Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV

Journal of Peptide Science

Volumn 12, Issue 4, 2006, Pages 267-278

  Perez T ^a   Ercilla, G ^b   Chan, W C ^c   Haro, I ^a  

^a DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Chimeric peptides; Circular dichroism; Cyclic peptides; Diagnosis; ELISA; Fourier transformed infrared spectroscopy; GBV C HGV; Solid phase peptide synthesis

Indexed keywords

EPITOPE; SYNTHETIC PEPTIDE; VIRUS ANTIGEN; VIRUS PROTEIN;

ANTIGEN RECOGNITION; ANTIGENICITY; ARTICLE; CHIMERA; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME IMMUNOASSAY; HEPATITIS G VIRUS; INFRARED SPECTROSCOPY; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SOLID PHASE SYNTHESIS;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CIRCULAR DICHROISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FLAVIVIRIDAE INFECTIONS; GB VIRUS C; IMMUNOENZYME TECHNIQUES; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS;

GB VIRUS C;

EID: 33645813808     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.719     Document Type: Article

References (39)

1. Stapleton JT. GB virus type C/hepatitis G virus. Semin. Liver Dis. 2003: 23: 137-148.
2. Halasz R, Weiland O, Sallberg M. GB virus C/hepatitis G virus. Scand. J. Infect. Dis. 2001; 33: 572-580.
3. Siebert DJ, Bowden DS, Tracy SL, Hardikar W. Prevalence of hepatitis g/GBV-C in a healthy paediatric population. J. Paediatr. Child Health 2002; 38: 423.
4. Chu C, Hwang S, Luo J, Wang Y, Lu R, Lai C, Tsay S, Li C, Wu J, Chang F, Lee S. Clinical, virological, immunological, and pathological significance of GB virus C/hepatitis G infection in patients with chronic hepatitis C. Hepatol. Res. 2001; 19: 225-236.
5. Williams CF, Klinzman D, Yamashita TE, Xiang J, Polgreen PM, Rinaldo C, Liu C, Phair J, Margolick JB, Zdunek D, Hess G, Stapleton JT. Persistent GB virus C infection and survival in HIV-infected men. N. Engl. J. Med. 2004; 350: 981-990.
6. Dille BJ, Surowy TK, Gutierrez PA, Coleman PF, Knigge MF, Carrick RJ, Aach RD, Hollinger FB, Stevens CE, Barbosa LH, Nemo GJ, Mosley JW, Dawson GJ, Mushahwar IK. An ELISA for detection of antibodies to the E2 protein of GB virus C. J. Infect. Dis. 1997; 175: 458-461.
7. Tacke M, Schmolke S, Schlueter V, Sauleda S, Esteban JI, Tanaka E, Kiyosawa K, Alter HJ, Schmitt U, Hess G, Ofenloch-Haehnle B, Engel AM. Humoral immune response to the E2 protein of hepatitis G virus is associated with long-term recovery from infection and reveals a high frequency of hepatitis G virus exposure among healthy blood donors. Hepatology 1997; 26: 1626-1633.
8. Thomas DL, Vlahov D, Alter HJ, Hunt JC, Marshall R, Astemborski J, Nelson KE. Association of antibody to GB virus C (hepatitis G virus) with viral clearance and protection from reinfection. J. Infect. Dis. 1998; 177: 539-542.
9. Kunkel U, Hohne M, Berg T, Hopf U, Kekule AS, Frosner G, Pauli G, Schreier E. Quality control study on the performance of GB virus C/hepatitis G virus PCR. J. Hepatol. 1998; 28: 978-984.
10. Tacke M, Kiyosawa K, Stark K, Schlueter V, Ofenloch-Haehnle B, Hess G, Engel AM. Detection of antibodies to a putative hepatitis G virus envelope protein. Lancet 1997; 349: 318-320.
11. Dawson GJ, Chau KH, Cabal CM, Yarbough PO, Reyes GR, Mushahwar IK. Solid-phase enzyme-linked immunosorbent assay for hepatitis E virus IgG and IgM antibodies utilizing recombinant antigens and synthetic peptides. J. Virol. Methods 1992; 38: 175-186.
12. Plagemann PG. Epitope specificity of monoclonal antibodies to the N-protein of porcine reproductive and respiratory syndrome virus determined by ELISA with synthetic peptides. Vet. Immunol. Immunopathol. 2005; 104: 59-68.
13. Gomara MJ, Riedemann S, Vega I, Ibarra H, Ercilla G, Haro I. Use of linear and multiple antigenic peptides in the immunodiagnosis of acute hepatitis A virus infection. J. Immunol. Methods 2000; 234: 23-34.
14. El Awady M, El Demellawy M, Khalil S, Galal D, Goueli S. Synthetic peptide-based immunoassay as a supplemental test for HCV infection. Clin. Chim. Acta 2002; 325: 39-46.
15. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 1998; 101: 273-281.
16. Toniutto P, Fabris C, Barbone F, Tisminetzky SG, Liani D, Galai T, Barillari G, Biffoni F, Gasparini V, Pirisi M. Immunoreactivity to putative B-cell epitopes of hepatitis G virus polyprotein in viremic and nonviremic subjects. Clin. Diagn. Lab. Immunol. 1999; 6: 573-576.
