HGF-induced capillary morphogenesis of endothelial cells is regulated by Src

Biochemical and Biophysical Research Communications

Volumn 344, Issue 2, 2006, Pages 617-622

  Kanda, Shigeru ^a   Kanetake, Hiroshi ^b   Miyata, Yasuyoshi ^b  

^a Department of Molecular Microbiology and Immunology   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Capillary morphogenesis; Endothelial cells; Hepatocyte growth factor; PP2; siRNA; Src

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLEEN; UMBILICAL VEIN;

ANIMALS; CAPILLARIES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HEPATOCYTE GROWTH FACTOR; MICE; MORPHOGENESIS; NEOVASCULARIZATION, PHYSIOLOGIC; SRC-FAMILY KINASES;

ANIMALIA; MURINAE;

EID: 33646105863     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.03.183     Document Type: Article

References (31)

1. Bussolino F., Di Renzo M.F., Ziche M., Bocchietto E., Olivero M., Naldini L., Gaudino G., Tamagnone L., Coffer A., and Comoglio P.M. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol. 119 (1992) 629-641
2. Grant D.S., Kleinman H.K., Goldberg I.D., Bhargava M.M., Nickoloff B.J., Kinsella J.L., Polverini P., and Rosen E.M. Scatter factor induces blood vessel formation in vivo. Proc. Natl. Acad. Sci. USA 90 (1993) 1937-1941
3. Sato Y., Okamura K., Morimoto A., Hamanaka R., Hamaguchi K., Shimada T., Ono M., Kohno K., Sakata T., and Kuwano M. Indispensable role of tissue-type plasminogen activator in growth factor-dependent tube formation of human microvascular endothelial cells in vitro. Exp. Cell Res. 204 (1993) 223-229
4. Wang H., and Keiser J.A. Hepatocyte growth factor enhances MMP activity in human endothelial cells. Biochem. Biophys. Res. Commun. 272 (2000) 900-905
5. Lafleur M.A., Handsley M.M., Knauper V., Murphy G., and Edwards D.R. Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs). J. Cell Sci. 115 (2002) 3427-3438
6. Ishizawa K., Kubo H., Yamada M., Kobayashi S., Suzuki T., Mizuno S., Nakamura T., and Sasaki H. Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells. Biochem. Biophys. Res. Commun. 324 (2004) 276-280
7. Camussi G., Montrucchio G., Lupia E., Soldi R., Comoglio P.M., and Bussolino F. Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages. J. Immunol. 158 (1997) 1302-1309
8. Van Belle E., Witzenbichler B., Chen D., Silver M., Chang L., Schwall R., and Isner J.M. Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis. Circulation 97 (1998) 381-390
9. Dong G., Chen Z., Li Z.Y., Yeh N.T., Bancroft C.C., and Van Waes C. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res. 61 (2001) 5911-5918
10. Tomita N., Morishita R., Taniyama Y., Koike H., Aoki M., Shimizu H., Matsumoto K., Nakamura T., Kaneda Y., and Ogihara T. Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, ets-1. Circulation 107 (2003) 1411-1417
11. Zhang Y.W., Su Y., Volpert O.V., and Vande Woude G.F. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc. Natl. Acad. Sci. USA 100 (2003) 12718-12723
12. Nakagami H., Morishita R., Yamamoto K., Taniyama Y., Aoki M., Kim S., Matsumoto K., Nakamura T., Higaki J., and Ogihara T. Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells. J. Hypertens. 18 (2000) 1411-1420
13. Sengupta S., Sellers L.A., Li R.C., Gherardi E., Zhao G., Watson N., Sasisekharan R., and Fan T.P. Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis. Circulation 107 (2003) 2955-2961
14. Kuhlmann C.R., Schaefer C.A., Fehsecke A., Most A.K., Tillmanns H., and Erdogan A. A new signaling mechanism of hepatocyte growth factor-induced endothelial proliferation. J. Thromb. Haemost. 3 (2005) 2089-2095
15. Ishizawar R., and Parsons S.J. c-Src and cooperating partners in human cancer. Cancer Cell 6 (2004) 209-214
16. Summy J.M., and Gallick G.E. Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev. 22 (2003) 337-358
17. Maejima Y., Ueba H., Kuroki M., Yasu T., Hashimoto S., Nabata A., Kobayashi N., Ikeda N., Saito M., and Kawakami M. Src family kinases and nitric oxide production are required for hepatocyte growth factor-stimulated endothelial cell growth. Atherosclerosis 167 (2003) 89-95
18. Yanai N., Satoh T., and Obinata M. Endothelial cells create a hematopoietic inductive microenvironment preferential to erythropoiesis in the mouse spleen. Cell Struct. Funct. 16 (1991) 87-93
19. Kanda S., Landgren E., Ljungstrom M., and Claesson-Welsh L. Fibroblast growth factor receptor 1-induced differentiation of endothelial cell line established from tsA58 large T transgenic mice. Cell Growth Differ. 7 (1996) 383-395
20. Kanda S., Miyata Y., and Kanetake H. Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: possible involvement of c-Akt. J. Biol. Chem. 279 (2004) 4007-4016
21. Tsuda S., Ohtsuru A., Yamashita S., Kanetake H., and Kanda S. Role of c-Fyn in FGF-2-mediated tube-like structure formation by murine brain capillary endothelial cells. Biochem. Biophys. Res. Commun. 290 (2002) 1354-1360
22. Shono T., Kanetake H., and Kanda S. The role of mitogen-activated protein kinase activation within focal adhesions in chemotaxis toward FGF-2 by murine brain capillary endothelial cells. Exp. Cell Res. 264 (2001) 275-283
23. Klint P., Kanda S., Kloog Y., and Claesson-Welsh L. Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation. Oncogene 18 (1999) 3354-3364
24. Kilarski W.W., Jura N., and Gerwins P. Inactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeleton. Exp. Cell Res. 291 (2003) 70-82
25. Mochizuki Y., Nakamura T., Kanetake H., and Kanda S. Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn. J. Cell Sci. 115 (2002) 175-183
26. Eliceiri B.P., Paul R., Schwartzberg P.L., Hood J.D., Leng J., and Cheresh D.A. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell 4 (1999) 915-924
27. Abu-Ghazaleh R., Kabir J., Jia H., Lobo M., and Zachary I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem. J. 360 (2001) 255-264
28. McMullen M., Keller R., Sussman M., and Pumiglia K. Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2. Oncogene 23 (2004) 1275-1282
29. Werdich X.Q., and Penn J.S. Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events. Angiogenesis 9 (2006) 1-12
30. Willett C.G., Boucher Y., di Tomaso E., Duda D.G., Munn L.L., Tong R.T., Chung D.C., Sahani D.V., Kalva S.P., Kozin S.V., Mino M., Cohen K.S., Scadden D.T., Hartford A.C., Fischman A.J., Clark J.W., Ryan D.P., Zhu A.X., Blaszkowsky L.S., Chen H.X., Shellito P.C., Lauwers G.Y., and Jain R.K. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med. 10 (2004) 145-147
31. Casanovas O., Hicklin D.J., Bergers G., and Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8 (2005) 299-309