Embryonic growth - Associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development

Circulation Research

Volumn 98, Issue 6, 2006, Pages 846-855

  Wenzlau, Janet M ^a   Garl, Pamela J ^a   Simpson, Peter ^a   Stenmark, Kurt R ^a   West, James ^a   Artinger, Kristin B ^a   Nemenoff, Raphael A ^a   Weiser Evans, Mary C M ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

EGAP; N terminal acetyltransferase; TOR; Vascular cell proliferation; Vascular development

Indexed keywords

ACYLTRANSFERASE; PROTEIN SUBUNIT; TARGET OF RAPAMYCIN KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; PROTEIN KINASE;

ACETYLATION; AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COMPLEX FORMATION; EMBRYO DEVELOPMENT; EMBRYO GROWTH; ENZYME SUBSTRATE; GENETIC CONSERVATION; MAMMAL CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE; ANIMAL; CYTOLOGY; HUMAN; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; SMOOTH MUSCLE FIBER; TRANSGENIC ANIMAL; ZEBRA FISH;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL PROLIFERATION; EMBRYONIC DEVELOPMENT; HUMANS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTEIN KINASES; PROTEIN SUBUNITS; PROTEINS; ZEBRAFISH;

EID: 33645734898     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000214539.86593.7a     Document Type: Article

References (39)

1. Schwartz SM. The intima: a new soil. Circ Res. 1999;85:877-879.
2. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 84:767-801.
3. Yoshida T, Owens GK. Molecular determinants of vascular smooth muscle cell diversity. Circ Res. 2005;96:280-291.
4. Cook CL, Weiser MC, Schwartz PE, Jones CL, Majack RA. Developmentally timed expression of an embryonic growth phenotype in vascular smooth muscle cells. Circ Res. 1994;74:189-196.
5. Hungerford JE, Owens GK, Argraves WS, Little CD. Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markers. Dev Biol. 1996;178:375-392.
6. Lee SH, Hungerford JE, Little CD, Iruela-Arispe ML. Proliferation and differentiation of smooth muscle cell precursors occurs simultaneously during the development of the vessel wall. Dev Dyn. 1997;209:342-352.
7. Hungerford JE, Little CD. Developmental biology of the vascular smooth muscle cell: building a multilayered vessel wall. J Vasc Res. 1999;36:2-27.
8. Jain RK. Molecular regulation of vessel maturation. Nat Med. 2003;9:685-693.
9. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest. 1983;49:327-333.
10. Weiser-Evans MC, Quinn BE, Burkard MR, Stenmark KR. Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery smooth muscle cells after vascular injury. J Cell Physiol. 2000;182:12-23.
11. Weiser-Evans MC, Schwartz PE, Grieshaber NA, Belknap JK, Mourani PM, Majack RA, Stenmark KR. Novel embryonic genes are preferentially expressed by autonomously replicating rat embryonic and neointimal smooth muscle cells. Circ Res. 2000;87:608-615.
12. Polevoda B, Sherman F. Nalpha-terminal acetylation of eukaryotic proteins. J Biol Chem. 2000;275:36479-36482.
13. Polevoda B, Sherman F. Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem Biophys Res Commun. 2003;308:1-11.
14. Polevoda B, Sherman F. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J Mol Biol. 2003;325:595-622.
15. Polevoda B, Norbeck J, Takakura H, Blomberg A, Sherman F. Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae. EMBO J. 1999;18:6155-6168.
16. Polevoda B, Cardillo TS, Doyle TC, Bedi GS, Sherman F. Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem. 2003;278:30686-30697.
17. Singer JM, Shaw JM. Mdm20 protein functions with Nat3 protein to acetylate Tpml protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A. 2003;100:7644-7649.
18. Gendron RL, Adams LC, Paradis H. Tubedown-1, a novel acetyltransferase associated with blood vessel development. Dev Dyn. 2000;218:300-315.
19. Choi SC, Chang JY, Han JK. A novel Xenopus acetyltransferase with a dynamic expression in early development. Biochem Biophys Res Commun. 2001;285:1338-1343.
20. Sugiura N, Adams SM, Corriveau RA. An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. J Biol Chem. 2003;278:40113-40120.
21. Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Biochem J. 2005;386:433-443.
22. Polevoda B, Sherman F. NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. J Biol Chem. 2001;276:20154-20159.
23. Brown LA, Rodaway AR, Schilling TF, Jowett T, Ingham PW, Patient RK, Sharrocks AD. Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mech Dev. 2000;90:237-252.
24. Sato Y. Role of ETS family transcription factors in vascular development and angiogenesis. Cell Struct Funct. 2001;26:19-24.
25. Lawson ND, Weinstein BM. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol. 2002;248:307-318.
26. Sprague J, Doerry E, Douglas S, Westerfield M. The Zebrafish Information Network (ZFIN): a resource for genetic, genomic and developmental research. Nucleic Acids Res. 2001;29:87-90.
27. Ebert AM, Hume GL, Warren KS, Cook NP, Burns CG, Mohideen MA, Siegal G, Yelon D, Fishman MC, Garrity DM. Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proc Natl Acad Sci U S A. 2005;102:17705-17710.
28. Yelon D, Ticho B, Halpern ME, Ruvinsky I, Ho RK, Silver LM, Stainier DY. The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development. 2000;127:2573-2582.
29. Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004;23:3151-3171.
30. Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926-1945.
31. Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 2000;14:2712-2724.
32. Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G, Kozma SC. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 2004;24:9508-9516.
33. Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, Kiyama H, Yonezawa K, Yamanaka S. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol. 2004;24:6710-6718.
34. Mourani PM, Garl PJ, Wenzlau JM, Carpenter TC, Stenmark KR, Weiser-Evans MC. Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN. Circulation. 2004;109:1299-1306.
35. Yi XJ, Li XF, Yu FS. A novel epithelial wound-related gene is abundantly expressed in developing rat cornea and skin. Curr Eye Res. 2000;20:430-440.
36. Lee YJ, Wickner RB. MAK10, a glucose-repressible gene necessary for replication of a dsRNA viras of Saccharomyces cerevisiae, has T cell receptor alpha-subunit motifs. Genetics. 1992;132:87-96.
37. Behnia R, Panic B, Whyte JR, Munro S. Targeting of the Arf-like GTPase Ar13p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Nat Cell Biol. 2004;6:405-413.
38. Setty SR, Strochlic TI, Tong AH, Boone C, Burd CG. Golgi targeting of ARF-like GTPase Ar13p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Nat Cell Biol. 2004;6:414-419.
39. Jacinto E, Hall MN. Tor signaling in bugs, brain and brawn. Nat Rev Mol Cell Biol. 2003;4:117-126.