The neuroendocrine system as a model to evaluate experimental gene therapy

Current Gene Therapy

Volumn 6, Issue 1, 2006, Pages 125-129

  Hereñú, Claudia B ^a   Brown, Oscar A ^a   Sosa, Yolanda E ^a   Morel, Gustavo R ^a   Reggiani, Paula C ^a   Bellini, Maria J ^a   Goya, Rodolfo G ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

Brattleboro; Hypothalamus; LepR mutants; Neurodegeneration; Obesity; Pituitary tumors; Retinoblastoma mutant; Suicide transgene; TIDA neurons

Indexed keywords

ADENOVIRUS VECTOR; ARGIPRESSIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LEPTIN RECEPTOR; PARVOVIRUS VECTOR; PROLACTIN; PROOPIOMELANOCORTIN; SOMATOMEDIN C; CELL SURFACE RECEPTOR;

AGING; CELL PROLIFERATION; DIABETES INSIPIDUS; DISEASE MODEL; DOPAMINERGIC NERVE CELL; GENE MUTATION; HYPERINSULINEMIA; HYPERPHAGIA; HYPERPROLACTINEMIA; HYPOTHALAMUS; IN VIVO STUDY; INJECTION; MUTANT; NERVE DEGENERATION; NEUROENDOCRINE SYSTEM; NEUROLOGIC DISEASE; NONHUMAN; OBESITY; PARKINSON DISEASE; PROLACTIN RELEASE; REVIEW; RODENT; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WEIGHT REDUCTION; ANIMAL; FEMALE; GENE THERAPY; GENETICS; HUMAN; MALE; METHODOLOGY; MOUSE; NEUROSECRETION; RAT;

ADENOVIRIDAE; ANIMALIA; PARVOVIRUS; RODENTIA;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GENE THERAPY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MALE; MICE; NEUROSECRETORY SYSTEMS; RATS; RECEPTORS, CELL SURFACE;

EID: 33645728967     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652306775515556     Document Type: Review

References (35)

