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Volumn 26, Issue 2 B, 2006, Pages 1657-1668

Expression of p27KIP1, p21WAF1 and p53 does not correlate with prognosis in node-negative invasive ductal carcinoma of the breast

Author keywords

Breast carcinoma; p21; p27; p53; Prognosis

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HORMONE RECEPTOR; ONCOPROTEIN; PROTEIN P53; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; TP53 PROTEIN, HUMAN;

EID: 33645822560     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (65)
  • 1
    • 0024533068 scopus 로고
    • Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases
    • Carter CL, Allen C and Henson DE: Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer 63: 181-187, 1989.
    • (1989) Cancer , vol.63 , pp. 181-187
    • Carter, C.L.1    Allen, C.2    Hensont, D.E.3
  • 2
    • 0025279110 scopus 로고
    • How to use prognostic factors in axillary node-negative breast cancer patients
    • McGuire EG, Tandon AK, Allred DC et al: How to use prognostic factors in axillary node-negative breast cancer patients. J Natl Cancer Inst 82: 1006-1015, 1990.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1006-1015
    • McGuire, E.G.1    Tandon, A.K.2    Allred, D.C.3
  • 3
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer I. The value of histological grade in breast cancer: Experience from a larger study with long-term follow-up
    • Elston CW and Ellis IO: Pathological prognostic factors in breast cancer I. The value of histological grade in breast cancer: experience from a larger study with long-term follow-up. Histopathol 19: 403-410, 1991.
    • (1991) Histopathol , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 4
    • 0025916196 scopus 로고
    • Prognosis and breast cancer. Recognition of lethal and favorable prognostic types
    • Page DL: Prognosis and breast cancer. Recognition of lethal and favorable prognostic types. Am J Surg Pathol 75: 334-349, 1991.
    • (1991) Am J Surg Pathol , vol.75 , pp. 334-349
    • Page, D.L.1
  • 5
    • 15644376845 scopus 로고    scopus 로고
    • The importance of histologic grade of invasive breast carcinoma and response to chemotherapy
    • Pinder SE, Murray S, Ellis IO et al: The importance of histologic grade of invasive breast carcinoma and response to chemotherapy. Cancer 83: 1529-1539, 1998.
    • (1998) Cancer , vol.83 , pp. 1529-1539
    • Pinder, S.E.1    Murray, S.2    Ellis, I.O.3
  • 6
    • 0021813919 scopus 로고
    • Long term survivors after breast cancer
    • Dixon JM, Page DL, Anderson TJ et al: Long term survivors after breast cancer. Br J Surg 72: 445-448, 1985.
    • (1985) Br J Surg , vol.72 , pp. 445-448
    • Dixon, J.M.1    Page, D.L.2    Anderson, T.J.3
  • 7
    • 0026639108 scopus 로고
    • Prognostic factors and treatment decisions in node-negative breast cancer
    • McGuire W and Clark C: Prognostic factors and treatment decisions in node-negative breast cancer. N Engl J Med 326: 1756-1761, 1992.
    • (1992) N Engl J Med , vol.326 , pp. 1756-1761
    • McGuire, W.1    Clark, C.2
  • 8
    • 0028991396 scopus 로고
    • Mutation of cell cycle regulators
    • Cordon-Cardo C: Mutation of cell cycle regulators. Am J Pathol 147: 545-560, 1995.
    • (1995) Am J Pathol , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 9
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJM and Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.M.1    Roberts, J.M.2
  • 10
    • 0028179669 scopus 로고
    • KiP1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
    • KiP1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev 8: 9-22, 1994.
    • (1994) Genes Dev , vol.8 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3
  • 11
    • 0028909645 scopus 로고
    • Human cyclin E, a nuclear protein essential for Gl to S phase transition
    • Ohtsubo M, Theodoras AM, Schumacher J et al: Human cyclin E, a nuclear protein essential for Gl to S phase transition. Mol Cell Biol 75: 2612-2624, 1995.
    • (1995) Mol Cell Biol , vol.75 , pp. 2612-2624
    • Ohtsubo, M.1    Theodoras, A.M.2    Schumacher, J.3
  • 12
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-S phase progression
    • Sherr CJ and Roberts JM: CDK inhibitors: positive and negative regulators of G1-S phase progression. Genes Dev 13: 1501-1512, 1999.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 13
    • 0034738420 scopus 로고    scopus 로고
    • WAF1/cip1: More than a break to the cell cycle?
