Seven day oral supplementation with Cardax™ (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats

Molecular and Cellular Biochemistry

Volumn 283, Issue 1-2, 2006, Pages 23-30

  Gross, Garrett J ^a   Hazen, Stanley L ^b   Lockwood, Samuel F ^c  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c HAWAII BIOTECH INC   (United States)

Author keywords

Area at risk; Cardax ; Cardioprotection; Carotenoid derivatives; Disodium disuccinate astaxanthin; Infarct size; Ischemia reperfusion (I R) injury; Myocardial salvage; Rodent infarct model; Sprague Dawley rats

Indexed keywords

CARDAX; CAROTENOID; DISODIUM DISUCCINATE ASTAXANTHIN; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG; ASTAXANTHIN; BETA CAROTENE; CARDIOTONIC AGENT; DRUG DERIVATIVE; SUCCINIC ACID DERIVATIVE; SUCCINIC ACID MONO (4 (18 (4 (3 CARBOXYPROPIONYLOXY) 2,6,6 TRIMETHYL 3 OXOCYCLOHEX 1 ENYL) 3,7,12,16 TETRAMETHYLOCTADECA 1,3,5,7,9,11,13,15,17 NONAENYL) 3,5,5 TRIMETHYL 2 OXOCYCLOHEX 3 ENYL) ESTER; SUCCINIC ACID MONO-(4-(18-(4-(3-CARBOXYPROPIONYLOXY)-2,6,6-TRIMETHYL-3-OXOCYCLOHEX-1-ENYL)-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYL)-3,5,5-TRIMETHYL-2-OXOCYCLOHEX-3-ENYL) ESTER; XANTHOPHYLL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONARY REPERFUSION; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; IN VITRO STUDY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; VITAMIN SUPPLEMENTATION; ANIMAL; ANIMAL FOOD; BIOAVAILABILITY; CORONARY BLOOD VESSEL; DIET SUPPLEMENTATION; DRUG EFFECT; HEART MUSCLE REPERFUSION; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA; RODENTIA;

ADMINISTRATION, ORAL; ANIMAL FEED; ANIMALS; BETA CAROTENE; BIOLOGICAL AVAILABILITY; CARDIOTONIC AGENTS; CORONARY VESSELS; DIETARY SUPPLEMENTS; LIPID PEROXIDATION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SUCCINATES; XANTHOPHYLLS;

EID: 33645770524     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-2217-6     Document Type: Article

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