1. Ben-Jonathan, N., Arbogast, L. A. and Hyde, J. F. (1989) Neuroendocrine regulation of prolactin release. Prog. Neurobiol., 33:399-477
2. Bienemann A. S., Martin-Rendon, E, Cosgrave A. S., Glover C. P., Wong L. F., Kingsman S. M., Mitrophanous K. A., Mazarakis N. D., Uney J. B. (2003) Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin. Mol. Ther., 7:588-596
3. Bilang-Bleuel, A., Revah, F., Colin, P., Locquet, I., Robert, J. J., Mallet, J. and Horellou, P. (1997) Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. USA, 94: 8818-8823
4. Bowenkamp, K. E., Hoffman, A. F., Gerhardt, G. A., Henry, M. A., Biddle, P. T., Hoffer, B. J., Granholm, A. C. E. (1995) Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J Comp. Neurol., 355:479-489
5. Choi-Lundberg, D. L., Lin, Q., Chang, Y. N., Chiang, Y. L., Hay, C. M., Mohajeri, H., Davidson, B. L. and Bohn, M. C. (1997) Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science, 275:838-841
6. Cónsole, G., Gómez- Dumm, C. L, Brown, O. A. and Goya, R. G. (1997) Sexual dimorphism in the age-changes of the pituitary lactotrophs in rats. Mech. Age. Devel., 95: 157-166.
7. Dahlström, A. and Fuxe, K. (1964) Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scand., 62:1-55.
8. de Rijk, M. C., Breteler, M. M., Graveland, G. A., Ott, A., Grobbee, D. E., van der Meche, F. G. and Hofman, A. (1995) Prevalence of Parkinson's disease in the elderly: the Rotterdam study. Neurology, 45:2143-2146.
9. Franceschi, M., Camerlingo, M., Perego, L., Bottacchi, E. and Mamoli, A. (1988) Tubero-infundibular dopaminergic function in Parkinson's disease. Eur. Neurol., 28:117-119.
10. Gash, D. M., Zhang, Z., Ovadia, A., Cass, W. A., Yi, A., Simmerman, L., Russell, D.,Martin, D., Lapchak, P. A., Collins, F., Hoffer, B. J. and Gerhardt, G. A. (1996) Functional recovery in Parkinsonian monkeys treated with GDNF. Nature, 380:252-255.
11. Geddes, B. J., Harding, T. C., Lightman, S. L. and Uney, J. B. (1997) Longterm gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Nature Med, 3:1402-1404.
12. Geddes, B. J, Harding, T. C., Lightman, S. L, and Uney, J. B. (1999) Assessing viral gene therapy in neuroendocrine models. Front Neuroendocrinol., 20: 296-316.
13. Goudreau, J. L., Lindley, S.E., Lookingland, K. J. and Moore, K. E. (1992) Evidence that hypothalamic periventricular dopamine neurons innervate the intermediate lobe of the rat pituitary. Neuroendocrinology, 40:145-151
14. Goya, R.G., Lu, J. K. H. and Meites, J. (1990) Gonadal function in aging rats and its relation to pituitary and mammary pathology. Mech. Age. Devel., 56:77-88.
15. Gudelsky, G.A., Nansel, D. D. and Porter, J. C. (1981) Dopaminergic control of prolactin secretion in the aging male rat. Brain Res., 204:446-450.
16. Hereñú, C. B., Cristina, C., Rimoldi, O. J., Becú-Villalobos, D. and Goya, R. G. (2004) Construction and use of an adenoviral vector to express transgenic insulin-like growth factor I in the arcuate nucleus and substantia nigra of young and old rats; 12th International Congress of Endocrinology, Lisbon, Portugal, August 30-Septembre 4 (Abstract).
17. Hereñú, C. B., Cristina, C., Rimoldi, O. J., Becú, D., Zucolilli, G., Portiansky E. and Goya, R. G. (2005) IGF-I gene therapy in the brain of senile rats with dopaminergic neurodegeneration. Invited Symposium: 18th World Congress of Gerontology, Rio de Janeiro, 26-30 June (Abstract)
18. Kawano, H. and Daikoku, S. (1997) Functional topagraphy of the rat hypothalamic dopamine neuron systems: retrograde tracing and immunohistochemical study. J. Comp. Neurol., 265:242-253.
19. Kordower, J. H., Emborg, M. E., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L.,McBride, J., Chen, E. Y., Palfi, S., Roitberg, B. Z., Brown, W. D., Holden, J. E., Pyzalski, R., Taylor, M. D., Carvey, P., Ling, Z., Trono, D., Hantraye, P., Deglon, N. and Aebischer, P. (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science, 290: 767-773.
20. Li, G., Mobbs, C. V. and Scarpace, P. J. (2003) Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes, 52:1951-1957.
21. Lowenstein, P. R. and Castro, M. G. (2004) Recent advances in the pharmacology of neurological gene therapy. Curr. Op. Pharmacol., 4: 91-97.
22. Mandel, R. J., Spratt, S. K., Snyder, R. O. and Leff, S. E. (1997) Midbrain injection of recombinant adeno-associated virus encoding rat glial cell-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc. Natl. Acad Sci. USA, 94:14083-14088.
23. Mayeux, R., Marder, K., Cote, L. J., Denaro, J., Hemenegildo, N., Mejia, H., Tang, M. X., Lantigua, R., Wilder, D. and Gurland, B. (1995) The frequency of idiopathic Parkinson's disease by age, ethnic group and sex in northern Manhattan, 1988-1993. Am. J. Epidemiol., 142:820-827.
24. k) rats. Endocrinology,144: 2016-2024
25. Porter, J. C., Aguila-Mansilla, N., Ramin, S. M. and Kedzierski, W. (1994) Secretion by hypothalamic dopaminergic neurons of the aged brain. Neurobiol. Aging, 15:535-539.
26. Porter, J.C., Nansel, D.D., Gudelsky, G. A., Reymond, M. J., Pilotte, N. S., Foreman, M. M. and Tilders, F. J. H. (1980) Some aspects of hypothalamic and hypophysial secretion in aging rats. Peptides, 1:135-139.
27. Reymond, M. J. and Porter, J. C. (1981) Secretion of hypothalamic dopamine into pituitary stalk blood of aged female rats. Brain Res. Bull., 7:69-73.
28. Sánchez, H. L., Silva, L. B., Portiansky, E. L., Goya, R. G. and Zuccolilli, G. O. (2003) Impact of very old age on hypothalamic dopaminergic neurons in the female rat: A morphometric study. J. Comp. Neurol., 458:319-325.
29. Shavali, S., Ren, J. and Ebadi, M. (2003) Insulin-like growth factor-1 protects human dopaminergic SH-SY5Y cells from Salsolinol-induced toxicity Neurosci. Lett., 340: 79-82.
30. Shimohama, S., Sawada, H., Kitamura, Y. and Taniguchi, T. (2003) Disease model: Parkinson's disease. Trends Mol. Med., 9:360-365.
31. Tillet, Y. and Kitahama, K. (1998) Distribution of central catecholaminergic neurons: a comparison between ungulates, humans and other species. Histol. Histopathol., 13:1163-1177
32. Tomac, A., Lindqvist, E., Lin, L. F. H., Ögrenn, S. O., Young, D., Hoffer, B. J., Olson L.(1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature, 373:335-339
33. Tümer, N., Scarpace, P. J., Dogan, M. D., Broxson, C. S., Matheny, M., Yurek, D. M., Peden, C. S., Burger, C., Muzyczka, N. and Mandel, R. J (2005) Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity. Neurobiol. Aging, (in press).
34. Valtin H. (1992) Genetic models of diabetes insipidus. In: Handbook of Physiology, Ed. Windhager, E.E.. Oxford University Press, New York, pp. 1281-1316. 85:1296-1305.
35. Yoshida, M., Iwasaki, Y., Asai, M., Nigawara, T. and Oiso, Y. (2004) Gene therapy for central diabetes insipidus: effective antidiuresis by muscle-targeted gene transfer. Endocrinology, 145: 261-268.