    • WAF1/cip1: more than a break to the cell cycle? Bioch Bioph Acta 1471: M43-M56, 2000.
    • (2000) Bioch Bioph Acta , vol.1471
    • Dotto, G.P.1
  • 14
    • 0037304898 scopus 로고    scopus 로고
    • New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment?
    • Coqueret O: New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 13: 65-70, 2003.
    • (2003) Trends Cell Biol , vol.13 , pp. 65-70
    • Coqueret, O.1
  • 15
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N et al: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of cyclin-dependent kinases. Cell 5: 805-816, 1993.
    • (1993) Cell , vol.5 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3
  • 16
    • 0027717617 scopus 로고
    • P21 a universal inhibitor of cyclin kinases
    • Xiong Y, Hannon GJ, Zhang H et al: P21 a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993.
    • (1993) Nature , vol.366 , pp. 701-704
    • Xiong, Y.1    Hannon, G.J.2    Zhang, H.3
  • 17
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumour suppression
    • El-Deiry WS, Tokino T, Velculescu VE et al: WAF1, a potential mediator of p53 tumour suppression. Cell 75: 817-825, 1993.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 18
    • 0028236846 scopus 로고
    • Induction of WAF1/CIP1 by a p53 independent pathway
    • Michielli P, Chedid M, Lin D et al: Induction of WAF1/CIP1 by a p53 independent pathway. Cancer Res 54: 3391-3395, 1994.
    • (1994) Cancer Res , vol.54 , pp. 3391-3395
    • Michielli, P.1    Chedid, M.2    Lin, D.3
  • 19
    • 0027109075 scopus 로고
    • P53, guardian of the genome
    • Lane DP: P53, guardian of the genome. Nature 358: 15-16, 1992.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 20
    • 0027728976 scopus 로고
    • How p53 suppresses cell growth
    • Marx J: How p53 suppresses cell growth. Science 262: 1644-1645, 1993.
    • (1993) Science , vol.262 , pp. 1644-1645
    • Marx, J.1
  • 21
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine AJ: P53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 22
    • 16944363001 scopus 로고    scopus 로고
    • Decreased levels of the cell cycle inhibitor p27(kip) protein: Prognostic implications in primary breast cancer
    • Catzavelos C, Bhattacharya N, Ung YC et al: Decreased levels of the cell cycle inhibitor p27(kip) protein: prognostic implications in primary breast cancer. Nature Med 3: 227-230, 1997.
    • (1997) Nature Med , vol.3 , pp. 227-230
    • Catzavelos, C.1    Bhattacharya, N.2    Ung, Y.C.3
  • 23
    • 0031048716 scopus 로고    scopus 로고
    • Expression of cell cycle regulators p27kip and cyclin E alone and in combination, correlate with survival in young breast cancer patients
    • Porter PL, Malone KE, Heagerty PJ et al: Expression of cell cycle regulators p27kip and cyclin E alone and in combination, correlate with survival in young breast cancer patients. Nature Med 3: 222-225, 1997.
    • (1997) Nature Med , vol.3 , pp. 222-225
    • Porter, P.L.1    Malone, K.E.2    Heagerty, P.J.3
  • 24
    • 0030894787 scopus 로고    scopus 로고
    • The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas
    • Tan P, Cady B, Wanner M et al: The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas. Cancer Res 57: 1259-1263, 1997.
    • (1997) Cancer Res , vol.57 , pp. 1259-1263
    • Tan, P.1    Cady, B.2    Wanner, M.3
  • 25
    • 0033012770 scopus 로고    scopus 로고
    • P27 expression as a prognostic factor of breast cancer in Taiwan
    • Chu JS, Huang CS and Chang KJ: P27 expression as a prognostic factor of breast cancer in Taiwan. Cancer Lett 141: 123-130, 1999.
    • (1999) Cancer Lett , vol.141 , pp. 123-130
    • Chu, J.S.1    Huang, C.S.2    Chang, K.J.3
  • 26
    • 0032796973 scopus 로고    scopus 로고
    • kiP1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation
    • kiP1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation. Breast Cancer Res Treat 55: 161-167, 1999.
