High-affinity peptide transporter PEPT2 (SLC15A2) of the zebrafish Danio rerio: Functional properties, genomic organization, and expression analysis

Physiological Genomics

Volumn 24, Issue 3, 2006, Pages 207-217

  Romano, Alessandro ^a   Kottra, Gabor ^b   Barca, Amilcare ^a   Tiso, Natascia ^c   Maffia, Michele ^a   Argenton, Francesco ^c   Daniel, Hannelore ^b   Storelli, Carlo ^a   Verri, Tiziano ^a  

^a UNIVERSITY OF SALENTO   (Italy)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Otic vesicle; pept2; Peptide transport; Two electrode voltage clamp; Whole mount in situ hybridization; Xenopus laevis oocytes

Indexed keywords

CARRIER PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA; PEPTIDE TRANSPORTER 2; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; EXON; EXPRESSED SEQUENCE TAG; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION SEQUENCE; GENE LOCATION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC MODEL; GENOME ANALYSIS; INTESTINE; INTRON; KIDNEY; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; OPEN READING FRAME; PRIORITY JOURNAL; TISSUE DISTRIBUTION; XENOPUS LAEVIS; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; EAR, INNER; ELECTROPHYSIOLOGY; EMBRYO, NONMAMMALIAN; FEMALE; IN SITU HYBRIDIZATION; LARVA; MALE; MEMBRANE TRANSPORT PROTEINS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; OOCYTES; PHYLOGENY; RNA, MESSENGER; SEQUENCE ANALYSIS; SYMPORTERS; TISSUE DISTRIBUTION; VERTEBRATES; XENOPUS; ZEBRAFISH;

ANIMALIA; AVES; DANIO RERIO; MAMMALIA; RODENTIA; VERTEBRATA; XENOPUS LAEVIS;

EID: 33645797601     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00227.2005     Document Type: Article

References (53)

