Polymorphisms in the gene encoding hepatocyte nuclear factor-4δ and susceptibility to type 2 diabetes in a Polish population

Diabetes and Metabolism

Volumn 32, Issue 1, 2006, Pages 86-88

  Wanic, K ^a,b   Malecki, M T ^a   Wolkow, P P ^b   Klupa, T ^a   Skupien, J ^a   Bobrek, J ^a   Kozek, E ^a   Krolewski, A S ^b   Sieradzki, J ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Diabetes; Gene; HNF 4 ; Polymorphism

Indexed keywords

GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTE NUCLEAR FACTOR 4 DELTA; INSULIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; HNF4A PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CODE; GENETIC EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HAPLOTYPE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; QUANTITATIVE TRAIT LOCUS; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; BODY MASS; DISEASE PREDISPOSITION; GENETICS; MIDDLE AGED; POLAND; REFERENCE VALUE;

BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DISEASE SUSCEPTIBILITY; FEMALE; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MIDDLE AGED; POLAND; POLYMORPHISM, GENETIC; PREDIABETIC STATE; REFERENCE VALUES;

EID: 33646083250     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1262-3636(07)70252-5     Document Type: Article

References (14)

1. JI L, Malecki M, Warram JH, et al. New susceptibility locus for NIDDM is localized to human chromosome 20q. Diabetes 1997;46:876-81
2. Bowden DW, Sale M, Howard TD, et al. Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy. Diabetes 1997;46:882-6
3. Zouali H, Hani EH, Philippi A, et al. A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. Hum Mol Genet 1997;6:1401-8
4. Love-Gregory LD, Wasson J, Ma J, et al. A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi Jewish population. Diabetes 2004;53:1134-40
5. Silander K, Mohlke KL, Scott LJ, et al. Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes 2004;53:1141-9
6. Weedon MN, Owen KR, Shields B, et al. Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population. Diabetes 2004;53:3002-6
7. Winckler W, Graham RR, de Bakker PI, et al. Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people. Diabetes 2005;54:886-92
8. Vaxillaire M, Dina C, Lobbens S, et al. Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population. Diabetologia 2005;48:440-4
9. Yamagata K, Furuta H, Oda N, et al. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 1996;384:458-60
10. Thomas H, Jaschkowitz K, Bulman M, et al. A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young. Hum Mol Genet 2001;10:2089-97
11. Malecki MT, Frey J, Klupa T, et al. The Pro12Ala polymorphism of PPARgamma2 gene and susceptibility to type 2 diabetes mellitus in a Polish population. Diabetes Res Clin Pract 2003;62:105-1
12. Chen X, Levine L, Kwok P-Y. Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res 1999;9:492-8
13. Hsu TM, Chen X, Duan S, et al. Universal SNP genotyping assay with fluorescence polarization detection. BioTechniques 2001;31:560-70
14. Ambrosius WT, Lange EM, Langefeld CD. Power for genetic association studies with random allele frequencies and genotype distributions. Am J Hum Genet 2004;74:683-69