Lateral parabrachial lesions disrupt paraoxon-induced conditioned flavor avoidance

Toxicological Sciences

Volumn 91, Issue 1, 2006, Pages 210-217

  López Grancha, Matilde ^a   Sánchez Amate, Carmen ^a   Navarro, Montserrat ^b   Carvajal, Francisca ^a   Sánchez Santed, Fernando ^a   Cubero, Inmaculada ^a  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Associative sickness properties; Conditioned flavor aversion; Lateral parabrachial area; Organophosphates; Paraoxon

Indexed keywords

CHOLINESTERASE; ORGANOPHOSPHATE; PARAOXON; PARATHION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN DAMAGE; CHOLINERGIC TRANSMISSION; CLINICAL FEATURE; CONDITIONING; CONTROLLED STUDY; GUSTATORY SYSTEM; HYPERACTIVITY; HYPOTHERMIA; HYPOTHESIS; JAW MOVEMENT; METABOLITE; MULTIPLE CHEMICAL SENSITIVITY; NERVOUS SYSTEM FUNCTION; NONHUMAN; OLFACTORY SYSTEM; PARABRACHIAL NUCLEUS; PROTEIN TARGETING; RAT; SENSORY STIMULATION; TASTE AVERSION;

ANIMALS; AVOIDANCE LEARNING; BODY TEMPERATURE; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CONDITIONING, CLASSICAL; MALE; PARAOXON; RATS; RATS, WISTAR; TASTE;

ANIMALIA;

EID: 33645827328     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj126     Document Type: Article

References (39)

