Naturally developing memory T cell xenoreactivity to swine antigens in human peripheral blood lymphocytes

Journal of Immunology

Volumn 164, Issue 5, 2000, Pages 2790-2796

  Hartig, Carsten V ^a   Haller, Gary W ^b   Sachs, David H ^b   Kuhlenschmidt, Shannon ^a   Heeger, Peter S ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Louis Stokes Cleveland Veterans Administration   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGENICITY; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; FOOD INTAKE; HUMAN; HUMAN CELL; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SWINE; T LYMPHOCYTE SUBPOPULATION; XENOTRANSPLANTATION;

EID: 0034161781     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.5.2790     Document Type: Article

References (28)

1. Auchincloss, Jr., H., and D. Sachs. 1998. Xenotransplanlation. Annu. Rev. Immunol. 16:433.
2. Platt, J., R. Fischel, A. Matas, S. Reif, R. Bolman, and F. Bach. 1991. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 52:214.
3. Oriol, R., Y. Ye, E. Koren, and D. Cooper. 1993. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 56: 1433.
4. Platt, J., B. Lindman, R. Geller, H. Noreen, J. Swanson, A. Dalmasso, and F. Bach. 1991. The role of natural antibodies in the activation of xenogeneic endothelial cells. Transplantation 52:1037.
5. Sandrin, M., H. Vaughan, and I. McKenzie. 1994. Identification of Ga1 (α1,3) Ga1 as the major epitope for pig-to-human vascularized xenografts. Transplant. Rev. 8:134.
6. Kearns-Jonker, M., D. Cramer, L. Dane, J. Swensson, and L. Makowka. 1997. Human serum reactivity to porcine endothelial cells after antisense-mediated down-regulation of GpIIIa expression. Transplantation 63:588.
7. Byrne, G., K. McCurry, M. Martin, S. McClellan, J. Platt, and J. Logan. 1997. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 63:149.
8. Dalmasso, A., G. Vercellotti, J. Platt, and F. Bach. 1991. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Transplantation 52:530.
9. Rydberg, L., E. Hallberg, S. Bjorck, S. Magnusson, V. Strokan, B. Samuelsson, and M. Breimer. 1995. Studies on the removal of anti-pig xenoantibodies in the human by plasmapheresis/immunoadsorption. Xenotransplantation 2:253.
10. Taniguchi, S., F. Neethling, E. Korchagina, N. Bovin, Y. Ye, T. Kobayashi, M. Niekrasz, S. Li, E. Koren, R. Oriol, and D. Cooper. 1996. In vivo immuno-adsorption of antipig antibodies in baboons using a specific Ga1(α1-3)Ga1 column. Transplantation 62:1379.
11. Sandrin, M., W. Fodor, E. Mouhtouris, N. Osman, S. Cohney, S. Rollins, E. Guilmette, E. Setter, S. Squinto, and I. McKenzie. 1995. Enzymatic remodeling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nat. Med. 1:1261.
12. + T cells mediate rejection of porcine xenografts. J. Immunol. 162:5256.
13. Yamada, K., D. Sachs, and H. DerSimonian. 1995. Human anti-porcine xenogeneic T cell response: evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J. Immunol. 155:5249.
14. + helper T cells and self antigen-presenting cells in the mouse. J. Exp. Med. 172:567.
15. Korsgren, O. 1997. Acute cellular xenograft rejection. Xenotransplantation 4:11.
16. Heeger, P., N. Greenspan, S. Kuhlenschmidt, C. Dejelo, D. Hricik, J. Shulak, and M. Tary-Lehmann. 1999. Pretransplant frequency of donor-specific IFN-γ-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J. Immunol. 163:2267.
17. Benichou, G., A. Valujskikh, and P. Heeger. 1999. Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice. J. Immunol. 162: 352.
18. Lechler, R., T. Heaton, L. Barber, V. Bal, J. Batchelor, and G. Lombardi. 1992. Molecular mimicry by major histocompatibility complex molecules and peptides accounts for some alloresponses. Immunol. Lett. 34:63.
19. Lombardi, G., S. Sidhu, M. Daly, J. Batchelor, W. Makgoba, and R. Lechler. 1990. Are primary alloresponses truly primary? Int. Immunol. 2:9.
20. + T cells. J. Exp. Med. 170:991.
21. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined T cell receptor number and tunable thresholds. Science 273:104.
22. + T cells are hyperactive to antigenic challenge in vitro. J. Exp. Med. 184:2141.
23. -) to TCR/CD8 signaling in response to antigen. J. Immunol. 160:3236.
24. Murray, A. G., M. M. Khodadoust, J. S. Pober, and A. L. Bothwell. 1994. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1:57.
25. Wren, S., S. Wang, N. Thai, B. Conrad, R. Hoffman, J. Fung, R. Simmons, and S. Ildstad. 1993. Evidence for early Th2 T cell predominance in xenoreactivity. Transplantation 56:905.
26. Alter, B. J., and F. H. Bach. 1990. Cellular basis of the proliferative response of human T cells to mouse xenoantigens. J. Exp. Med. 171:333.
27. Owen, R. 1977. Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study. Gastroenterology 72:440.
28. Neutra, M., T. Phillips, E. Mayer, and D. Fishkind. 1987. Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch. Cell Tissue Res. 247:537.