Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency

Diabetes Care

Volumn 23, Issue 5, 2000, Pages 675-681

  Juhl, Claus B ^a   PØrksen, Niels ^a   Hollingdal, Malene ^a   Sturis, Jeppe ^b   Pincus, Steven ^d   Veldhuis, Johannes D ^c   Dejgaard, Anders ^b   Schmitz, Ole ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF VIRGINIA   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ORAL ANTIDIABETIC AGENT; REPAGLINIDE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; OSCILLATION; PULSATILE DRUG RELEASE;

EID: 0034077820     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.23.5.675     Document Type: Article

References (34)

1. Lang DA, Matthews DR, Peto J, Turner RC: Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N Engl J Med 301:1023-1027, 1979
2. Goodner CJ, Walike BC, Koerker DJ, Ensinck JW, Brown AC, Chideckel EW, Palmer J, Kalnasy L: Insulin, glucagon and glucose exhibit synchronous, sustained oscillations in fasting monkeys. Science 195: 177-179, 1977
3. Schmitz O, Pedersen SB, Mengel A, Porksen N, Bak J, Moller N, Richelsen B, Alberti KG, Butler PC, Orskov H: Augmented effect of short-term pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects. Metabolism 43:842-846, 1994
4. Matthews DR, Naylor BA, Jones RG, Ward GM, Turner RC: Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Diabetes 32:617-621, 1983
5. Komjati M, Bratusch-Marrain P, Waldhausl W: Superior efficacy of pulsatile versus continuous hormone exposure on hepatic glucose production in vitro. Endocrinology 118: 312-319, 1986
6. Bratusch-Marrain PR, Komjati M, Waldhausl WK: Efficacy of pulsatile versus continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans. Diabetes 35: 922-926, 1986
7. Porksen NK, Munn SR, Steers JL, Schmitz O, Veldhuis JD, Butler PC: Mechanisms of sulfonylureas stimulation of insulin secretion in vivo: selective amplification of insulin secretory burst mass. Diabetes 45: 1792-1797, 1996
8. Porksen N, Munn S, Steers J, Veldhuis JD, Butler PC: Effects of glucose ingestion versus infusion on pulsatile insulin secretion: the incretin effect is achieved by amplification of insulin secretory burst mass. Diabetes 45:1317-1323, 1996
9. Porksen N, Munn SR, Steers JL, Veldhuis JD, Butler PC: Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass. Am J Physiol 270:E1043-E1049, 1996
10. Porksen NK, Grofte T, Nyholm B, Hoist JJ, Pincus SM, Veldhuis JD, Schmitz O, Butler PC: Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion. Diabetes 47:45-44, 1998
11. Schmitz O, Porksen N, Nyholm B, Skjaerback C, Butler PC, Veldhuis JD, Pincus SM: Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM. Am J Physiol 272:E218-E226, 1997
12. Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA, Van Cauter E: Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 318:1231-1239, 1988
13. O'Rahilly S, Turner RC, Matthews DR: Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 318: 1225-1230, 1988
14. Matthews DR, Lang DA, Burnett MA, Turner RC: Control of pulsatile insulin secretion in man. Diabetologia 24:231-237, 1983
15. Andersen L, Dinesen B, Jorgensen PN, Poulsen F, Roder ME: Enzyme inimunoassay for intact human insulin in serum or plasma. Clin Chem 39:578-582, 1993
16. Veldhuis JD, Carlson ML, Johnson ML: The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci U S A 84: 7686-7690, 1987
17. Porksen NK, Nyholm B, Veldhuis JD, Butler PC, Schmitz O: In humans at least 75% of insulin secretion arises from punctuated secretory bursts. Am J Physiol 273:E908-E914, 1997
18. Eaton RP, Allen RC, Schade DS, Erickson KM, Standefer J: Prehepatic insulin production in man: kinetic analysis using peripheral connecting peptide behavior. J Clin Endocrinol Metab 51:520-528, 1980
19. Polonsky KS, Licinio-Paixao J, Given BD, Pugh W, Rue P, Galloway J, Karrison T, Frank B: Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77:98-105, 1986
20. Van Cauter E, Mestrez F, Sturis J, Polonsky KS: Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41:368-377. 1992
21. Pincus SM: Approximate entropy as a measure of system complexity. Proc Natl Acad Sci U S A 88:2297-2301, 1991
22. Pincus SM, Hartman ML, Roelfsema F, Thorner MO, Veldhuis JD: Hormone pulsatility discrimination via coarse and short time-sampling. Am J Physiol 277:E948-957, 1999
23. Owens DR: Repaglinide - prandial glucose regulator: a new class of oral antidiabetic drugs. Diabet Med 15 (Suppl. 4):S28-S36, 1998
24. Fuhlendorff J, Rorsman P, Kofod H, Brand CL, Rolin B, MacKay P, Shymko R, Carr RD: Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes 47:345-351, 1998
25. Tornheim K: Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes 46:1375-1380, 1997
26. 2+ oscillations. Diabete Metab 14:41-45, 1998
27. 2+ in mouse pancreatic β-cells. Diabetes 47:1266-1273, 1998
28. Pincus SM, Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, Veldhuis JD: Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males. Proc Natl Acad Sci U S A 93:14100-14105, 1996
29. Pincus SM, Gevers EF, Robinson IC, van den Berg G, Roelfsema F, Hartman ML, Veldhuis JD: Females secrete growth hormone with more process irregularity than males in both humans and rats. Am J Physiol 270:E107-E115, 1996
30. Veldhuis JD, Metzger DL, Martha PM Jr, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM: Estrogen and testosterone, hut not a nonaromatizable androgen, direct network integration of the hypothalamosomatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab 82:3414-3420, 1997
31. Iranmanesh A, South S, Liem AY, Clemmons D, Thorner MO, Weltman A, Veldhuis JD: Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men. Eur J Endocrinol 139:59-71, 1998
32. Shah N, Evans WS, Bowers CY, Veldhuis JD: Tripartite neuroendocrine activation of the human growth hormone (GH) axis in women by continuous 24-hour GH-releasing peptide infusion: pulsatile, entropic, and nyctohemeral mechanisms. J Clin Endocrinol Metab 84:2140-2150, 1999
33. Diggle PJ: Time Series: A Biostatistical Introduction. Oxford, U.K., Oxford Science, 1990
34. Lang DA, Matthews DR, Burnett M, Turner RC: Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes 30:435-439, 1981