    • (1999) Breast Cancer Res Treat , vol.55 , pp. 161-167
    • Han, S.1    Park, K.2    Kim, H.Y.3
  • 27
    • 0345369680 scopus 로고    scopus 로고
    • Prognostic impact of cyclin-dependent kinase inhibitor p27/kip1 in node-positive breast cancer
    • Tsuchiya A, Zhang, GJ and Kanno M: Prognostic impact of cyclin-dependent kinase inhibitor p27/kip1 in node-positive breast cancer. J Surg Oncol 70: 230-4, 1999.
    • (1999) J Surg Oncol , vol.70 , pp. 230-234
    • Tsuchiya, A.1    Zhang, G.J.2    Kanno, M.3
  • 28
    • 0032587341 scopus 로고    scopus 로고
    • KiP1 and apoptosis in human breast cancer
    • KiP1 and apoptosis in human breast cancer. Br J Cancer 79: 1572-1578, 1999.
    • (1999) Br J Cancer , vol.79 , pp. 1572-1578
    • Wu, J.1    Shen, Z.Z.2    Lu, J.-S.3
  • 29
    • 0035170004 scopus 로고    scopus 로고
    • Expression of cell cycle regulator p27 is correlated to the prognosis and ER expression in breast carcinoma patients
    • Nohara T, Ryo T, Iwamoto S et al: Expression of cell cycle regulator p27 is correlated to the prognosis and ER expression in breast carcinoma patients. Oncology 60: 94-100, 2001.
    • (2001) Oncology , vol.60 , pp. 94-100
    • Nohara, T.1    Ryo, T.2    Iwamoto, S.3
  • 30
    • 0032902972 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p27/kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma
    • Gillett CE, Smith P, Peters G et al: Cyclin-dependent kinase inhibitor p27/kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. J Pathol 187: 200-206, 1999.
    • (1999) J Pathol , vol.187 , pp. 200-206
    • Gillett, C.E.1    Smith, P.2    Peters, G.3
  • 31
    • 0032780931 scopus 로고    scopus 로고
    • Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node negative breast carcinoma patients
    • Reed W, Florenes VA, Holm R et al: Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node negative breast carcinoma patients. Virchows Arch 435: 116-124, 1999.
    • (1999) Virchows Arch , vol.435 , pp. 116-124
    • Reed, W.1    Florenes, V.A.2    Holm, R.3
  • 32
    • 0033917031 scopus 로고    scopus 로고
    • P27(kip1) expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up
    • Barbareschi M, van Tinteren H, Mauri FA et al: p27(kip1) expression in breast carcinomas: an immunohistochemical study on 512 patients with long-term follow-up. Int J Cancer 89: 236-241, 2000.
    • (2000) Int J Cancer , vol.89 , pp. 236-241
    • Barbareschi, M.1    Van Tinteren, H.2    Mauri, F.A.3
  • 33
    • 0034688189 scopus 로고    scopus 로고
    • Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast
    • Leong AC, Hanby AM, Potts HW et al: Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast. Int J Cancer 89: 26-31, 2000.
    • (2000) Int J Cancer , vol.89 , pp. 26-31
    • Leong, A.C.1    Hanby, A.M.2    Potts, H.W.3
  • 34
    • 0033731947 scopus 로고    scopus 로고
    • Prognostic significance of biologic markers in node-negative breast cancer patients: A prospective study
    • Volpi A, De Paola F, Nanni O et al: Prognostic significance of biologic markers in node-negative breast cancer patients: a prospective study. Breast Cancer Res Treat 63: 181-192, 2000.
    • (2000) Breast Cancer Res Treat , vol.63 , pp. 181-192
    • Volpi, A.1    De Paola, F.2    Nanni, O.3
  • 35
    • 0037377745 scopus 로고    scopus 로고
    • Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and benefit from one course of perioperative chemotherapy in patients with negative lymph node status
    • Spataro VJ, Litman H, Viale G et al: Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and benefit from one course of perioperative chemotherapy in patients with negative lymph node status. Cancer 97: 1591-1600, 2003.