17. Rojo N, Ercilla G, Haro I. GB virus C (GBV-C)/hepatitis G virus (HGV): towards the design of synthetic peptides-based biosensors for immunodiagnosis of GBV-C/HGV infection. Curr. Protein Pept. Sci. 2003; 4: 291-298.
18. Hernandez M, Selles ME, Pozo PL, Gomez I, Melchor A. Antigenicity of chimeric synthetic peptides based on HTLV-1 antigens and the impact of epitope orientation. Biochem. Biophys. Res. Commun. 2000: 276: 1085-1088.
19. Drakopoulou E, Uray K, Mezo G, Price MR, Vita C, Hudecz F. Synthesis and antibody recognition of mucin 1 (MUC1)-alpha-conotoxin chimera. J. Pept. Sci. 2000; 6: 175-185.
20. Dyson HJ, Wright PE. Antigenic peptides. FASEB J. 1995; 9: 37-42.
21. Mezo G, Majer Z, Vass E, Jimenez MA, Andreu D, Hudecz F. Conformational study of linear and cyclic peptides corresponding to the 276-284 epitope region of HSV gD-1. Biophys. Chem. 2003: 103: 51-65.
22. Schellekens GA, Visser H, de Jong BA, van den Hoogen FH, Hazes JM, Breedveld FC, van Venrooij WJ. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000; 43: 155-163.
23. Chan WC, Bycroft BW, Evans DJ, White PD. A novel 4-aminobenzyl ester-based carboxy-protecting group for synthesis of atypical peptides by Fmoc-but solid-phase chemistry. J. Chem. Soc., Chem. Commun. 1995; 2209-2210.
24. Cudic M, Wade JD, Otvos L. Convenient synthesis of a head-to-tail cyclic peptide containing an expanded ring. Tetrahedron Lett. 2000: 41: 4527-4531.
25. Lobley A, Whitmore L, Wallace BA. Dichroweb: an interactive website for the analysis of protein secondary structure from circular dichroism data. Bioinformatics 2002; 18: 211-212.
26. Chen YH, Yang JT, Chan KH. Determination of the helix and beta form of proteins in aqueous solution by circular dichroism. Biochemistry 1974: 13: 3350-3359.
27. Hopp TP, Woods KR. Prediction of protein antigenic determinants from amino acid sequences. Proc. Natl. Acad. Sci. U. S. A. 1981; 78: 3824-3828.
28. Welling GW, Weijer WJ, van der ZR, Welling-Wester S. Prediction of sequential antigenic regions in proteins. FEBS Lett. 1985; 188: 215-218.
29. Johnson T, Liley M, Cheesebright TJ, Begum F. Problems in the synthesis of cyclic peptides through use of the Dmab protecting group. J. Chem. Soc. Perkin Trans. 1 2000; 2811-2820
30. Péréz T, Gómez A, Sanmarti R, Vinas O, Ercilla G, Haro I. Use of [Cit312,314] filaggrin (306-324) analogue for the diagnosis of rheumatoid arthritis. Conformational study by circular dichroism and Fourier transformed infrared spectroscopy. Lett. Pept. Sci. 2003; 9: 291-300.
31. Formaggio F, Crisma M, Rossi P, Scrimin P, Kaptein B, Broxterman QB, Kamphuis J, Toniolo C. The first water-soluble 3(10)-helical peptides. Chemistry 2000; 6: 4498-4504.
32. Perczel A, Hollosi M. Turns. In Circular Dichroism and the Conformational Analysis of Biomolecules, Fasman GD (ed.). Plenum Press: New York, 1996; 285-380.
33. Wright-Minogue J, Yao N, Zhang R, Butkiewicz NJ, Baroudy BM, Lau JY, Hong Z. Cross-genotypic interaction between hepatitis C virus NS3 protease domains and NS4A cofactors. J. Hepatol. 2000; 32: 497-504.
34. Belyaev AS, Chong S, Novikov A, Kongpachith A, Masiarz FR, Lim M, Kim JP. Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins. J. Virol. 1998: 72: 868-872.
35. Pilot-Matias TJ, Muerhoff AS, Simons JN, Leary TP, Buijk SL, Chalmers ML, Erker JC, Dawson GJ, Desai SM, Mushahwar IK. Identification of antigenic regions in the GB hepatitis viruses GBV-A, GBV-B, and GBV-C. J. Med. Virol. 1996; 48: 329-338.
36. Soffredini R, Rumi M, Lampertico P, Aroldi A, Tarantino A, Ponticelli C, Colombo M. Increased detection of antibody to hepatitis C virus in renal transplant patients by third-generation assays. Am. J. Kidney Dis. 1996; 28: 437-440.
37. Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 1989; 244: 362-364.
38. Marin MH, Pena LP, Tanty CR, Higginson CD, Arenas MA, Noguerol KR, Leon CS. Antigenic activity of three chimeric synthetic peptides of the transmembrane (gp41) and the envelope (gp120) glycoproteins of HIV-1 virus. Prep. Biochem. Biotechnol. 2004: 34: 227-237.
39. Rosa C, Osborne S, Garetto F, Griva S, Rivella A, Calabresi G, Guaschino R, Bonelli F. Epitope mapping of the NS4 and NS5 gene products of hepatitis C virus and the use of a chimeric NS4-NS5 synthetic peptide for serodiagnosis. J. Virol. Methods 1995; 55: 219-232.