Prediction oriented QSAR modelling of EGFR inhibition

Current Medicinal Chemistry

Volumn 13, Issue 3, 2006, Pages 277-287

  Szantai Kis C ^a,c   Kovesdi I ^b,c   Eros, D ^c   Banhegyi P ^a   Ullrich, A ^d   Keri G ^a,c   Orfi, L ^a,c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b EGIS PHARMACEUTICALS LTD   (Hungary)

^c Vichem Chemie Ltd   (Hungary)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Diverse compound set; EGFR inhibitors; External validation; Prediction oriented QSAR; Repeated trainings evaluations; Virtual screening

Indexed keywords

ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; ENZYME INHIBITOR;

AUTOMATION; BINDING SITE; CANCER RESEARCH; CANCER SURVIVAL; DRUG EFFICACY; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; GENETIC ALGORITHM; HUMAN; LUNG NON SMALL CELL CANCER; PREDICTION; PROTEIN BINDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SCORING SYSTEM; STATISTICAL ANALYSIS; STRUCTURE ANALYSIS; VALIDATION PROCESS; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM;

ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 33645848953     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706775476098     Document Type: Review

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