Ezetimib influences the expression of raft-associated antigens in human monocytes

Cytometry Part A

Volumn 69, Issue 3, 2006, Pages 206-208

  Orsó, Evelyn ^a   Werner, Tobias ^a   Wolf, Zsuzsanna ^a   Bandulik, Sascha ^a   Kramer, Werner ^b   Schmitz, Gerd ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

CD13; Detergent resistant microdomain; Ezetimib

Indexed keywords

CD11B ANTIGEN; CD14 ANTIGEN; CD16 ANTIGEN; CD36 ANTIGEN; CD64 ANTIGEN; EZETIMIBE; MICROSOMAL AMINOPEPTIDASE;

ARTICLE; CELL FUNCTION; CELL MEMBRANE; CELLULAR DISTRIBUTION; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOBLOTTING; IN VITRO STUDY; MACROPHAGE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTICHOLESTEREMIC AGENTS; ANTIGENS, CD; ANTIGENS, CD11B; ANTIGENS, CD13; ANTIGENS, CD14; ANTIGENS, CD36; ANTIGENS, SURFACE; AZETIDINES; CELL DIFFERENTIATION; CELL MEMBRANE; FLOW CYTOMETRY; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MEMBRANE MICRODOMAINS; MICROSCOPY, FLUORESCENCE; MONOCYTES; PROTEIN TRANSPORT; RECEPTORS, IGG;

EID: 33645912053     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.20229     Document Type: Article

References (6)

1. Olsen J, Kokholm K, Noren O, Sjöstrom H. Structure and expression of aminopeptidase N. Adv Exp Med Biol 1997;421:47-57.
2. Navarrete Santos A, Roentsch J, Danielsen EM, Langer J, Riemann D. Aminopeptidase N/CD13 is associated with raft membrane microdomains in monocytes. Biochem Biophys Res Commun 2000;269:143-148.
3. Mina-Osorio P, Ortega E. Aminopeptidase N (CD13) functionally interacts with FcγRs in human monocytes. J Leukoc Biol 2005;77:1008-1017.
4. Kramer W, Girbig F, Corsiero D, Pfenninger A, Frick W, Jähne G, Rhein M, Wendler W, Lottspeich F, Hochleitner EO, Orsó E, Schmitz G. Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor Ezetimibe in the enterocyte brush border membrane. J Biol Chem 2005;280:1306-1320.
5. Pfeiffer A, Boettcher A, Orsó E, Kapinsky M, Nagy P, Bodnár A, Spreitzer I, Liebisch G, Drobnik W, Gempel K, Horn M, Holmer S, Hartung T, Multhoff G, Schütz G, Schindler H, Ulmer AJ, Heine H, Stelter F, Schütt C, Rothe G, Szölldosi J, Damjanovich S, Schmitz G. Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur J Immunol 2001;31:3153-3164.
6. Drobnik W, Borsukova H, Boettcher A, Pfeiffer A, Liebisch G, Schütz GJ, Schindler H, Schmitz G. Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains. Traffic 2002;3:268-278.