Humoral immune response to the E2 protein of hepatitis G virus is associated with long-term recovery from infection and reveals a high frequency of hepatitis G virus exposure among healthy blood donors

Hepatology

Volumn 26, Issue 6, 1997, Pages 1626-1633

  Tacke, Michael ^a   Schmolke, Susanne ^a   Schlueter, Volker ^a   Sauleda, Silvia ^b   Esteban, Juan I ^b   Tanaka, Eiji ^c   Kiyosawa, Kendo ^c   Alter, Harvey J ^d   Schmitt, Urban ^a   Hess, Georg ^a   Ofenloch Haehnle, Beatus ^a   Engel, Alfred M ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; PROTEIN E2; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS G VIRUS; HEPATITIS VIRUS; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; LONG TERM CARE; NONHUMAN; NORMAL HUMAN; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; SEQUENCE HOMOLOGY; VIRUS EXPRESSION; VIRUS TRANSMISSION;

EID: 0030702768     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260635     Document Type: Article

References (27)

1. Linnen J, Wages Jr. J, Zhang-Keck ZY, Fry KE, Krawczynski KZ, Alter H, Koonin E, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science 1996;271:505-508.
2. Simons JN, Leary TP, Dawson GJ, Pilot-Matias TJ, Muerhoff AS, Schlauder GG, Desai SM, et al. Isolation of novel virus-like sequences associated with human hepatitis. Nat Med 1995;1:564-569.
3. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ, Erker JC, Chalmers ML, Schlauder GG, et al. Sequence and genomic organization of GBV-C: a novel member of the Flaviviridae associated with human non-A-E hepatitis. J Med Virol 1996;48:60-67.
4. Simons JN, Desai SM, Schultz DE, Lemon SM, Mushahwar IK. Translation initiation in GB viruses A and C: evidence for internal ribosome entry and implications for genome organization. J Virol 1996;70:6126-6135.
5. Masuko K, Mitsui T, Iwano K, Yamazaki C, Okuda K, Meguro T, Murayama N, et al. Infection with hepatitis GB virus C in patients on maintenance hemodialysis. N Engl J Med 1996;334:1485-1490.
6. Schlueter V, Schmolke S, Stark K, Hess G, Ofenloch-Haehnle B, Engel AM. Reverse transcription-PCR detection of hepatitis G virus. J Clin Microbiol 1996;34:2660-2664.
7. Stark K, Bienzle U, Hess G, Engel AM, Hegenscheid B, Schlueter V. Detection of the hepatitis G virus genome among injecting drug users, homosexual and bisexual men, and blood donors. J Infect Dis 1996;174:1320-1323.
8. Tacke M, Kiyosawa K, Stark K, Schlueter V, Ofenloch-Haehnle B, Hess G, Engel AM. Detection of antibodies to a putative hepatitis G virus envelope protein. Lancet 1997;349:318-320, 736.
9. Pilot-Matias TJ, Carrick RJ, Coleman PF, Leary TP, Surowy TK, Simons JN, Muerhoff AS, et al. Expression of the GB virus C E2 glycoprotein using the semliki forest virus vector system and its utility as a serologic marker. Virology 1996;225:282-292.
10. Dille BJ, Surowy TK, Gutierrez RA, Coleman PF, Knigge MF, Carrich RJ, Aach RD, et al. An ELISA for detection of antibodies of the E2 protein of GB virus C. J Infect Dis 1997;175:458-461.
11. Crouse GF, Simonsen CC, McEwan RN, Schimke RT. Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells. J Biol Chem 1982;257:7887-7897.
12. Hopp TP, Prickett KS, Price VL, Libby RT, March CJ, Cerretti DP, Urdal DL, et al. A short polypeptide marker sequence useful for recombinant protein identification and purification. Biotechnology 1988;6:1204-1210.
13. Jacobs K, Shoemaher C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A, Seehra J, et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 1985;313:806-810.
14. Elder JH, Alexander S. Endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both highmannose and complex glycoproteins. Proc Natl Acad Sci USA 1982;79:4540-4544.
15. Weiner AJ, Brauer MJ, Rosenblatt J, Richman KH, Tung J, Crawford K, Bonino F, et ai. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 1991;180:842-848.
16. Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K. Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochem Biophys Res Commun 1991;175:220-228.
17. Weiner AJ, Geysen HM, Christopherson C, Hall JE, Mason TJ, Saracco G, Bonino F, et al. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci USA 1992;89:3468-3472.
18. Sawyer WA. The history of yellow fever since the New Orleans epidemic of 1905. South Med J 1931;3:291-296.
19. Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 1996;2:1104-1108.
20. Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996;272:54-60.
21. McDonnell WM, Lucey MR. Hepatitis C infection. Current Opin Infect Dis 1995;8:384-390.
22. Lesniewsky R, Okasinski G, Carrick R, Van Sant C, Desai S, Johnson R, Scheffel J, et al. Antibody to hepatitis C virus second envelope (HCV-E2) glycoprotein: a new marker of HCV infection closely associated with viremia. J Med Virol 1995;45:415-422.
23. Simmonds P. Variability of hepatitic C virus. HEPATOLOGY 1995;21:570-583.
24. Cerny A, Chisari FV. Immunological aspects of HCV infection. Intervirology 1994;37:119-125.
25. Farci P, Shimoda A, Wong D, Cabezon T, De Gioannis D, Strazzera A, Shimizu Y, et al. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci USA 1996;93:15394-15399.
26. Erker JC, Simons JN, Muerhoff AS, Leary TP, Chalmers ML, Desai SM, Mushahwar IK. Molecular cloning and characterization of a GB virus C isolate from a patient with non-A-E hepatitis. J Gen Virol 1996;77:2713-2720.
27. Nakao H, Okamoto H, Fukuda M, Tsuda F, Mitsui T, Masuko K, Iizuka H, et al. Mutation rate of GB virus C/hepatitis G virus over the entire genome and in sungenomic regions. Virology 1997;233:43-50.