The immunoregulatory effects of gangliosides involve immune deviation favoring type-2 T cell responses

Journal of Leukocyte Biology

Volumn 79, Issue 3, 2006, Pages 586-595

  Crespo, Fabian A ^a   Sun, Xichun ^a   Cripps, James G ^a   Fernandez Botran, Rafael ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Immunoregulation; Interferon ; Interleukin 4

Indexed keywords

CD1D ANTIBODY; CELL ANTIBODY; GAMMA INTERFERON; GANGLIOSIDE; INTERLEUKIN 4; IMMUNOSUPPRESSIVE AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL TYPE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL DIFFERENTIATION; DOWN REGULATION; DRUG EFFECT; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NEOPLASM; TH2 CELL; UPREGULATION;

MURINAE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DOWN-REGULATION; FEMALE; GANGLIOSIDES; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-4; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS; TH2 CELLS; UP-REGULATION;

EID: 33646118015     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0705395     Document Type: Article

References (41)

1. Ledeen, R. W., Yu, R. K. (1982) Gangliosides: structure, isolation and analysis. Methods Enzymol. 83, 139-191.
2. Lloyd, K. O., Furukawa, K. (1998) Biosynthesis and functions of gangliosides: recent advances. Glycoconj. J. 15, 627-636.
3. Valentino, L. A., Ladisch, S. (1992) Localization of shed human tumor gangliosides: association with serum lipoproteins. Cancer Res. 52, 810-814.
4. Spitalnik, S. L., Spitalnik, P. F., Dubois, C., Mulshine, J., Magnani, J. L., Cuttitta, F., Civin, C. I., Minna, J. D., Ginsburg, V. (1986) Glycolipid antigen expression in human lung cancer. Cancer Res. 46, 4751-4755.
5. Fuentes, R., Allman, R., Mason, M. D. (1997) Ganglioside expression in lung cancer cell lines. Lung Cancer 18, 21-22.
6. Grant, S. C., Kostakoglu, C. L., Kris, M. G., Yeh, S. D. J., Larson, S. M., Finn, R. D., Oettgen, H. F., Cheung, N-K. V. (1996) Targeting of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: a pilot trial. Eur. J. Nucl. Med. 23, 145-149.
7. Rampersaud, A. A., Oblinger, J. L., Ponnappan, R. K., Burry, R. W., Yates, A. J. (1999) Gangliosides and growth factor receptor regulation. Biochem. Soc. Trans. 27, 415-422.
8. Sorice, M., Longo, A., Garofalo, T., Mattei, V., Misasi, R., Pavan, A. (2004) Role of GM3-enriched microdomains in signal transduction regulation in T lymphocytes. Glycoconj. J. 20, 63-70.
9. Krishnan, S., Nambiar, M. P., Warke, V. G., Fisher, C. U., Mitchell, J., Delaney, N., Tsokos, G. C. (2004) Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J. Immunol. 172, 7821-7831.
10. Marmor, M. D., Julius, M. (2001) Role for lipid rafts in regulating interleukin-2 receptor signaling. Blood 98, 1489-1497.
11. McKallip, R., Li, R., Ladisch, S. (1999) Tumor gangliosides inhibit the tumor-specific immune response. J. Immunol. 163, 3718-3726.
12. Dix, A. R., Brooks, W. H., Roszman, T. L., Morford, L. A. (1999) Immune defects observed in patients with primary malignant brain tumors. J. Neuroimmunol. 100, 216-232.
13. Irani, D. N., Lin, K-I., Griffin, D. E. (1996) Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells. J. Immunol. 157, 4333-4340.
14. Lu, P., Sharom, F. J. (1996) Immunosuppression by YAC-1 lymphoma: role of shed gangliosides. Cell. Immunol. 173, 22-32.
15. Massa, P. T., Wu, C. (1996) Modulation of major histocompatibility complex class I genes by interferon-γ and ganglioside GT1b in astrocytes: involvement of protein tyrosine phosphatases. J. Neurochem. 67, 1831-1839.
16. Deng, W., Li, R., Ladisch, S. (2000) Influence of cellular ganglioside depletion on tumor formation. J. Natl. Cancer Inst. 92, 912-917.
17. Irani, D. N. (1998) Brain-derived gangliosides induce cell cycle arrest in a murine T cell line. J. Neuroimmunol. 87, 11-16.
18. Zhou, J., Shao, H., Cox, N. R., Barker, H. J., Ewald, S. J. (1998) Gangliosides enhance apoptosis of thymocytes. Cell. Immunol. 183, 90-98.
19. Sietsma, H., Nijhof, W., Dontje, B., Vellenga, E., Kamps, W. A., Kok, J. W. (1998) Inhibition of hemopoiesis in vitro by neuroblastoma-derived gangliosides. Cancer Res. 58, 4840-4844.