    • (2003) Cancer , vol.97 , pp. 1591-1600
    • Spataro, V.J.1    Litman, H.2    Viale, G.3
  • 36
    • 0026724877 scopus 로고
    • Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancers
    • Thor AD, Moore DH II, Edgerton SM et al: Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. J Natl Cancer Inst 84: 845-855, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 845-855
    • Thor, A.D.1    Moore II, D.H.2    Edgerton, S.M.3
  • 37
    • 0027394794 scopus 로고
    • Association of p53 protein expression with tumour cell proliferation rate and clinical outcome in node negative breast cancer
    • Allred DC, Clark GM, Elledge R et al: Association of p53 protein expression with tumour cell proliferation rate and clinical outcome in node negative breast cancer. J Natl Cancer Inst 85: 200-206, 1993.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 200-206
    • Allred, D.C.1    Clark, G.M.2    Elledge, R.3
  • 38
    • 0027278584 scopus 로고
    • Immunohistochemical detection of p53 protein in mammary carcinoma: An important new independent indicator of prognosis?
    • Barnes DM, Dublin EA, Fisher CJ et al: Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis? Hum Pathol 24: 469-476, 1993.
    • (1993) Hum Pathol , vol.24 , pp. 469-476
    • Barnes, D.M.1    Dublin, E.A.2    Fisher, C.J.3
  • 39
    • 0026659891 scopus 로고
    • Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node negative breast cancer patients
    • Isola J, Viskorpi T, Holli Kaija et al: Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node negative breast cancer patients J Natl Cancer Inst 84: 1109-1114, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1109-1114
    • Isola, J.1    Viskorpi, T.2    Kaija, H.3
  • 40
    • 0028986873 scopus 로고
    • P53 in node-negative breast carcinoma: An immunohistochemical study of epidemiologic risk factors, histologic features, and prognosis
    • Rosen PP, Lesser ML, Arroyo CD et al: p53 in node-negative breast carcinoma: an immunohistochemical study of epidemiologic risk factors, histologic features, and prognosis. J Clin Oncol 13: 821-830, 1995.
    • (1995) J Clin Oncol , vol.13 , pp. 821-830
    • Rosen, P.P.1    Lesser, M.L.2    Arroyo, C.D.3
  • 41
    • 0029883680 scopus 로고    scopus 로고
    • A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer
    • Michalides R, Hageman P, van Tinteren H et al: A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer. Br J Cancer 73: 728-734, 1996.
    • (1996) Br J Cancer , vol.73 , pp. 728-734
    • Michalides, R.1    Hageman, P.2    Van Tinteren, H.3
  • 42
    • 0009941731 scopus 로고    scopus 로고
    • Prognostic factors in breast cancer
    • College of American Pathologists Consensus Statement 1999
    • Fitzgibbons PL, Page DL, Weaver D et al: Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 124: 966-978, 2000.
    • (2000) Arch Pathol Lab Med , vol.124 , pp. 966-978
    • Fitzgibbons, P.L.1    Page, D.L.2    Weaver, D.3
  • 43
    • 0034651899 scopus 로고    scopus 로고
    • The prognostic value of p53 and c-erb B2 immunostaining is overrated for patients with lymph node negative breast carcinoma
    • Reed W, Hannisdal E, Boehler PJ et al: The prognostic value of p53 and c-erb B2 immunostaining is overrated for patients with lymph node negative breast carcinoma. Cancer 88: 804-813, 2000.
    • (2000) Cancer , vol.88 , pp. 804-813
    • Reed, W.1    Hannisdal, E.2    Boehler, P.J.3
  • 44
    • 0029665943 scopus 로고    scopus 로고
    • WAF1 immunohistochemical expression in breast carcinoma: Correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival
    • WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival. Br J Cancer 74: 208-215, 1996.
    • (1996) Br J Cancer , vol.74 , pp. 208-215
    • Barbareshi, M.1    Caffo, O.2    Doglioni, C.3
  • 45
    • 0030667191 scopus 로고    scopus 로고
    • P21/waf1/cip1 and mdm-2 expression in breast carcinoma patients is related to prognosis
    • Jiang M, Shao ZM, Wu J et al: P21/waf1/cip1 and mdm-2 expression in breast carcinoma patients is related to prognosis. Int J Cancer 74: 529-534, 1997.
