The expressions of protooncogenes and CYP1A in lungs of rats exposed to sulfur dioxide and benzo(a)pyrene

Regulatory Toxicology and Pharmacology

Volumn 45, Issue 1, 2006, Pages 36-43

  Qin, Guohua ^a   Meng, Ziqiang ^a  

^a SHANXI UNIVERSITY   (China)

Author keywords

Benzo(a)pyrene; c Fos; c Jun; CYP1A1; CYP1A2; Sulfur dioxide

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A; CYTOCHROME P450 1A2; ENZYME; ETHOXYRESORUFIN DEETHYLASE; MESSENGER RNA; METHOXYRESORUFIN O DEMETHYLASE; PROTEIN C FOS; PROTEIN C JUN; SULFUR DIOXIDE; UNCLASSIFIED DRUG;

AIR POLLUTANT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; INHALATION; LUNG; MALE; METABOLIC ACTIVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BASE SEQUENCE; BENZO(A)PYRENE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DRUG SYNERGISM; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION; LUNG; MALE; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, WISTAR; RNA, MESSENGER; SULFUR DIOXIDE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33646104655     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2006.02.006     Document Type: Article

References (46)

1. Amdur M.O. Toxicological appraisal of particulate matter, oxides of sulfur, and sulfuric acid. J. Air Pollut. Control Assoc. 19 (1969) 638-644
2. Amstad P.A., Krupitza G., and Cerutti P.A. Mechanism of c-fos induction by active oxygen. Cancer Res. 52 (1992) 3952-3960
3. Angel P., and Kavim M. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochem. Biophys. Acta 1072 (1991) 129-157
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
5. Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., and Mayer R.T. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450. Biochem. Pharmacol. 34 (1985) 3337-3345
6. Conney A.H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes Memorial Lecture. Cancer Res. 42 (1982) 4875-4917
7. Constantin D., Mehrotra K., Wallin A., Moldeus P., and Jernstrom B. Studies on the effect of sulfite on benzo[a]pyrene-7,8-dihydrodiol activation to reactive intermediates in human polymorphonuclear leukocytes. Chem.-Biol. Interact. 94 (1995) 73-82
8. Ding M., Li J.J., Leonard S.S., Ye J.P., Shi X., Colburn N.H., Castranova V., and Vallyathan V. Vanadate-induced activation of activator protein-1: role of reactive oxygen species. Carcinogenesis 20 (1999) 663-668
9. 6-methlyguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability. Oncogenes 13 (1996) 1927-1935
10. Fouchecourt M.O., and Riviere J.L. Activities of cytochrome P450-dependent monooxygenases and antioxidant enzymes in different organs of Norway rats (Rattus norvegicus) inhabiting reference and contaminated sites. Chemosphere 31 (1995) 4375-4386
11. Green J.L., and Reed G.A. Benzo[a]pyrene bay-region sulfonates, a novel class of reactive intermediates. Chem. Res. Toxicol. 3 (1990) 59-64
12. 2 determination and method sensitivity analysis. J. Environ. Monitor. 3 (2001) 666-670
13. Guengerich F.P. Characterization of roles of human cytochrome P-450 enzymes in carcinogen metabolism. Asia Pac. J. Pharmacol. 5 (1990) 327-345
14. Haider S.S., Hasan M., Hasan S.N., Khan S.R., and Ali S.F. Regional effects of sulfur dioxide exposure on the guinea pig brain lipids, lipid peroxidation and lipase activity. Neurotoxicology 2 (1981) 443-450
15. Herschman H.R. Primary response genes induced by growth factors and tumor promoters. Ann. Rev. Biochem. 60 (1991) 281-319
16. Johnson J.L., Waud W.R., Rajagopalan K.V., Duran M., Beemer F.A., and Wadman S.K. Inborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor. Proc. Nati. Acad. Sci. USA 77 (1980) 3715-3719
17. 3) in vitro. Hum. Exp. Toxicol. 17 (1998) 600-605
18. Landi M.T., Sinha R., Lang N.P., and Kadlubar F.F. Human cytochrome P4501A2. IARC Sci. Publ. 148 (1999) 173-195
19. Leung K.H., Keller D.A., and Menzel D.B. Effect of sulfite on the covalent reaction of benzo[a]pyrene metabolites with DNA. Carcinogenesis 10 (1989) 259-264
20. Mace K., Bowman E.D., Vautravers P., Shields P.G., Harris C.C., and Pfeifer A.M.A. Characterization of xenobiotic-metabolizing enzyme expression in human bronchial mucosa and peripheral lung tissues. Eur. J. Cancer 34 (1998) 914-920