1. Bernstein, I. L., Chavez, M., Allen, D., and Taylor, E.M. (1992). Area postrema mediation of physiological and behavioral effects of lithium chloride in the rat. Brain Res. 575, 132-137.
2. Bignami, G., Giardini, V., and Scorrano, M. (1985). Behaviorally augmented versus other components in organophosphate tolerance: The role of reinforcement and response factors. Fundam. Appl. Toxicol. 5, S213-S224.
3. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
4. Bures, J., Bermudez-Rattoni, F., and Yamamoto, T. (1998). Conditioned Taste Aversion: Memory of a Special Kind. Oxford University Press, Oxford.
5. Carvajal, F., Sanchez-Amate, M. C., Sanchez-Santed, F., and Cubero, I. (2005). Neuroanatomical targets of the organophosphate chlorpyrifos by c-fos immunolabeling. Toxicol. Sci. 84, 360-367.
6. Casida, J. E., and Quistad, G. B. (2004). Organophosphate toxicology: Safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17, 983-998.
7. Cubero, I., Lopez, M., Navarro, M., and Puerto, A. (2001). Lateral parabrachial lesions impair taste aversion learning induced by blood-borne visceral stimuli. Pharmacol. Biochem. Behav. 69, 157-163.
8. Cubero, I., and Puerto, A. (2000). Lateral parabrachial lesions impair intraperitoneal but not intraventricular methylscopolamine-induced taste aversion learning. Brain Res. 871, 113-119.
9. Devriese, S., Winters, W., Stegen, K., Van Diest, I., Veulemans, H., Nemery, B., Eelen, P., Van de Woestijne, K., and Van den Bergh, O. (2000). Generalization of acquired somatic symptoms in response to odors: A Pavlovian perspective on multiple chemical sensitivity. Psychosom. Med. 62, 751-759.
10. Ellman, G. L., Courtney, K. D., Andres, V., Jr., and Feather-Stone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88-95.
11. Ferguson, E., and Cassaday, H. J. (1999). The Gulf War and illness by association. Br. J. Psychol. 90(Pt. 4), 459-475.
12. Ferguson, E., and Cassaday, H. J. (2001). Theoretical accounts of Gulf War syndrome: From environmental toxics to psychoneuroimmunology and neurodegeneration. Behav. Neurol. 13, 133-147.
13. Ferguson, E., Cassaday, H. J., and Bibby, P. A. (2004). Odors and sounds as triggers for medically unexplained symptoms: A fixed-occasion diary study of Gulf War veterans. Ann. Behav. Med. 27, 205-214.
14. Gordon, C. J., and Rowsey, P. J. (1999). Are circulating cytokines interleukin-6 and tumor necrosis factor alpha involved in chlorpyrifos-induced fever? Toxicology 134, 9-17.
15. Gupta, R. C. (2004). Brain regional heterogeneity and toxicological mechanism of organophosphates and carbamates. Toxicol. Mech. Methods 14, 103-143.
16. Henderson, R. F., Barr, E. B., Blackwell, W. B., Clark, C. R., Conn, C. A., Kalra, R., March, T. H., Sopori, M. L., Tesfaigzi, Y., Menache, M. G., et al. (2002). Response of rats to low levels of sarin. Toxicol. Appl. Pharmacol. 184, 67-76.
17. Konsman, J. P., Parnet, P., and Dantzer, R. (2002). Cytokine-induced sickness behaviour: Mechanisms and implications. Trends Neurosci. 25, 154-159.
18. McDaniel, K. L., and Moser, V. C. (1993). Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin. Neurotoxicol. Teratol. 15, 71-83.
19. Mediavilla, C., Molina, F., and Puerto, A. (2005). Concurrent conditioned taste aversion: A learning mechanism based on rapid neural versus flexible humoral processing of visceral noxious substances. Neurosci. Biobehav. Rev. 29, 107-118.
20. Miller, C. S. (2000). Toxicant-induced loss of tolerance. Addiction 96, 115-139.
21. Moser, V. C. (1995). Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats. Neurotoxicol. Teratol. 17, 617-625.
22. Navarro, M., and Cubero, I. (2003). Lateral parabrachial lesions impair lithium chloride-induced aversive responses but not saccharin-induced flavor preference. Brain Res. 990, 195-202.
23. Overstreet, D. H., and Djuric, V. (1999). Links between multiple chemical sensitivity and asthma in a rat model of cholinergic hypersensitivity: A brief review. Toxicol. Ind. Health 15, 517-521.
24. Paxinos, G., and Watson, C. (1986). The Rat Brain Stereotaxic Coordinates, 2nd ed., Academic Press, San Diego.
25. Pope, C. N. (1999). Organophosphorus pesticides: Do they all have the same mechanism of toxicity? J. Toxicol. Environ. Health B Crit. Rev. 2, 161-181.
26. Reilly, S. (1999). The parabrachial nucleus and conditioned taste aversion. Brain Res. Bull. 48, 239-254.
27. Reilly, S., and Trifunovic, R. (2001). Lateral parabrachial nucleus lesions in the rat: Neophobia and conditioned taste aversion. Brain Res. Bull. 55, 359-366.
28. Roney, P. L., Jr., Costa, L. G., and Murphy, S. D. (1986). Conditioned taste aversion induced by organophosphate compounds in rats. Pharmacol. Biochem. Behav. 24, 737-742.
29. Rowsey, P. J., and Gordon, C. J. (1999). Tumor necrosis factor is involved in chlorpyrifos-induced changes in core temperature in the female rat. Toxicol. Lett. 109, 51-59.
30. Sakai, N., and Yamamoto, T. (1999). Possible routes of visceral information in the rat brain in formation of conditioned taste aversion. Neurosci. Res. 35, 53-61.
31. Saleh, T. M., and Cechetto, D. F. (1995). Neurochemical interactions in the parabrachial nucleus mediating visceral inputs to visceral thalamic neurons. Am. J. Physiol. 268(3 Pt. 2), R786-R795.
32. Saper, C. B. (2002). The central autonomic nervous system: Conscious visceral perception and autonomic pattern generation. Annu. Rev. Neurosci. 25, 433-469.
33. Siegel, S. (1999). Multiple chemical sensitivity as a conditional response. Toxicol. Ind. Health 15, 323-330.
34. Svensson, I., Waara, L., Johansson, L., Bucht, A., and Cassel, G. (2001). Soman-induced interleukin-1 beta mRNA and protein in rat brain. Neurotoxicology 22, 355-362.
35. Thiele, T. E., Marsh, D. J., Ste Marie, L., Bernstein, I. L., and Palmiter, R. D. (1998). Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature 396, 366-369.
36. Van den Bergh, O., Devriese, S., Winters, W., Veulemans, H., Nemery, B., Eelen, P., and Van de Woestijne, K. P. (2001). Acquiring symptoms in response to odors: A learning perspective on multiple chemical sensitivity. Ann. N. Y. Acad. Sci. 933, 278-290.
37. Winters, W., Devriese, S., Eelen, P., Veulemans, H., Nemery, B., and Van den Bergh, O. (2001). Symptom learning in response to odors in a single odor respiratory learning paradigm. Ann. N. Y. Acad. Sci. 933, 315-318.
38. Winters, W., Devriese, S., Van Diest, I., Nemery, B., Veulemans, H., Eelen, P., Van de Woestijne, K., and Van den Bergh, O. (2003). Media warnings about environmental pollution facilitate the acquisition of symptoms in response to chemical substances. Psychosom. Med. 65, 332-338.
39. Yamamoto, T., Fujimoto, Y., Shimura, T., and Sakai, N. (1995). Conditioned taste aversion in rats with excitotoxic brain lesions. Neurosci. Res. 22, 31-49.