    • (1997) Int J Cancer , vol.74 , pp. 529-534
    • Jiang, M.1    Shao, Z.M.2    Wu, J.3
  • 46
    • 0031004664 scopus 로고    scopus 로고
    • P21 (Waf/Cip 1) and p53 protein expression in breast cancer
    • Wakasugi E, Kobayashi T, Tamaki Y et al: p21 (Waf/Cip 1) and p53 protein expression in breast cancer. Am J Clin Pathol 107: 684-691, 1997.
    • (1997) Am J Clin Pathol , vol.107 , pp. 684-691
    • Wakasugi, E.1    Kobayashi, T.2    Tamaki, Y.3
  • 47
    • 2642641300 scopus 로고    scopus 로고
    • P21/WAF1/CIP1 is associated with cyclin D1/CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma
    • Rey MJ, Fernandez PL, Jares P et al: p21/WAF1/CIP1 is associated with cyclin D1/CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma J Pathol 184: 265-271, 1998.
    • (1998) J Pathol , vol.184 , pp. 265-271
    • Rey, M.J.1    Fernandez, P.L.2    Jares, P.3
  • 49
    • 0348134963 scopus 로고    scopus 로고
    • Expression of the cell cycle regulatory proteins p34/cdc2, p21/waf1, and p53 in node negative invasive ductal breast carcinoma
    • Kourea HP, Koutras AK, Scopa CD et al: Expression of the cell cycle regulatory proteins p34/cdc2, p21/waf1, and p53 in node negative invasive ductal breast carcinoma. J Clin Pathol Mol 56: 328-335, 2003.
    • (2003) J Clin Pathol Mol , vol.56 , pp. 328-335
    • Kourea, H.P.1    Koutras, A.K.2    Scopa, C.D.3
  • 50
    • 0033205230 scopus 로고    scopus 로고
    • P27 expression, a cyclin dependent kinase inhibitor in breast carcinoma
    • Barbareshi M: p27 expression, a cyclin dependent kinase inhibitor in breast carcinoma. Adv Clin Pathol 3: 119-127, 1999.
    • (1999) Adv Clin Pathol , vol.3 , pp. 119-127
    • Barbareshi, M.1
  • 51
    • 0036569518 scopus 로고    scopus 로고
    • High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas. Relation to e-cadherin alterations, proliferative activity, and ploidy of the tumors
    • Kouvaraki M, Gorgoulis VG, Rassidakis GZ et al: High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas. Relation to e-cadherin alterations, proliferative activity, and ploidy of the tumors. Cancer 94: 2454-2465, 2002.
    • (2002) Cancer , vol.94 , pp. 2454-2465
    • Kouvaraki, M.1    Gorgoulis, V.G.2    Rassidakis, G.Z.3
  • 52
    • 18644370396 scopus 로고    scopus 로고
    • Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    • Viglietto G, Motti ML, Bruni P et al: Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 8: 1136-1144, 2002.
    • (2002) Nat Med , vol.8 , pp. 1136-1144
    • Viglietto, G.1    Motti, M.L.2    Bruni, P.3
  • 53
    • 18644376449 scopus 로고    scopus 로고
    • PKB/Akt phosphorylates p27 and opposes p27-mediated G1-arrest
    • Liang J, Zubovitz J, Petrocelli T et al: PKB/Akt phosphorylates p27 and opposes p27-mediated G1-arrest. Nat Med 8: 1153-1160, 2002.
    • (2002) Nat Med , vol.8 , pp. 1153-1160
    • Liang, J.1    Zubovitz, J.2    Petrocelli, T.3
  • 54
    • 0032762177 scopus 로고    scopus 로고
    • Expression of p27/kip and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas. The emerging role of p27 in malignant transformation of neurofibromas
    • Kourea HP, Cordon-Cardo C, Dudas M et al: Expression of p27/kip and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas. The emerging role of p27 in malignant transformation of neurofibromas. Am J Pathol 755: 1885-1891, 1999.
    • (1999) Am J Pathol , vol.755 , pp. 1885-1891
    • Kourea, H.P.1    Cordon-Cardo, C.2    Dudas, M.3
  • 55
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the cdk inhibitor p27 and its deregulation in cancer
    • Slingerland J and Pagano M: Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 183: 10-17, 2000.
    • (2000) J Cell Physiol , vol.183 , pp. 10-17
    • Slingerland, J.1    Pagano, M.2
  • 56
    • 0343627996 scopus 로고    scopus 로고
    • P27(kip1) expression in rectal cancer correlates with disease-free survival
    • Gunther K, Jung A, Volker U et al: p27(kip1) expression in rectal cancer correlates with disease-free survival. J Surg Res 92: 78-84, 2000.
