The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 4, 2006, Pages

  Ritzel, R A ^a,b   Veldhuis, J D ^c   Butler, P C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MAYO CLINIC   (United States)

Author keywords

Diabetes mellitus; Entrainment; Islet of Langerhans; Oscillatory glucose; Pulsatile insulin secretion

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; HUMAN CELL; IN VIVO STUDY; INSULIN RELEASE; MASS; NORMAL HUMAN; OSCILLATION; PANCREAS ISLET; PRIORITY JOURNAL; PULSATILE FLOW; BIOLOGICAL RHYTHM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION;

BIOLOGICAL CLOCKS; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS;

EID: 33646111014     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00381.2005     Document Type: Article

References (38)

1. Andersen L, Dinesen B, Jorgensen PN, Poulsen F, and Roder ME. Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 39: 578-582, 1993.
2. Chou HF and Ipp E. Pulsatile insulin secretion in isolated rat islets. Diabetes 39: 112-117, 1990.
3. Crowley WF Jr and McArthur JW. Simulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH). J Clin Endocrinol Metab 51: 173-175, 1980.
4. Davies MJ, Rayman G, Grenfell A, Gray IP, Day JL, and Hales CN. Loss of the first phase insulin response to intravenous glucose in subjects with persistent impaired glucose tolerance. Diabet Med 11: 432-436, 1994.
5. Hansen BC, Jen KC, Belbez Pek S, and Wolfe RA. Rapid oscillations in plasma insulin, glucagon, and glucose in obese and normal weight humans. J Clin Endocrinol Metab 54: 785-792, 1982.
6. Hollingdal M, Juhl CB, Pincus SM, Sturis J, Veldhuis JD, Polonsky KS, Porksen N, and Schmitz O. Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes. Diabetes 49: 1334-1340, 2000.
7. Juhl CB, Hollingdal M, Porksen N, Prange A, Lonnqvist F, and Schmitz O. Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes: evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility. J Clin Endocrinol Metab 88: 3794-3800, 2003.
8. Juhl CB, Porksen N, Hollingdal M, Sturis J, Pincus S, Veldhuis JD, Dejgaard A, and Schmitz O. Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency. Diabetes Care 23: 675-681, 2000.
9. Juhl CB, Porksen N, Pincus SM, Hansen AP, Veldhuis JD, and Schmitz O. Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes. Diabetes 50: 1778-1784, 2001.
10. Juhl CB, Schmitz O, Pincus S, Veldhuis J, and Porksen N. Short-term treatment with GLP-1 increases pulsatile insulin secretion in Type II diabetes with no effect on orderliness. Diabetologia 43: 583-588, 2000.
11. Kjems LL, Kirby BM, Welsh EM, Veldhuis JD, Straume M, McIntyre SS, Yang D, Lefebvre P, and Butler PC. Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig. Diabetes 50: 2001-2012, 2001.
12. Laedtke T, Kjems L, Porksen N, Schmitz O, Veldhuis J, Kao PC, and Butler PC. Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes. Am J Physiol Endocrinol Metab 279: E520-E528, 2000.
13. Lang DA, Matthews DR, Burnett M, and Turner RC. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes 30: 435-439, 1981.
14. Lang DA, Matthews DR, Peto J, and Turner RC. Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N Engl J Med 301: 1023-1027, 1979.
15. Larsen MO, Rolin B, Wilken M, Carr RD, and Gotfredsen CF. Measurements of insulin secretory capacity and glucose tolerance to predict pancreatic beta-cell mass in vivo in the nicotinamide/streptozotocin Gottingen minipig, a model of moderate insulin deficiency and diabetes. Diabetes 52: 118-123, 2003.
16. Lin JM, Fabregat ME, Gomis R, and Bergsten P. Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes. Diabetes 51: 988-993, 2002.
17. Mao CS, Berman N, Roberts K, and Ipp E. Glucose entrainment of high-frequency plasma insulin oscillations in control and type 2 diabetic subjects. Diabetes 48: 714-721, 1999.