20. Sietsma, H., Kamps, W. A., Dontje, B., Hendriks, D., Kok, J. W., Vellenga, E., Nijhof, W. (1999) Leukemia-induced bone marrow depression: effects of gangliosides on erythroid cell production. Int. J. Cancer 82, 92-97.
21. Heitger, A., Ladisch, S. (1996) Gangliosides block antigen presentation by human monocytes. Biochim. Biophys. Acta 1303, 161-168.
22. Shurin, G. V., Shurin, M. R., Bykovskaia, S., Shogan, S., Lotze, M. T., Barksdale Jr., E. M. (2001) Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function. Cancer Res. 61, 363-369.
23. Vangsted, A. J., Clausen, H., Kjeldsen, T. B., White, T., Sweeney, B., Hakomori, S. I., Drivsholm, L., Zeuthen, J. (1991) Immunological detection of a small cell lung cancer-associated ganglioside (Fuc-GM1) antigen in serum. Cancer Res. 51, 2879-2884.
24. Li, R. X., Ladisch, S. (1991) Shedding of human neuroblastoma gangliosides. Biochim. Biophys. Acta 1083, 57-64.
25. Kong, Y., Li, R., Ladisch, S. (1998) Natural forms of shed tumor gangliosides. Biochim. Biophys. Acta 1394, 43-56.
26. Chang, F., Li, R., Ladisch, S. (1997) Shedding of gangliosides by human medulloblastoma cells. Exp. Cell Res. 234, 341-346.
27. Santin, A. D., Ravindranath, M. H., Bellone, S., Muthugounder, S., Palmieri, M., O'Brien, T. J., Roman, J., Cannon, M. J., Pecorelli, S. (2004) Increased levels of gangliosides in the plasma and ascitic fluid of patients with advanced ovarian cancer. BJOG 111, 613-618.
28. Zou, J. P., Morford, L. A., Chougnet, C., Dix, A. R., Brooks, A. G., Torres, N., Shuman, J. D., Coligan, J. E., Brooks, W. H., Roszman, T. L., Shearer, G. M. (1999) Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers. J. Immunol. 162, 4882-4892.
29. Rayman, P., Wesa, A. K., Richmond, A. L., Das, T., Biswas, K., Raval, G., Storkus, W. J., Tannenbaum, C., Novick, A., Bukowski, R., Finke, J. (2004) Effect of renal carcinomas on the development of type 1 T-cell responses. Clin. Cancer Res. 10, 6360S-6366S.
30. Fernandez-Botran, R., Chilton, P. M., Ma, Y., Windsor, J. L., Street, N. E. (1997) The production of soluble interleukin-4 receptors is preferentially regulated by the murine Th2 cell subset. Cytokine 9, 166-177.
31. Rozen, S., Skaletsky, H. (2000) Primer3 on the WWW for general users and for biologist programmers. In Bioinformatics Methods and Protocols in the Series Methods in Molecular Biology (S. Krawetz, S. Misener, eds.), Totowa, NJ, Humana, 365-386.
32. H2 response and in immunoglobulin E production. Science 270, 1845-1847.
33. Joyce, S. (2001) CD1d and natural T cells: how their properties jump-start the immune system. Cell. Mol. Life Sci. 58, 442-469.
34. Shamshiev, A., Donda, A., Carena, I., Mori, L., Kappos, L., De Libero, G. (1999) Self glycolipids as T-cell autoantigens. Eur. J. Immunol. 29, 1667-1675.
35. Naidenko, O. V., Koezuka, Y., Kronenberg, M. (2000) CD1-mediated antigen presentation of glycosphingolipids. Microbes Infect. 2, 621-631.
36. Moody, D. B., Besra, G. S. (2001) Glycolipid targets of CD1-mediated T-cell responses. Immunology 104, 243-251.
37. Zhang, X., Brunner, T., Carter, L., Dutton, R. W., Rogers, P., Bradley, L., Sato, T., Reed, J. C., Green, D., Swain, S. L. (1997) Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185, 1837-1849.
38. Roberts, A. I., Devadas, S., Zhang, X., Zhang, L., Keegan, A., Greeneltch, K., Solomon, J., Wei, L., Das, J., Sun, E., Liu, C., Yuan, Z., Zhou, J. N., Shi, Y. (2003) The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunol. Res. 28, 285-293.
39. Yoshida, S., Fukumoto, S., Kawaguchi, H., Sato, S., Ueda, R., Furukawa, K. (2001) Ganglioside GD2 in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. Cancer Res. 61, 4244-4252.
40. Ladisch, S., Li, R., Olson, E. (1994) Ceramide structure predicts tumor ganglioside immunosuppressive activity. Proc. Natl. Acad. Sci. USA 91, 1974-1978.
41. Kanda, N., Watanabe, S. (2001) Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFNγ production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. J. Immunol. 166, 72-80.