    • (2000) J Surg Res , vol.92 , pp. 78-84
    • Gunther, K.1    Jung, A.2    Volker, U.3
  • 57
    • 0030223056 scopus 로고    scopus 로고
    • Prognostic value of p21/waf1 and p53 expression in breast carcinoma: An immunohistochemical study of 261 patients with long-term follow-up
    • Caffo O, Doglioni C, Veronese S et al: Prognostic value of p21/waf1 and p53 expression in breast carcinoma: an immunohistochemical study of 261 patients with long-term follow-up. Clin Cancer Res 2: 1591-1599, 1996.
    • (1996) Clin Cancer Res , vol.2 , pp. 1591-1599
    • Caffo, O.1    Doglioni, C.2    Veronese, S.3
  • 59
    • 0037338643 scopus 로고    scopus 로고
    • P21/WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis
    • Pellikainen MJ, Pekola TT, Ropponen KM et al: p21/WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis. J Clin Pathol 56: 214-220, 2003.
    • (2003) J Clin Pathol , vol.56 , pp. 214-220
    • Pellikainen, M.J.1    Pekola, T.T.2    Ropponen, K.M.3
  • 60
    • 0346485798 scopus 로고    scopus 로고
    • WAF1/ciP1 expression is correlated with her-2/neu in breast cancer and is an independent predictor of prognosis
    • WAF1/ciP1 expression is correlated with her-2/neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Res 5: 242-249, 2003.
    • (2003) Breast Cancer Res , vol.5 , pp. 242-249
    • Winters, Z.E.1    Leek, R.D.2    Bradburn, M.J.3
  • 61
    • 0030973878 scopus 로고    scopus 로고
    • New functional activities for the p21 family of CDK inhibitors
    • LaBaer J, Garrett MD, Stevenson LF et al: New functional activities for the p21 family of CDK inhibitors. Genes Develop 11: 847-862, 1997.
    • (1997) Genes Develop , vol.11 , pp. 847-862
    • Labaer, J.1    Garrett, M.D.2    Stevenson, L.F.3
  • 62
    • 0027361822 scopus 로고
    • Prognostic significance of p53 gene alterations in node negative breast cancer
    • Elledge RM, Fuqua SA, Clark GM et al: Prognostic significance of p53 gene alterations in node negative breast cancer. Breast Cancer Res Treat 26: 225-235, 1993.
    • (1993) Breast Cancer Res Treat , vol.26 , pp. 225-235
    • Elledge, R.M.1    Fuqua, S.A.2    Clark, G.M.3
  • 63
    • 0031777159 scopus 로고    scopus 로고
    • Analysis of p53 gene mutation by polymerase chain reaction-single strand conformation polymorphism provides independent prognostic information in node-negative breast cancer
    • Iacopetta B, Grieu F, Powell B et al: Analysis of p53 gene mutation by polymerase chain reaction-single strand conformation polymorphism provides independent prognostic information in node-negative breast cancer. Clin Cancer Res 4: 1597-1602, 1998.
    • (1998) Clin Cancer Res , vol.4 , pp. 1597-1602
    • Iacopetta, B.1    Grieu, F.2    Powell, B.3
  • 64
    • 0032814777 scopus 로고    scopus 로고
    • Somatic mutations in the p53 gene and prognosis in breast cancer: A meta-analysis
    • Pharoah PD, Day NE, Caldas C et al: Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis. Br J Cancer 80: 1968-1973, 1999.
    • (1999) Br J Cancer , vol.80 , pp. 1968-1973
    • Pharoah, P.D.1    Day, N.E.2    Caldas, C.3
  • 65
    • 0037374686 scopus 로고    scopus 로고
    • CIP1/WAF1 in antiproliferative effect of ZD1839 ("Iressa"), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells
    • CIP1/WAF1 in antiproliferative effect of ZD1839 ("Iressa"), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. J Cell Physiol 795: 139-150, 2003.
    • (2003) J Cell Physiol , vol.795 , pp. 139-150
    • Di Gennaro, E.1    Barbarino, M.2    Bruzzese, F.3


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