1. Amasheh S, Wenzel U, Weber WM, Clauss W, and Daniel H. Electrophysiological analysis of the function of the mammalian renal peptide transporter expressed in Xenopus laevis oocytes. J Physiol 504: 169-174, 1997.
2. Ballard WW. Morphogenetic movements and fate maps of vertebrates. Am Zool 21: 391-399, 1981.
3. Berger UV and Hediger MA. Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat Embryol (Berl) 199: 439-449, 1999.
4. Boll M, Herget M, Wagener M, Weber WM, Markovich D, Biber J, Clauss W, Murer H, and Daniel H. Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc Natl Acad Sci USA 93: 284-289, 1996.
5. Briggs JP. The zebrafish: a new model organism for integrative physiology. Am J Physiol Regul Integr Comp Physiol 282: R3-R9, 2002.
6. Chen H, Pan Y, Wong EA, Bloomquist JR, and Webb KE Jr. Molecular cloning and functional expression of a chicken intestinal peptide transporter (cPepT1) in Xenopus oocytes and Chinese hamster ovary cells. J Nutr 132: 387-393, 2002.
7. +-coupled peptide transporter PepT2. J Biol Chem 274: 2773-2779, 1999.
8. Chen Z. Simple modifications to increase specificity of the 5′ RACE procedure. Trends Genet 12: 87-88, 1996.
9. 2β. Trends Biochem Sci 26: 7-9, 2001.
10. Daniel H and Kottra G. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflügers Arch 447: 610-618, 2004.
11. Daniel H and Rubio-Aliaga I. An update on renal peptide transporters. Am J Physiol Renal Physiol 284: F885-F892, 2003.
12. Dooley K and Zon LI. Zebrafish: a model system for the study of human disease. Curr Opin Genet Dev 10: 252-256, 2000.
13. Döring F, Walter J, Will J, Föcking M, Boll M, Amasheh S, Clauss W, and Daniel H. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J Clin Invest 101: 2761-2767, 1998.
14. Fei YJ, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, Boron WF, and Hediger MA. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368: 563-566, 1994.
15. Fei YJ, Sugawara M, Liu JC, Li HW, Ganapathy V, Ganapathy ME, and Leibach FH. cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. Biochim Biophys Acta 1492: 145-154, 2000.
16. Groneberg DA, Rubio-Aliaga I, Nickolaus M, Döring F, Fischer A, and Daniel H. Direct visualization of peptide uptake activity in the central nervous system of the rat. Neurosci Lett 364: 32-36, 2004.
17. Haddon C and Lewis J. Early ear development in the embryo of the zebrafish, Danio rerio. J Comp Neurol 365: 113-128, 1996.
18. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, and Schilling TF. Stages of embryonic development of the zebrafish. Dev Dyn 203: 253-310, 1995.
19. Kottra G and Daniel H. Bidirectional electrogenic transport of peptides by the proton-coupled carrier PEPT1 in Xenopus laevis oocytes: its asymmetry and symmetry. J Physiol 536: 495-503, 2001.
20. Kumar S, Tamura K, Jakobsen IB, and Nei M. MEGA2: molecular evolutionary genetics analysis software. Bioinformatics 17: 1244-1245, 2001.
21. +/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem 270: 6456-6463, 1995.
22. +/peptide cotransporter family, from human kidney. Biochim Biophys Acta 1235: 461-466, 1995.
23. Miyamoto K, Shiraga T, Morita K, Yamamoto H, Haga H, Taketani Y, Tamai I, Sai Y, Tsuji A, and Takeda E. Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. Biochim Biophys Acta 1305: 34-38, 1996.
24. Müller F, Blader P, and Strähle U. Search for enhancers: teleost models in comparative genomic and transgenic analysis of cis regulatory elements. Bioessays 24: 564-572, 2002.
25. Novotny A, Xiang J, Stummer W, Teuscher NS, Smith DE, and Keep RF. Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus. J Neurochem 75: 321-328, 2000.
26. Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, and Smith DE. Mechanisms of cefadroxil uptake in the choroid plexus: studies in wildtype and PEPT2 knockout mice. J Pharmacol Exp Ther 308: 462-467, 2004.
27. Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, and Smith DE. Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice. Pharm Res 21: 1680-1685, 2004.
28. Pan Y, Wong EA, Bloomquist JR, and Webb KE Jr. Expression of a cloned ovine gastrointestinal peptide transporter (oPepT1) in Xenopus oocytes induces uptake of oligopeptides in vitro. J Nutr 131: 1264-1270, 2001.
29. Pichler FB, Laurenson S, Williams LC, Dodd A, Copp BR, and Love DR. Chemical discovery and global gene expression analysis in zebrafish. Nat Biotechnol 21: 879-883, 2003.
30. Romero MF, Kanai Y, Gunshin H, and Hediger MA. Expression cloning using Xenopus laevis oocytes. Methods Enzymol 296: 17-51, 1998.
31. Rubio-Aliaga I and Daniel H. Mammalian peptide transporters as targets for drug delivery. Trends Pharmacol Sci 23: 434-440, 2002.
32. Rubio-Aliaga I, Boll M, and Daniel H. Cloning and characterization of the gene encoding the mouse peptide transporter PEPT2. Biochem Biophys Res Commun 276: 734-741, 2000.
33. Rühl A, Hoppe S, Frey I, Daniel H, and Schemann M. Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system. J Comp Neurol 490: 1-11, 2005.
34. Rutherford K, Parkhill J, Crook J, Horsnell T, Rice P, Rajendream MA, and Barrell B. Artemis: sequence visualization and annotation. Bioinformatics 16: 944-955, 2000.
35. Saito H, Okuda M, Terada T, Sasaki S, and Inui KI. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther 275: 1631-1637, 1995.
36. Saitou N and Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4: 406-425, 1987.
37. Shen H, Smith DE, Keep RF, and Brosius FC 3rd. Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. Mol Pharmacol 1: 248-256, 2004.
38. Shen H, Smith DE, Keep RF, Xiang J, and Brosius FC 3rd. Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J Biol Chem 278: 4786-4791, 2003.
39. Shu C, Shen H, Teuscher NS, Lorenzi PJ, Keep RF, and Smith DE. Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture. J Pharmacol Exp Ther 301: 820-829, 2002.
40. Sober MA. CRC Handbook of Biochemistry. Cleveland, OH: CRC, 1968.
41. Steiner HY, Naider F, and Becker JM. The PTR family: a new group of peptide transporters. Mol Microbiol 16: 825-834, 1995.
42. Teuscher NS, Keep RF, and Smith DE. PEPT2-mediated uptake of neuropeptides in rat choroid plexus. Pharm Res 18: 807-813, 2001.
43. Teuscher NS, Novotny A, Keep RF, and Smith DE. Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine. J Pharmacol Exp Ther 294: 494-499, 2000.
44. Teuscher NS, Shen H, Shu C, Xiang J, Keep RF, and Smith DE. Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice. J Neurochem 89: 375-382, 2004.
45. Thisse C, Thisse B, Schilling TF, and Postlethwait JH. Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development 119: 1203-1215, 1993.
46. Thompson JD, Higgins DG, and Gibson TJ. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680, 1994.
47. Van L, Pan YX, Bloomquist JR, Webb KE Jr, and Wong EA. Developmental regulation of a turkey intestinal peptide transporter (PepT1). Poult Sci 84: 75-82, 2005.
48. Verri T, Kottra G, Romano A, Tiso N, Peric M, Maffia M, Boll M, Argenton F, Daniel H, and Storelli C. Molecular and functional characterisation of the zebrafish (Danio rerio) PEPT1-type peptide transporter. FEBS Lett 549: 115-122, 2003.
49. Wang H, Fei YJ, Ganapathy V, and Leibach FH. Electrophysiological characteristics of the proton-coupled peptide transporter PEPT2 cloned from rat brain. Am J Physiol Cell Physiol 275: C967-C975, 1998.
50. Waterman RE and Bell DH. Epithelial fusion during early semicircular canal formation in the embryonic zebrafish, Brachydanio rerio. Anat Rec 210: 101-114, 1984.
51. Westerfield M. The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio). Eugene, OR: Univ. of Oregon Press, 1995.
52. Whitfield TT, Riley BB, Chiang MY, and Phillips B. Development of the zebrafish inner ear. Dev Dyn 223: 427-458, 2002.
53. Zhu T, Chen XZ, Steel A, Hediger MA, and Smith DE. Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2. Pharm Res 17: 526-532, 2000.