Methodological approaches for studying pharmaceuticals in the environment by comparing predicted and measured concentrations in River Po, Italy

Regulatory Toxicology and Pharmacology

Volumn 39, Issue 1, 2004, Pages 25-32

  Castiglioni, Sara ^a,b   Fanelli, Roberto ^a   Calamari, Davide ^b   Bagnati, Renzo ^a   Zuccato, Ettore ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

Environment; Measured environmental concentration; Pharmaceuticals; Predicted environmental concentration

Indexed keywords

AMOXICILLIN; ATENOLOL; BEZAFIBRATE; CEFTRIAXONE; CIPROFLOXACIN; CLARITHROMYCIN; ENALAPRIL; ERYTHROMYCIN; FUROSEMIDE; HYDROCHLOROTHIAZIDE; IBUPROFEN; LINCOMYCIN; OMEPRAZOLE; RANITIDINE; SALBUTAMOL; SPIRAMYCIN;

ANALYTIC METHOD; ARTICLE; CALCULATION; DRUG CONTAMINATION; ENVIRONMENTAL RELEASE; FUNCTIONAL ASSESSMENT; GLACIAL MASS BALANCE; MEASUREMENT; NONPOINT SOURCE POLLUTION; POLLUTION MONITORING; PREDICTION; PRIORITY JOURNAL; RELIABILITY; WATER SAMPLING;

EID: 1642554773     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yrtph.2003.10.002     Document Type: Article

References (38)

