Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro

Diabetes

Volumn 48, Issue 9, 1999, Pages 1713-1719

  Murray, Allan G ^a   Nelson, Randy C ^a   Rayat, Gina R ^a   Elliott, John F ^a   Korbutt, Gregory S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CELL ADHESION MOLECULE; CONCANAMYCIN A; CYTOKINE; LECTIN; LEUKOCYTE ANTIGEN; PERFORIN;

ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DIABETES MELLITUS; HELPER CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; NEWBORN; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SPLEEN CELL; SUPPRESSOR CELL; SWINE; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, NEWBORN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; COCULTURE TECHNIQUES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; IMMUNITY, CELLULAR; ISLETS OF LANGERHANS; KILLER CELLS, NATURAL; SWINE; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 0032878573     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.9.1713     Document Type: Article

References (41)

1. Groth CG, Andersson A, Korsgren O, Tibell A, Tollemar J, Kumagai-Braesch M, Moller E, Bolinder J, Ostman J, Bjoersdorff A, Hellerstrom C: Transplantation of porcine fetal islet-like cell clusters into eight diabetic patients. Transplant Proc 25:970, 1993
2. Sun Y, Ma X, Zhou D, Vacek I, Sun AM: Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J Clin Invest 98:1417-1422, 1996
3. Korbutt GS, Elliott JF, Ao Z, Smith DK, Warnock GL, Rajotte RV: Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest 97:2119-2129, 1996
4. Lawson JH, Platt JL: Molecular barriers to xenotransplantation. Transplantation 62:303-310, 1996
5. Korbutt GS, Aspeslet L, Ao Z, Warnock GL, Ezekowitz J, Koshal A, Rajotte RV, Yatscoff RW: Porcine islet cell antigens are recognized by xenoreactive natural human antibodies of both IgG and IgM subtypes. Transplant Proc 28:837-838, 1996
6. Shiroki R, Naziruddin B, Shishido S, Duffy BF, Howard T, Mohanakumar T: Human peripheral blood leukocyte-reconstituted severe combined immunodeficient mouse: analysis of the human immune response against porcine islet transplantation. Transplantation 63:818-823, 1997
7. McCurry KR, Kooyman DL, Alvarado CG, Cotterell AH, Martin MJ, Logan JS, Platt JL: Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1:423-427, 1995
8. Kroshus TJ, Bolman RM III, Dalmasso AP, Rollins SA, Guilmette ER, Williams BL, Squinto SP, Fodor WL: Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model. Transplantation 61:1513-1521, 1996
9. Leventhal JR, Matas AJ, Sun LH, Reif S, Bolman RM 3d, Dalmasso AP, Platt JL: The immunopathology of cardiac xenograft rejection in the guinea pig-torat model. Transplantation 56:1-8, 1993
10. Murray AG, Khodadoust MM, Pober JS, Bothwell AL: Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1:57-63, 1994
11. Bravery CA, Batten P, Yacoub MH, Rose ML: Direct recognition of SLA- and HLA-like class II antigens on porcine endothelium by human T cells results in T cell activation and release of interleukin-2. Transplantation 60:1024-1033, 1995
12. Rollins SA, Kennedy SP, Chodera AJ, Elliott EA, Zavoico GB, Matis LA: Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and cosumulation by porcine ligands for LFA-1 and CD2. Transplantation 57:1709-1716, 1994
13. Lucas PJ, Shearer GM, Neudorf S, Gress RE: The human antimurine xenogeneic cytotoxic response. I. Dependence on responder antigen presenting cells. J Immunol. 144:4548-4554, 1990
14. Kirk AD, Li RA, Kinch MS, Abernethy KA, Doyle C, Bollinger RR: The human antiporcine cellular repertoire: in vitro studies of acquired and innate cellular responsiveness. Transplantation 55:924-931, 1993
15. Yamada K, DerSimonian H, Sachs DH: The mechanism of xenogeneic cell-mediated lympholysis between human and pig cells. Transplant Proc 28:757, 1996
16. Donnelly CE, Yatko C, Johnson EW, Edge AS: Human natural killer cells account for non-MHC class I-restricted cytolysis of porcine cells. Cell Immunol 175:171-178, 1997
17. Collins T, Krensky AM, Clayberger C, Fiers W, Gimbrone MA, Burakoff SJ, Pober JS: Human cytolytic T lymphocyte interactions with vascular endothelium and flbroblasts: role of effector and target cell molecules. J Immunol 133:1878-1884, 1984
18. Kataoka T, Takaku K, Magae J, Shinohara N, Takayama H, Kondo S, Nagai K: Acidification is essential for maintaining the structure and function of lytic granules in CTL. J Immunol 153:3938-3947, 1994
