The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation

Cell Research

Volumn 15, Issue 5, 2005, Pages 379-386

  Wang, Zhi Xin ^a   Jiang, Chun Sun ^a   Liu, Lei ^a   Wang, Xiao Hui ^a   Jin, Hai Jing ^a   Wu, Qiao ^b   Chen, Quan ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b XIAMEN UNIVERSITY   (China)

Author keywords

Akt PKB; Apoptosis; Arsenic trioxide; Cell differentiation; Preadipocyte

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; CCAAT ENHANCER BINDING PROTEIN ALPHA; ORGANOARSENIC DERIVATIVE; OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; RETINOID X RECEPTOR ALPHA;

ADIPOCYTE; ANIMAL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CYTOLOGY; DRUG EFFECT; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL CYCLE; CELL DIFFERENTIATION; HUMANS; MICE; OXIDES; PPAR GAMMA; PROTO-ONCOGENE PROTEINS C-AKT; RETINOID X RECEPTOR ALPHA;

EID: 27844451587     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290305     Document Type: Article

References (24)

1. Tseng CH, Tai TY, Chong CK et al. Long-term arsenic exposure and incidence of non-insulin-dependent diabetes mellitus: a cohort study in arseniasis-hyperendemic villages in Taiwan. Environ Health Perspect 2000; 108:847-51.
2. Engel RR, Hopenhayn-Rich C, Receveur O et al. Vascular effects of chronic arsenic exposure: a review. Epidemiol Rev 1994; 16:184-209.
3. Rahman M, Tondel M, Ahmad SA et al. Hypertension and arsenic exposure in Bangladesh. Hypertension 1999; 33:74-8.
4. Tseng CH, Chong CK, Chen CJ et al. Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan. Atherosclerosis 1996; 120:125-33.
5. Germolec DR, Spalding J, Yu HS et al. Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors. Am J Pathol 1998; 153:1775-85.
6. Soignet SL, Maslak P, Wang ZG et al. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med 1998; 339:1341-8.
7. Zhang TD, Chen GQ, Wang ZG et al. Arsenic trioxide, a therapeutic agent for APL. Oncogene 2001; 20:7146-53.
8. Zheng Y, Shi Y, Tian C et al. Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene 2004; 23:1239-47
9. 3) induces apoptosis through activation of Bax in hematopoietic cells. Oncogene 2005; Epub ahead of print.
10. Hamadeh HK, Vargas M, Lee E et al. Arsenic disrupts cellular levels of p53 and mdm2: a potential mechanism of carcinogenesis. Biochem Biophys Res Commun 1999; 263:446-9.
11. Trouba KJ, Glanzer JG, Vorce RL. Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure. Toxicol Sci 1999; 50:72-81.
12. Kachinskas DJ, Phillips MA, Qin Q et al. Arsenate perturbation of human keratinocyte differentiation. Cell Growth Differ 1994; 5:1235-41.
13. Trouba KJ, Wauson EM, Vorce RL. Sodium arsenite inhibits terminal differentiation of murine C3H 10T1/2 preadipocytes. Toxicol Appl Pharmacol 2000; 168:25-35.
14. Wu Z, Rosen ED, Brun R et al. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 1999; 3:151-8.
15. Magun R, Burgering BM, Coffer PJ et al. Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 1996; 137:3590-3.
16. Hill MM, Clark SF, Tucker DF et al. A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol. 1999; 19:7771-81.
17. Yamaguchi H, Wang HG The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change Oncogene. 2001; 20:7779-86.
18. Neshat MS, Raitano AB, Wang HG et al.The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and - independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol. 2000; 20:1179-86.
19. Shim MJ, Kim HJ, Yang SJ et al. Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. J Biochem Mol Biol 2002; 35:377-83.
20. Chen F, Lu Y, Zhang Z et al. Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite. J Biol Chem 2001; 276:11414-9.
21. Wauson EM, Langan AS, Vorce RL. Sodium arsenite inhibits and reverses expression of adipogenic and fat cell-specific genes during in vitro adipogenesis. Toxicol Sci 2002; 65:211-9.
22. Altiok S, Xu M, Spiegelman BM. PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev 1997; 11:1987-98.
23. Wakino S, Kintscher U, Kim S et al. Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1→ S transition in vascular smooth muscle cells. J Biol Chem 2000; 275:22435-41.
24. Trouba KJ, Wauson EM, Vorce RL. Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling. Toxicol Appl Pharmacol 2000; 164:161-70.