Effects of a complex mixture of therapeutic drugs at environmental levels on human embryonic cells

Environmental Science and Technology

Volumn 40, Issue 7, 2006, Pages 2442-2447

  Pomati, Francesco ^a,c   Castiglioni, Sara ^a   Zuccato, Ettore ^b   Fanelli, Roberto ^b   Vigetti, Davide ^a   Rossetti, Carlo ^a   Calamari, Davide ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPUTER SIMULATION; CONCENTRATION (PROCESS); ENVIRONMENTAL IMPACT; GENES; HEALTH RISKS; MORPHOLOGY; PHYSIOLOGY;

AQUATIC LIFE; ATENOLOL; EMBRYONIC CELLS; THERAPEUTIC DRUGS;

DRUG PRODUCTS;

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ATENOLOL; BEZAFIBRATE; BRONCHODILATING AGENT; CARBAMAZEPINE; CIPROFLOXACIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DIURETIC AGENT; FUROSEMIDE; GLUTATHIONE TRANSFERASE P1; HYDROCHLOROTHIAZIDE; IBUPROFEN; LINCOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OFLOXACIN; PROTEIN P16INK4A; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RANITIDINE; SALBUTAMOL; STRESS ACTIVATED PROTEIN KINASE; SULFAMETHOXAZOLE; SULFONAMIDE;

CELLS; COMPUTER SIMULATION; CONCENTRATION (PROCESS); DRUG PRODUCTS; ENVIRONMENTAL IMPACT; GENES; HEALTH RISKS; MORPHOLOGY; PHYSIOLOGY;

AQUATIC ENVIRONMENT; CELLS AND CELL COMPONENTS; DRUG; EMBRYONIC DEVELOPMENT; GENE EXPRESSION; MORPHOLOGY;

APOPTOSIS; AQUATIC ENVIRONMENT; ARTICLE; BIODEGRADATION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HEK293; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CONTAMINATION; DRUG METABOLISM; EMBRYO; EMBRYO CELL; ENVIRONMENTAL EXPOSURE; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; STRESS; TOXICITY TESTING;

CELL CYCLE; CELL LINE; EMBRYO; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; HUMANS;

EID: 33645773451     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es051715a     Document Type: Article

References (27)

1. Heberer, T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 2002, 131, 5-17.
2. Castiglioni, S.; Bagnati, R.; Calamari, D.; Fanelli, R.; Zuccato, E. A multiresidue analytical method using solid-phase extraction and HPLC-MS-MS to measure pharmaceuticals of different therapeutic classes in urban waste waters. J. Chromatogr. 2005, 1092, 206-215.
3. Castiglioni, S.; Bagnati, R.; Fanelli, R.; Pomati, F.; Calamari, D.; Zuccato, E. Removal of pharmaceuticals in sewage treatment plants in Italy. Environ. Sci. Technol. 2006, 40, 357-363.
4. Zuccato, E.; Calamari, D.; Natangelo, M.; Fanelli, R. Presence of therapeutic drugs in the environment. Lancet 2000, 355, 1789-1790.
5. Daughton, C. G.; Ternes, T. A. Pharmaceuticals and Personal care products in the environment: agents of subtle change? Environ. Health Perspect. 1999, 107, 907-938.
6. Boxall, A. B. A.; Koplin, D. W.; Sorensen, B. H.; Tolls, J. Are veterinary medicines causing environmental risk? Environ. Sci. Technol. 2003, 37, 287-294.
7. Pomati, F.; Netting, A. G.; Calamari, D.; Neilan, B. A. Effects of erythromycin, tetracycline and ibuprofen on the growth of Synechocystis sp. and Lemna minor. Aquat. Toxicol. 2004, 67, 387-396.
8. Cleuvers, M. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol. Lett. 2003, 142, 185-194.
9. Anway, M. D.; Cupp, A. S.; Uzumcu, M.; Skinner, M. K. Epigenetic transgenerational actions of endocrine disrupters and male fertility. Science 2005, 300, 1466-9.
10. Calamari, D.; Zuccato, E.; Castiglioni, S.; Bagnati, R.; Fanelli, R. A strategic survey of therapeutic drugs in the rivers Po and Lambro in northen Italy. Environ. Sci. Technol. 2003, 37, 1241-1248.
11. Castiglioni, S.; Fanelli, R.; Calamari, D.; Bagnati, R.; Zuccato, E. Methodological approaches for studying pharmaceuticals in the environment by comparing predicted and measured concentrations in river Po, Italy. Reg. Toxicol. Pharmacol. 2004, 39, 25-32.
12. Williams, T. D.; Gensberg, K.; Minchin, S. D.; Chipman, J. K. A DNA expression array to detect toxic stress response in European flounder (Platichthys flesus). Aquat. Toxicol. 2003, 65, 141-157.
13. Yu, Q.; Rose, J. H.; Zhang, H.; Pommier, Y. Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells. FEBS Lett. 2001, 505, 7-12.
14. Inoki, K.; Zhu, T.; Guan, K. L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115, 577-590.
15. 2 cytotoxicity in mouse renal proximal tubule cells. Kidney Int. 2004, 65, 1231-1239.
16. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
17. Calabrese, E. J.; Baldwin, L. A. Hormesis as a biological hypothesis. Environ. Health Perspect. 1998, 106, 357-62.
18. Carpenter, D. O.; Arcaro, K.; Spink, D. C. Understanding the human health effects of chemical mixtures. Environ. Health Perspect. 2002, 110, 25-42.
19. Dimri, G. P.; Lee, X.; Basile, G.; Acosta, M.; Scott, G.; Roskelley, C; Medrano, E. E.; Linskens, M.; Rubelj, I.; Pereira-Smith, O.; et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 9363-7.
20. Wang, W.; Martindale, J. L.; Yang, X.; Chrest, F. J.; Gorospe, M. Increased stability of the p16 mRNA with replicative senescence. EMBO J. 2005, Rep 6, 158-64.
21. Ben-Porath, I.; Weinberg, R. A. The signals and pathways activating cellular senescence. Int. J. Biochem. Cell. Biol. 2005, 37, 961-976.
22. Gray, J. V.; Petsko, G. A.; Johnston, G. C.; Ringe, D.; Singer, R. A.; Werner-Washburne, M. "Sleeping beauty": quiescence in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 2004, 68, 187-206.
23. Tang, D.; Wu, D.; Hirao, A.; Lahti, J. M.; Liu, L.; Mazza, B.; Kidd, V. J.; Mak, T. W.; Ingram, A. J. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J. Biol. Chem. 2002, 277, 12710-7.
24. Steegenga, W. T.; van Laar, T.; Riteco, N.; Mandarine, A.; Shvarts, A.; van der Eb, A. J.; Jochemsen, A. G. Adenovirus E1A proteins inhibit activation of transcription by p53. Mol. Cell. Biol. 1996, 16, 2101-2109.
25. Kamat, A. M,; DeHaven, J. I.; Lamm, D. L. Quinolone antibiotics: a potential adjunct to intravesical chemotherapy for bladder cancer. Urology 1999, 54, 56-61.
26. Abe, J.; Okuda, M.; Huang, Q.; Yoshizumi, M.; Berk, B. C. Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras. J. Biol. Chem. 2000, 275, 1739-1748.
27. Raijmakers, M. T.; Steegers, E. A.; Peters, W. H. Glutathione S-transferases and thiol concentrations in embryonic and early fetal tissues. Hum. Reprod. 2001, 16, 2445-2450.