21. Manome Y., Datta R., and Fine H.A. Early response gene induction following DNA damage in astrocytoma cell lines. Biochem. Pharmacol. 45 (1993) 1677-1684
22. Marnett L.J. Peroxyl free radicals: potential mediators of tumour initiation and promotion. Carcinogenesis 8 (1987) 1365-1373
23. McManus M.E., Burgess W.M., Veronese M.E., Huggett A., Quattrochi L.C., and Tukey R.H. Metabolism of 2-acetylamino-fluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res. 50 (1990) 3367-3376
24. Melendez-Colon V.J., Luch A., Seidel A., and Baird W.M. Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites. Carcinogenesis 20 (1999) 1885-1891
25. Meng Z. Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide is a systemic oxidative damage agent. Inhal. Toxicol. 15 (2003) 181-195
26. Meng Z., Qin G., Zhang B., and Bai J. DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice. Mutagenesis 19 (2004) 465-468
27. Meng Z., Qin G., Zhang B., Geng H., Bai Q., Bai W., and Liu C. Oxidative damage of sulfur dioxide inhalation on lungs and hearts of mice. Environ. Res. 93 (2003) 285-292
28. Noji M., Saito M., Nakamura M., Aono M., Saji H., and Saito K. Cysteine synthase overexpression in tobacco confers tolerance to sulfur-containing environmental pollutants. Plant Physiol. 126 (2001) 973-980
29. 2 in Syrian golden hamsters. Exp. Pathol. 28 (1985) 31
30. Pohl R.J., and Fouts J.R. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal. Biochem. 107 (1980) 150-155
31. 2 and NOx on benzo(a)pyrene activating enzymes of the rat liver. Exp. Pathol. 39 (1990) 207-212
32. Qin G., and Meng Z. Effect of sulfur dioxide inhalation on CYP1A1 and CYP1A2 in rat liver and lung. Toxicol. Lett. 160 (2005) 34-42
33. Reddy A.P.M., and Mossmann B.T. Role and regulation of activator protein-1 in toxicant-induced responses of the lung. Am. J. Physiol. Lung Cell Mol. Physiol. 283 (2002) L1161-L1178
34. Reed G.A., Curtis J.F., Mottley C., Eling T.E., and Mason R.P. Epoxidation of (+/-)-7,8-dihydroxy- 7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen. Proc. Natl. Acad. Sci. USA 83 (1986) 7499-7502
35. Reed G.A. Sulfite-dependent mutagenicity of benzo[a]pyrene derivatives. Carcinogenesis 8 (1987) 1145-1148
36. Samukawa T., Arasidani K., Hori H., Hirano H., and Arima T. c-jun mRNA expression and profilin mRNA amplification in rat alveolar macrophages exposed to volcanic ash and sulfur dioxide. Ind. Health 41 (2003) 313-319
37. Shapiro R. Genetic effects of bisulfite (sulfur dioxide). Mutat. Res. 38 (1977) 149-176
38. Shimada T., Yamazaki H., Mimura M., Wakamiya N., Ueng W.-F., Guengerich F.P., and Inui Y. Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human and fetal livers and adult lungs. Drug Metab. Dispos. 24 (1996) 515-552
39. Smeyne R.J., Verndrell M., Hayward M., Baker S.J., Miae G.G., Schilling K., Curran T., and Mergan J.I. Continuous c-fos expression proceeds programmed cell death in vivo. Nature 363 (1993) 166-169
40. Smith T.J., Guo Z., Guengerich F.P., and Yang C.S. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate. Carcinogenesis 17 (1996) 809-813
41. Wei C., Caccavale R.J., Kehoe J.J., Thomas P.E., and Iba M.M. CYP1A2 is expressed along with CYP1A1 in the human lung. Cancer Lett. 171 (2001) 113-120
42. Whitlock Jr. J.P. Induction of cytochrome P4501A1. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 103-125
43. Yamada K., Suzuki T., Kohara A., Hayashi M., Hakura A., Mizutani T., and Saeki K. Effect of 10-aza-substitution on benzo[a]pyrene mutagenicity in vivo and in vitro. Mutat. Res. 521 (2002) 187-200
44. Yargicoglu P., Agar A., Gumusluoriob S., Bilmen S., and Oguz Y. Age-related alterations in antioxidant enzymes, lipid peroxide levels, and somatosensoru-evoked potentials: effect of sulfur dioxide. Arch. Environ. Contam. Toxicol. 37 (1999) 554-560
45. Zaher H., Yang T.J., Gelboin H.V., Fernandez-Salguero P., and Gonzalez F.J. Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse. Biochem. Pharmacol. 55 (1998) 235-238
46. Zhao W., and Ramos K.S. Cytotoxic response profiles of cultured rat hepatocytes to selected aromatic hydrocarbons. Toxicol. In Vitro 12 (1998) 175-182