19. McCurry KR, Kooyman DL, Diamond LE, Byrne GW, Martin MJ, Logan JS, Platt JL: Human complement regulatory proteins in transgenic animals regulate complement activation in xenoperfused organs. Transplant Proc 27:317-318, 1995
20. Benda B, Karlsson-Parra A, Ridderstad A, Korsgren O: Xenograft rejection of porcine islet-like cell clusters in immunoglobulin-or Fc-receptor gamma-deficient mice. Transplantation 62:1207-1211, 1996
21. Karlsson-Parra A, Ridderstad A, Wallgren AC, Moller E, Ljunggren HG, Korsgren O: Xenograft rejection of porcine islet-like cell clusters in normal and natural killer cell-depleted mice. Transplantation 61:1313-1320, 1996
22. Heiser A, Ulrichs K, Eckstein V, Muller-Ruchholtz W: Xenogeneic cellular response of human lymphocytes to porcine lymphocytes and isolated porcine pancreatic islets. Transplant Proc 24:2881-2882, 1992
23. Knospe S, Kohler E, Kloting I: Cell-mediated immune reactions against islets of Langerhans in diabetes-prone BB rats. Exp Clin Endocrinol 89:290-296, 1987
24. Stock PG, Ascher NL, Platt JL, Kaufman DB, Chen S, Field MJ, Sutherland DER: Effect of immunodeplen'on of MHC class II-positive cells from pancreatic islets on generation of cytotoxic T-lymphocytes in mixed islet-lymphocyte coculture. Diabetes 38 (Suppl. 1):157-160, 1989
25. Nagata M, Yokono K, Hayakawa M, Kawase Y, Hatamori N, Ogawa W, Yonezawa K, Shii K, Baba S: Destruction of pancreatic islet cells by cytotoxic T lymphocytes in nonobese diabetic mice. J Immunol 143:1155-1162, 1989
26. Nakamura N, Woda BA, Tafuri A, Greiner DL, Reynolds CW, Ortaldo J, Chick W, Handler ES, Mordes JP, Rossini AA: Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro. Diabetes 39:836-843, 1990
27. Hayakawa M, Yokono K, Nagata M, Hatamori N, Ogawa W, Miki A, Mizoguti H, Baba S: Morphological analysis of selective destruction of pancreatic β-cells by cytotoxic T lymphocytes in NOD mice. Diabetes 40:1210-1217, 1991
28. Nagata M, Santamaria P, Kawamura T, Utsugi T, Yoon JW: Evidence for the role of CDS+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice. J Immunol 152:2042-2050, 1994
29. Yoneda R, Yokono K, Nagata M, Tominaga Y, Moriyama H, Tsukamoto K, Miki M, Okamoto N, Yasuda H, Amano K, Kasuga M: CDS cytotoxic T-cell clone rapidly transfers autoimmune diabetes in very young NOD and MHC class I-compatible scid mice. Diabetologia 40:1044-1052, 1997
30. Kagi D, Odermatt B, Ohashi PS, Zinkemagel RM, Hengartner H: Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity. J Exp Med 183:2143-2152, 1996
31. Kagi D, Odermatt B, Seiler P, Zinkemagel RM, Mak TW, Hengartner H: Reduced incidence and delayed onset of diabetes in perforin-deflcient nonobese diabetic mice. J Exp Med 186:989-997, 1997
32. Inverardi L, Clissi B, Stolzer AL, Bender JR, Sandri MS, Pardi R: Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues. Transplantation 63:1318-1330, 1997
33. Goodman DJ, Von Albertini M, Wilson A, Millan MT, Bach FH: Direct activation of porcine endothelial cells by human natural killer cells. Transplantation 61:763-771, 1996
34. Malyguine AM, Saadi S, Platt JL, Dawson JR: Human natural killer cells induce morphologic changes in porcine endothelial cell monolayers. Transplantation 61:161-164, 1996
35. Shishido S, Naziruddin B, Howard T, Mohanakumar T: Recognition of porcine major histocompatibility complex antigens by human CDS+ cytolytic T cell clones. Transplantation 64:340-346, 1997
36. Lanier LL: Natural killer cells: from no receptors to too many. Immunity 6:371-378, 1997
37. Rollins SA, Evans MJ, Johnson KK, Elliot EA, Squinto SP, Matis LA, Rother RP: Molecular and functional analysis of porcine E-selectin reveals a potential role in xenograft rejection. Biochem Biophys Res Commun 204:763-771, 1994
38. Lalain S, Chailous L, Gouin E, Sai P: Intensity and mechanisms of in vitro xenorecognition of adult pig pancreatic islet cells by CD4+ and CDS+ lymphocytes from type I diabetic or healthy subjects. Diabetologia 42:330-335, 1999
39. Sullivan JA, Oettinger HF, Sachs DH, Edge ASB: Analysis of polymorphism in porcine MHC class I genes. J Immunol 159:2318-2326, 1997
40. Storkus WJ, Dawson JR: Target structures involved in natural killing (NK): characteristics, distribution, and candidate molecules. Crit Rev Immunol 10:393-416, 1991
41. Yagi N, Yokono K, Amano K, Nagata M, Tsukamoto K, Hasegawa Y, Yoneda R, Okamoto N, Moriyama H, Miki M, Tominaga Y, Miyazaki J-i, Yagita H, Okumura K, Mizoguchi A, Miki A, Ide C, Maeda S, Kasuga M: Expression of intercellular adhesion molecule 1 on pancreatic β-cells accelerates β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes. Diabetes 44:744-752, 1995