Synthesis and in vivo biodistribution of F-18 labeled 3-cis-, 3-trans-, 4-cis-, and 4-trans-fluorocyclohexane derivatives of WAY 100635

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3737-3748

  Lang, Lixin ^a   Jagoda, Elaine ^a   Ma, Ying ^a   Sassaman, Mark B ^a   Eckelman, William C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

5 HT1A receptors; Fluorine 18; In vitro metabolites; WAY 100635

Indexed keywords

3 FLUORO N [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 FLUORO N [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMIDE; CARBOXYLIC ACID DERIVATIVE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PENTAMETHYLBENZYL 3 (METHANESULFONYL)OXYCYCLOHEXANECARBOXYLATE; PENTAMETHYLBENZYL 3 FLUOROXYCYCLOHEXANECARBOXYLATE; PENTAMETHYLBENZYL 3 HYDROXYCYCLOHEXANECARBOXYLATE; PENTAMETHYLBENZYL 4 (NITROBENZENESULFONYL)OXYCYCLOHEXANECARBOXYLATE; PENTAMETHYLBENZYL 4 FLUOROCYCLOHEXANECARBOXYLATE; PENTAMETHYLBENZYL 4 HYDROXYCYCLOHEXANECARBOXYLATE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CEREBELLUM; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DEFLUORINATION; DRUG SYNTHESIS; EVALUATION; HALF LIFE TIME; HIPPOCAMPUS; LIGAND BINDING; LIQUID CHROMATOGRAPHY; LIVER CELL; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; CELL LINE; CELLS, CULTURED; CYCLOHEXANES; DRUG EVALUATION, PRECLINICAL; FLUORINE RADIOISOTOPES; HEPATOCYTES; HUMANS; LIGANDS; MALE; MOLECULAR STRUCTURE; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 33646057984     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.064     Document Type: Article

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