18. Marchetti P, Scharp DW, McLear M, Gingerich R, Finke E, Olack B, Swanson C, Giannarelli R, Navalesi R, and Lacy PE. Pulsatile insulin secretion from isolated human pancreatic islets. Diabetes 43: 827-830, 1994.
19. O'Meara NM, Sturis J, Van Cauter E, and Polonsky KS. Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. J Clin Invest 92: 262-271, 1993.
20. Pfeifer MA, Halter JB, Beard JC, and Porte D Jr. Differential effects of tolbutamide on first and second phase insulin secretion in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 53: 1256-1262, 1981.
21. Pfeifer MA, Halter JB, and Porte D Jr. Insulin secretion in diabetes mellitus. Am J Med 70: 579-588, 1981.
22. Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA, and Van Cauter E. Abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus. N Engl J Med 318: 1231-1239, 1988.
23. Porksen N, Grofte B, Nyholm B, Holst JJ, Pincus SM, Veldhuis JD, Schmitz O, and Butler PC. Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion. Diabetes 47: 45-49, 1998.
24. Pørksen N, Grofte T, Greisen J, Mengel A, Juhl C, Veldhuis JD, Schmitz O, Rossle M, and Vilstrup H. Human insulin release processes measured by intraportal sampling. Am J Physiol Endocrinol Metab 282: E695-E702, 2002.
25. Pørksen N, Juhl C, Hollingdal M, Pincus SM, Sturis J, Veldhuis JD, and Schmitz O. Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusions. Am J Physiol Endocrinol Metab 278: E162-E170, 2000.
26. Porksen N, Munn S, Steers J, Veldhuis JD, and Butler PC. Effects of glucose ingestion versus infusion on pulsatile insulin secretion. The incretin effect is achieved by amplification of insulin secretory burst mass. Diabetes 45: 1317-1323, 1996.
27. Pørksen N, Munn S, Steers J, Veldhuis JD, and Butler PC. Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and cluster analysis. Am J Physiol Endocrinol Metab 269: E1106-E1114, 1995.
28. Pørksen N, Nyholm B, Veldhuis JD, Butler PC, and Schmitz O. In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts. Am J Physiol Endocrinol Metab 273: E908-E914, 1997.
29. Pørksen NK, Munn SR, Steers JL, Schmitz O, Veldhuis JD, and Butler PC. Mechanisms of sulfonylurea's stimulation of insulin secretion in vivo: selective amplification of insulin secretory burst mass. Diabetes 45: 1792-1797, 1996.
30. Ritzel R, Schulte M, Porksen N, Nauck MS, Holst JJ, Juhl C, Marz W, Schmitz O, Schmiegel WH, and Nauck MA. Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose tolerance. Diabetes 50: 776-784, 2001.
31. Ritzel RA, Hansen JB, Veldhuis JD, and Butler PC. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab 89: 795-805, 2004.
32. Ritzel RA, Veldhuis JD, and Butler PC. Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: dose-response relationships. J Clin Endocrinol Metab 88: 742-747, 2003.
33. Song SH, Kjems L, Ritzel R, McIntyre SM, Johnson ML, Veldhuis JD, and Butler PC. Pulsatile insulin secretion by human pancreatic islets. J Clin Endocrinol Metab 87: 213-221, 2002.
34. Song SH, McIntyre SS, Shah H, Veldhuis JD, Hayes PC, and Butler PC. Direct measurement of pulsatile insulin secretion from the portal vein in human subjects. J Clin Endocrinol Metab 85: 4491-4499, 2000.
35. Song SH, Rhodes CJ, Veldhuis JD, and Butler PC. Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. Endocrinology 144: 3399-3405, 2003.
36. Sturis J, Van Cauter E, Blackman JD, and Polonsky KS. Entrainment of pulsatile insulin secretion by oscillatory glucose infusion. J Clin Invest 87: 439-445, 1991.
37. Veldhuis JD, Carlson ML, and Johnson ML. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686-7690, 1987.
38. Ward WK, Bolgiano DC, McKnight B, Halter JB, and Porte D Jr. Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Invest 74: 1318-1328, 1984.