1. Al-Ahmad A., Daschner F.D., Kummerer K. Biodegradability of Cefotiam, Ciprofloxacin, Meropnem, Penicillin G, and Sulfamethoxazole and inhibition of waste water bacteria. Arch. Environ. Contam. Toxicol. 37:1999;158-163.
2. Andrisano V., Gotti R., Leoni A., Cavrini V. Photodegradation studies on atenolol by liquid chromatography. J. Pharm. Biomed. Anal. 21:1999;851-857.
3. Burhenne J., Ludwing M., Nikoloudis P., Spiteller M. Photolytic degradation of fluoroquinolone carboxylic acid in aqueous solution-primary photolysis and half-lives. Environ. Sci. Pollut. Res. 4:1997;10-15.
4. Buser H.-R., Muller M.D., Theobald N. Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North Sea. Environ. Sci. Technol. 32:1998;188-192.
5. Calamari D., Zuccato E., Castiglioni S., Bagnati R., Fanelli R. A strategic survey of therapeutic drugs in the rivers Po and Lambro in northen Italy. Environ. Sci. Technol. 37:2003;1241-1248.
6. Concannon J., Lovitt H., Ramage M., Tai L.H., McDonald C., Sunderland V.B. Stability of aqueous solutions of amoxycillin sodium in the frozen and liquid states. Am. J. Hosp. Pharm. 43:1986;3027-3030.
7. Diaz-Cruz M.S., Lopez de Alda M.J., Barceló D. Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge. TrAC Trends Anal. Chem. 22(6):2003;340-351.
8. Ekpe A., Jacobsen T. Effect of various salts on the stability of lansoprazole, omeprazole and pantoprazole as determined by high-performance liquid chromatography. Drug Dev. Ind. Pharm. 25:1999;1057-1065.
9. Erah P.O., Barrett D.A., Shaw P.N. Ion-pair high-performance liquid chromatographic assay method for the assessment of clarithromycin stability in aqueous solution and in gastric juice. J. Chromatogr. B. Biomed. Appl. 682:1996;73-78.
10. Erickson B.E. Analyzing the ignored environmental contaminants. Environ. Sci. Technol. 36:2002;140A-145A.
11. European Agency for the Evaluation of Medicinal Products, EMEA, 2001. Draft CPMP. Discussion paper on environmental risk assessment of non-genetically modified organism (non-GMO) containing medicinal products for human use. CPMP/SWP/4447/00-draft. 25 January, 2001, London, UK.
12. European Agency for the Evaluation of Medicinal Products, EMEA, 2003. CPMP Safety Working Party. Note for guidance on environmental risk assessments of non-genetically modified organism (non-GMO) containing medicinal products for human use. CPMP/SWP/4447/00. 24 June, 2003, London, UK.
13. Garner S.S., Wiest D.B., Reynolds E.R. Jr. Stability of atenolol in an extemporaneously compounded oral liquid. Am. J. Hosp. Pharm. 51:1994;508-511.
14. Gavelchin J., Katz S.E. The pesticide of fecal-borne antibiotics in soil. J. AOAC Int. 77:1994;481-485.
15. Halling-Sorensen B., Holten Lutzhoft H.C., Andersen H.R., Ingerslev F. Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin. J. Antimicrob. Chemother. 46(Suppl. 1):2000;53-58.
16. Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131:2002;5-17.
17. Henshel K.P., Wenzel A., Dietrich M., Fliedner A. Environmental hazard assessment of pharmaceuticals. Regul. Toxicol. Pharmacol. 25:1997;220-225.
18. Johnson A.C., Sumpter J.P. Removal of endocrine-disrupting chemicals in activated sludge treatment works. Environ. Sci. Technol. 35:2001;4697-4703.
19. Kirit A.S., Das Gupta V., Kenneth R.S. Effect of pH, chlorobutanol, cysteine hydrochloride, ethylenediaminetetraacetic acid, propylene glycol, sodium metabisulfite, and sodium sulfite on furosemide stability in aqueous solutions. J. Pharm. Sci. 69:1980;594-596.
20. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones and other organic wastewater contaminants in US Streams 1999-2000: a national reconnaissance. Environ. Sci. Technol. 36:2002;1202-1211.
21. Kummerer K. Introduction. Kummerer K. Pharmaceuticals in the Environment. 2001;1-8 Springer-Verlag, Berlin, Germany.
22. Martindale, 1993. In: Reynolds, J.E.F. (Ed.) The Extra Pharmacopeia, 13th ed. The Pharmaceutical Press, London, UK.
23. Martinez-Pacheco R., Vila-Jato J.L., Gomez-Amoza J.L. Effect of different factors on stability of Ceftriaxone in solution. Farmaco. 42:1987;131-137.
24. Mathew M., Das Gupta V., Bailey R.E. Stability of omeprazole solutions at various pH values as determined by HPLC. Drug Dev. Ind. Pharm. 21:1995;965-971.
25. Nahata M.C., Morosco R.S., Hipple T.F. Stability of enalapril maleate in three extemporaneously prepared oral liquids. Am. J. Health Syst. Pharm. 55:1998;1155-1157.
26. Nakagawa Y., Itai S., Yoshida T., Nagai T. Physicochemical properties and stability in the acidic solution of a new macrolid antibiotic, clarithromycin, in comparison with erythromycin. Chem. Pharm. Bull. 40:1992;725-728.
27. Richardson M.L., Bowron J.M. The fate of pharmaceutical chemicals in the aquatic environment. J. Pharm. Pharmacol. 37:1985;1-12.
28. Sacher F., Lange T.F., Brauch H.-J., Blankenhorn I. Pharmaceuticals in groundwaters. Analytical methods and results of a monitoring program in Baden-Wuttemberg, Germany. J. Chromatogr. A. 938:2001;199-210.
29. Steger-Hartmann T., Lange R., Schweinfurth H. Environmetal risk assessment for the widely used iodinated X-ray contrast agent iopromide (ultravist). Ecotoxicol. Environ. Safety. 42:1999;274-281.
30. Straub J.O. Environmental risk assessment for new human pharmaceuticals in the European Union according to the draft guideline/discussion paper of January 2001. Toxicol. Lett. 131:2002;137-143.
31. Stuer-Lauridsen F., Birkved M., Hansen L.P., Holten Lutzhoft H-C., Halling-Sorensen B. Environmental risk assessment of human pharmaceuticals in Denmark after normal therapeutic use. Chemosphere. 40:2000;783-793.
32. Teraoka R., Otsuka M., Matsuda Y. Effect of temperature and relative humidity on the solid-state chemical stability of ranitidine hydrochloride. J. Pharm. Sci. 82:1993;601-604.
33. Ternes T.A. Occurrence of drugs in german sewage treatment plants and rivers. Water Res. 11:1998;3245-3260.
34. Therapeutic Drugs, 1991. (Sir C. Dollery Ed.), Churchill Livingstone, Edinburg, UK.
35. Tixier C., Singer H.P., Oellers S., Muller S.R. Occurence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters. Environ. Sci. Technol. 37:2003;1061-1068.
36. Weigel S., Kuhlmann J., Huhnerfuss H. Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea. Sci. Total Environ. 295:2002;131-141.
37. Zuccato E., Calamari D., Natangelo M., Fanelli R. Presence of therapeutic drugs in the environment. Lancet. 355:2000;1789-1790.
38. Zuccato E., Bagnati R., Fioretti F., Natangelo M., Calamari D., Fanelli R. Environmental loads and detection of pharmaceuticals in Italy. Kummerer K. Pharmaceuticals in the Environment. 2001;19-27 Springer-Verlag, Berlin, Germany.