메뉴 건너뛰기




Volumn 55, Issue 2, 1999, Pages 161-167

Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation

Author keywords

Breast cancer; Cell cycle; Cyclin dependent kinase inhibitor; Differentiation; p27Kip1; Prognosis; Proliferation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOPHOSPHAMIDE; FLUOROURACIL; METHOTREXATE; MONOCLONAL ANTIBODY; PROTEIN P27;

EID: 0032796973     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1006258222233     Document Type: Article
Times cited : (37)

References (27)
  • 1
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells
    • Slingerland JM, Hengst L, Pan CH, Alexander D, Stampfer MR, Reed SI: A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol Cell Biol 14: 3683-3694, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.H.3    Alexander, D.4    Stampfer, M.R.5    Reed, S.I.6
  • 3
    • 0030614492 scopus 로고    scopus 로고
    • Aberrant p27Kip1 expression in endocrine and other tumors
    • Lloyd RV, Jin L, Qian X, Kulig E: Aberrant p27Kip1 expression in endocrine and other tumors. Am J Pathol 150: 401-407, 1997
    • (1997) Am J Pathol , vol.150 , pp. 401-407
    • Lloyd, R.V.1    Jin, L.2    Qian, X.3    Kulig, E.4
  • 4
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhihitor p27 in aggressive colorectal carcinomas
    • Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M: Increased proteasome-dependent degradation of the cyclin-dependent kinase inhihitor p27 in aggressive colorectal carcinomas. Nature Med 3: 231-234, 1997
    • (1997) Nature Med , vol.3 , pp. 231-234
    • Loda, M.1    Cukor, B.2    Tam, S.W.3    Lavin, P.4    Fiorentino, M.5    Draetta, G.F.6    Jessup, J.M.7    Pagano, M.8
  • 6
    • 0031048716 scopus 로고    scopus 로고
    • Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlates with survival in young breast cancer patients
    • Porter PL, Malone KE, Heagerty PJ, Alexander GM, Gatti LA, Firpo EJ, Daling JR, Roberts JM: Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlates with survival in young breast cancer patients. Nature Med 3: 222-225, 1997
    • (1997) Nature Med , vol.3 , pp. 222-225
    • Porter, P.L.1    Malone, K.E.2    Heagerty, P.J.3    Alexander, G.M.4    Gatti, L.A.5    Firpo, E.J.6    Daling, J.R.7    Roberts, J.M.8
  • 8
    • 0030058757 scopus 로고    scopus 로고
    • Mutational analysis of the human cyclin-dependent kinase inhibitor p27Kip1 in primary breast carcinomas
    • Ferrando AA, Balbin M, Pendas AM, Vizoso F, Velasco G, Lopez-Otin C: Mutational analysis of the human cyclin-dependent kinase inhibitor p27Kip1 in primary breast carcinomas. Human Genetics 97: 91-94, 1996
    • (1996) Human Genetics , vol.97 , pp. 91-94
    • Ferrando, A.A.1    Balbin, M.2    Pendas, A.M.3    Vizoso, F.4    Velasco, G.5    Lopez-Otin, C.6
  • 11
    • 0027197664 scopus 로고
    • Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 13q32 and its expression in breast carcinoma
    • Rasmussen UB, Wolf C, Mattei MG, Belloeq JP, Chambon P, Rio MC, Basset P: Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 13q32 and its expression in breast carcinoma. Cancer Res 53: 4096-4101, 1993
    • (1993) Cancer Res , vol.53 , pp. 4096-4101
    • Rasmussen, U.B.1    Wolf, C.2    Mattei, M.G.3    Belloeq, J.P.4    Chambon, P.5    Rio, M.C.6    Basset, P.7
  • 12
    • 0030855876 scopus 로고    scopus 로고
    • Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas
    • Yashui W, Kubo Y, Semba S, Yokozaki H, Tahara E: Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas. Jpn J Cancer Res 88: 625-629, 1997
    • (1997) Jpn J Cancer Res 88 , vol.88 , pp. 625-629
    • Yashui, W.1    Kubo, Y.2    Semba, S.3    Yokozaki, H.4    Tahara, E.5
  • 13
    • 0030952105 scopus 로고    scopus 로고
    • Abnormal expression of four novel molecular markers represents a highly aggressive phenotype in breast cancer: Immunohistochemical assay of p53, nm23, erbB-2, and cathepsin D protein
    • Han S, Yun IJ, Noh DY, Choe KJ, Song SY, Chi JG: Abnormal expression of four novel molecular markers represents a highly aggressive phenotype in breast cancer: Immunohistochemical assay of p53, nm23, erbB-2, and cathepsin D protein. J Surg Oncol 65: 22-27, 1997
    • (1997) J Surg Oncol , vol.65 , pp. 22-27
    • Han, S.1    Yun, I.J.2    Noh, D.Y.3    Choe, K.J.4    Song, S.Y.5    Chi, J.G.6
  • 14
    • 0031883583 scopus 로고    scopus 로고
    • Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity
    • Jordan RCK, Bradley G, Slingerland J: Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity. Am J Pathol 152: 585-590, 1998
    • (1998) Am J Pathol , vol.152 , pp. 585-590
    • Jordan, R.C.K.1    Bradley, G.2    Slingerland, J.3
  • 15
    • 0029133503 scopus 로고
    • Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells
    • Kranenburg O, Scharnhorst V, Van de Eb A, Zantema A: Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells. J Cell Biol 131: 227-234, 1995
    • (1995) J Cell Biol , vol.131 , pp. 227-234
    • Kranenburg, O.1    Scharnhorst, V.2    Van De Eb, A.3    Zantema, A.4
  • 18
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66, 1994
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 20
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima H, Hunter P: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74, 1994
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, P.2
  • 23
    • 0031042746 scopus 로고    scopus 로고
    • Cancer prognostics: Past, present and p27. Reduced expression of the p27 cell cycle inhibitor predicts poor cancer patient survival
    • Steeg PS, Abrams JS: Cancer prognostics: Past, present and p27. Reduced expression of the p27 cell cycle inhibitor predicts poor cancer patient survival. Nature Med 3: 152-154, 1997
    • (1997) Nature Med , vol.3 , pp. 152-154
    • Steeg, P.S.1    Abrams, J.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.