0027406729 scopus 로고
    • Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp cell adhesion motif
    • Greenspoon N, Hershkoviz R, Alon R, Varon D, Shemkman B, Marx G, et al. Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp cell adhesion motif. Biochemistry. 32:1993;1001-1008.
    • (1993) Biochemistry , vol.32 , pp. 1001-1008
    • Greenspoon, N.1    Hershkoviz, R.2    Alon, R.3    Varon, D.4    Shemkman, B.5    Marx, G.6
  • 23
    • 0028263876 scopus 로고
    • + T lymphocyte binding to fibronectin and immune cell accumulation in inflammatory sites by novel nonpeptidic mimetics of the Arg-Gly-Asp cell adhesion motif
    • + T lymphocyte binding to fibronectin and immune cell accumulation in inflammatory sites by novel nonpeptidic mimetics of the Arg-Gly-Asp cell adhesion motif. Clin Exp Immunol. 95:1994;270-276.
    • (1994) Clin Exp Immunol , vol.95 , pp. 270-276
    • Hershkoviz, R.1    Greenspoon, N.2    Mekori, Y.A.3    Hadari, R.4    Alon, R.5    Lider, O.6
  • 28
    • 0020661758 scopus 로고
    • Galactosamine hepatitis, endotoxemia and lactulose
    • Van Vugt H, van Gool J, Thomas LLM. Galactosamine hepatitis, endotoxemia and lactulose. Hepatology. 3:1983;236-240.
    • (1983) Hepatology , vol.3 , pp. 236-240
    • Van Vugt, H.1    Van Gool, J.2    Thomas, L.L.M.3
  • 29
    • 0029935225 scopus 로고    scopus 로고
    • Increased concentrations of tumor necrosis factor (TNF) and soluble TNF receptors in biliary obstruction in mice; Soluble TNF receptors are prognostic factors for mortality
    • Bemelmans MH, Greve JW, Gouma DJ, Buurman WA. Increased concentrations of tumor necrosis factor (TNF) and soluble TNF receptors in biliary obstruction in mice; soluble TNF receptors are prognostic factors for mortality. Gut. 38:1996;447-453.
    • (1996) Gut , vol.38 , pp. 447-453
    • Bemelmans, M.H.1    Greve, J.W.2    Gouma, D.J.3    Buurman, W.A.4
  • 30
    • 0023189396 scopus 로고
    • Pentoxifylline: A review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy
    • Ward A, Clissold SP. Pentoxifylline: a review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy. Drugs. 34:1987;50-97.
    • (1987) Drugs , vol.34 , pp. 50-97
    • Ward, A.1    Clissold, S.P.2
  • 31
    • 0025998492 scopus 로고
    • Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation
    • Bianco JA, Appelbaum FR, Nemunaitis J, Almgren J, Andrews F, Ketner P, et al. Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood. 78:1991;1205-1211.
    • (1991) Blood , vol.78 , pp. 1205-1211
    • Bianco, J.A.1    Appelbaum, F.R.2    Nemunaitis, J.3    Almgren, J.4    Andrews, F.5    Ketner, P.6
  • 32
    • 0022967477 scopus 로고
    • Effects of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells
    • Bessler H, Gilgal R, Djaldetti M, Zahavi I. Effects of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells. J Leukocyts Biol. 40:1986;747-757.
    • (1986) J Leukocyts Biol , vol.40 , pp. 747-757
    • Bessler, H.1    Gilgal, R.2    Djaldetti, M.3    Zahavi, I.4
  • 33
    • 0024501727 scopus 로고
    • Lipopolysaccharide induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP
    • Tannenbaum CS, Hamilton TA. Lipopolysaccharide induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP. J Immunol. 142:1989;1274-1280.
    • (1989) J Immunol , vol.142 , pp. 1274-1280
    • Tannenbaum, C.S.1    Hamilton, T.A.2
  • 34
    • 0025282043 scopus 로고
    • Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
    • Han J, Thompson P, Beutler B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J Exp Med. 172:1990;391-394.
    • (1990) J Exp Med , vol.172 , pp. 391-394
    • Han, J.1    Thompson, P.2    Beutler, B.3
  • 35
    • 0026026007 scopus 로고
    • Cyclic nucleotides differentially regulate the synthesis of tumor necrosis factor-alpha and interleukin-1 beta by human mononuclear cells
    • Endres S, Fulle HJ, Sinha B, Stoll D, Dinarello CA, Gerzer R, et al. Cyclic nucleotides differentially regulate the synthesis of tumor necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology. 72:1991;56-60.
    • (1991) Immunology , vol.72 , pp. 56-60
    • Endres, S.1    Fulle, H.J.2    Sinha, B.3    Stoll, D.4    Dinarello, C.A.5    Gerzer, R.6
  • 36
    • 0025059497 scopus 로고
    • Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality
    • Noel P, Nelson S, Bokulic R, Bagby GJ, Lippton H, Lipscomb G, et al. Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality. Life Sci. 47:1990;1023-1029.
    • (1990) Life Sci , vol.47 , pp. 1023-1029
    • Noel, P.1    Nelson, S.2    Bokulic, R.3    Bagby, G.J.4    Lippton, H.5    Lipscomb, G.6
  • 37
    • 0026801421 scopus 로고
    • Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy
    • Akerman P, Cote P, Yang SQ, Mclain C, Nelson S, Bagby GJ, et al. Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy. Am J Physiol. 263:1992;G579-G585.
    • (1992) Am J Physiol , vol.263
    • Akerman, P.1    Cote, P.2    Yang, S.Q.3    Mclain, C.4    Nelson, S.5    Bagby, G.J.6
  • 38
    • 0026507534 scopus 로고
    • Tumor necrosis factor stimulates DNA synthesis of mouse hepatocytes in primary culture and is suppressed by transforming growth factor β and interleukin 6
    • Satoh M, Yamazaki M. Tumor necrosis factor stimulates DNA synthesis of mouse hepatocytes in primary culture and is suppressed by transforming growth factor β and interleukin 6. J Cell Physiol. 150:1992;134-139.
    • (1992) J Cell Physiol , vol.150 , pp. 134-139
    • Satoh, M.1    Yamazaki, M.2
  • 39
    • 0025730216 scopus 로고
    • Lymphocyte interactions with extracellular matrix
    • Shimizu Y, Shaw S. Lymphocyte interactions with extracellular matrix. FASEB J. 5:1990;2292-2297.
    • (1990) FASEB J , vol.5 , pp. 2292-2297
    • Shimizu, Y.1    Shaw, S.2
  • 40
    • 0024444326 scopus 로고
    • Cytokine-induced respiratory burst of human neutrophils depends on extracellular matrix proteins and CD11/CD18 integrins
    • Nathan C, Srimal S, Farber C, Sanchez E, Kabbash L, Asch A, et al. Cytokine-induced respiratory burst of human neutrophils depends on extracellular matrix proteins and CD11/CD18 integrins. J Cell Biol. 109:1989;1341-1349.
    • (1989) J Cell Biol , vol.109 , pp. 1341-1349
    • Nathan, C.1    Srimal, S.2    Farber, C.3    Sanchez, E.4    Kabbash, L.5    Asch, A.6
  • 41
    • 0025141731 scopus 로고
    • Pretreatment with pentoxifylline improves the hemodynamic and histologic changes and decreases neutrophil adhesiveness in a pig fecal peritonitis model
    • Tighe D, Moss R, Hynd J, Boghossian S, al-Saady N, Heath MF, et al. Pretreatment with pentoxifylline improves the hemodynamic and histologic changes and decreases neutrophil adhesiveness in a pig fecal peritonitis model. Crit Care Med. 18:1990;184-189.
    • (1990) Crit Care Med , vol.18 , pp. 184-189
    • Tighe, D.1    Moss, R.2    Hynd, J.3    Boghossian, S.4    Al-Saady, N.5    Heath, M.F.6
  • 42
    • 0025162668 scopus 로고
    • Attenuation of tumor necrosis factor-induced endothelial cell cytotoxicity and neutrophil chemiluminescence
    • Zheng J, Crowley J, Chan JH, et al. Attenuation of tumor necrosis factor-induced endothelial cell cytotoxicity and neutrophil chemiluminescence. Am Rev Respir Dis. 142:1990;1073-1078.
    • (1990) Am Rev Respir Dis , vol.142 , pp. 1073-1078
    • Zheng, J.1    Crowley, J.2    Chan, J.H.3
  • 43
    • 0026555111 scopus 로고
    • Pentoxifylline modulates activation of human neutrophils by amphotericin B in vitro
    • Sullivan GW, Carper HT, Mandell GL. Pentoxifylline modulates activation of human neutrophils by amphotericin B in vitro. Antimicrob Agents Chemother. 36:1992;408-416.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 408-416
    • Sullivan, G.W.1    Carper, H.T.2    Mandell, G.L.3
  • 44
    • 0026779742 scopus 로고
    • Penyoxifylline inhibits interleukin-2-induced toxicity in C57BL/6 mice but preserves antitumor efficacy
    • Edwards MJ, Heniford BT, Klar EA, Doak KW, Miller FN. Penyoxifylline inhibits interleukin-2-induced toxicity in C57BL/6 mice but preserves antitumor efficacy. J Clin Invest. 90:1992;637-641.
    • (1992) J Clin Invest , vol.90 , pp. 637-641
    • Edwards, M.J.1    Heniford, B.T.2    Klar, E.A.3    Doak, K.W.4    Miller, F.N.5
  • 45
    • 0010384783 scopus 로고
    • Effect of pentoxifylline on interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF alpha) induction of intercellular adhesion molecule-1 (ICAM-1) expression on human normal keratinocytes and Langerhans cells
    • Fraissinette AD, Berman B, Duncan MR, Lefevre L. Effect of pentoxifylline on interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF alpha) induction of intercellular adhesion molecule-1 (ICAM-1) expression on human normal keratinocytes and Langerhans cells. Eur J Dermatol. 23:1992;104-114.
    • (1992) Eur J Dermatol , vol.23 , pp. 104-114
    • Fraissinette, A.D.1    Berman, B.2    Duncan, M.R.3    Lefevre, L.4
  • 46
    • 0028179914 scopus 로고
    • TNF-α associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation
    • Hershkoviz R, Cahalon L, Miron S, Alon R, Sapir T, Akiyama S, et al. TNF-α associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation. J Immunol. 153:1994;554-565.
    • (1994) J Immunol , vol.153 , pp. 554-565
    • Hershkoviz, R.1    Cahalon, L.2    Miron, S.3    Alon, R.4    Sapir, T.5    Akiyama, S.6
  • 47
    • 85030338513 scopus 로고    scopus 로고
    • Pentoxifylline enhances response of chronic hepatitis C to interferon α2b: Interim report of a double-blind randomized controlled trial
    • (suppl 1): C01/045.
    • Lebovics E, Casellas A, Dworkin B, Chan S, Rosenthal WS. Pentoxifylline enhances response of chronic hepatitis C to interferon α2b: interim report of a double-blind randomized controlled trial. J Hepatol. 1996;25. (suppl 1): C01/045.
    • (1996) J Hepatol , pp. 25
    • Lebovics, E.1    Casellas, A.2    Dworkin, B.3    Chan, S.4    Rosenthal, W.S.5


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