Liver infiltrating mononuclear cells in children with type 1 autoimmune hepatitis

Journal of Clinical Pathology

Volumn 59, Issue 4, 2006, Pages 417-423

  De Biasio, M B ^a   Periolo, N ^a   Avagnina, A ^a   Garcia De Davila M T ^b   Ciocca, M ^b   Goni J ^b   De Matteo, E ^b   Galoppo, C ^b   Canero Velasco M C ^c   Fainboim, H ^a   Munoz A E ^e   Fainboim, L ^d   Chernavsky A C ^a  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^b HOSPITAL DE PEDIATRÍA PROF DR JUAN P GARRAHAN   (Argentina)

^c Pediatric Municipal Hospital of San Justo   (Argentina)

^d HOSPITAL F J MUÑIZ   (Argentina)

^e HOSPITAL DE GASTROENTEROLOGÍA DR CARLOS BONORINO UDAONDO   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; FAS LIGAND; PROTEIN BAK;

ADULT; ARTICLE; AUTOIMMUNE HEPATITIS; CELLULAR DISTRIBUTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LIVER BIOPSY; LIVER PARENCHYMA; MALE; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL;

ANTIGENS, CD56; ANTIGENS, CD57; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FAS LIGAND PROTEIN; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LEUKOCYTES, MONONUCLEAR; LIVER; MALE; MEMBRANE GLYCOPROTEINS; TUMOR NECROSIS FACTORS;

EID: 33645695376     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2005.028613     Document Type: Article

References (35)

1. Mackay IR. Immunological aspects of chronic active hepatitis. Hepatology 1983;3:724-8.
2. Czaja AJ. Natural history, clinical features, and treatment of autoimmune hepatitis. Seminars in Liver Disease 1984;4:1-12.
3. Johnson PJ, McFarlane IG. Meeting report: International Autoimmune Hepatitis Group. Hepatology 1993;18:998-1005.
4. Mieli-Vergani G, Vergani D. Immunological liver diseases in children. Semin Liver Dis 1998;18:271-9.
5. Cuarterolo M, García de Davila MT, Roig AH, et al. Hepatitis autoinmune, 8 años de experiencia. Med Infant 1995;11:237-41.
6. Di Sapio M, Focareta R, Caporaso N, et al. Phenotypic characterization of mononuclear cell infiltrate in chronic active hepatitis (CAH) of different etiology. Ric Clin Lab 1987;17:229-34.
7. Hashimoto E, Lindor KD, Homburger HA, et al. Immunohistochemical characterization of hepatic lymphocytes in primary biliary cirrhosis in comparison with primary sclerosing cholangitis and autoimmune chronic active hepatitis. Clin Proc Child Hosp Natl Med Cent 1993;68:1049-55.
8. Mosnier JF, Degott C, Marcellin P, et al. The intraportal lymphoid nodule and its environment in chronic active hepatitis C: an immunohistochemical study. Hepatology 1993;17:366-71.
9. Eggink HF, Houthoff HJ, Huitema S, et al. Cellular and humoral immune reactions in chronic active liver disease. I. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis. Clin Exp Immunol 1982;50:17-24.
10. Bach N, Thung SN, Schnaffner F. The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis. Hepatology 1992;15:572-7.
11. Vergani D, Choudhuri K, Bogdanos DP, et al. Pathogenesis of autoimmune hepatitis. Clin Liver Dis 2002;6:439-49.
12. Czaja AJ, Manns MP, McFarlane IG, et al. Autoimmune hepatitis: the investigational and clinical challenges. Hepatology 2000;31:1194-200.
13. Pando M, Larriba J, Fernandez GC, et al. Paediatric and adult forms of type I autoimmune hepatitis in Argentina: evidence for differential genetic predisposition. Hepatology 1999;30:1374-80.
14. Marcos Y, Fainboim HA, Capucchio M, et al. Two-locus involvement in the association of human leukocyte antigen with the extrahepatic manifestations of autoimmune chronic active hepatitis. Hepatology 1994;19:1371-4.
15. Fainboim L, Marcos Y, Pando M, et al. Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype. Hum Immunol 1994;41:146-50.
16. Fainboim L, Pando M, Capucchio M, et al. HLA and autoimmune hepatitis. In:Charron D, editor. HLA: genetic diversity of HLA functional and medical implication. Paris: EDK, 1997:418-22.
17. Donaldson PT, Doherty DG, Hayllar KM, et al. Susceptibility to autoimmune chronic active hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors. Hepatology 1991;13:701-6.
18. Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-38.
19. Napoli J, Bishop A, McGuinness P, et al. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 1996;24:759-65.
20. Morshed SA, Fukuma H, Kimura Y, et al. Interferon-gamma, interleukin (IL)-2 and IL-2 receptor expressions in hepatitis C virus-infected liver. Gastroenterol Jpn 1993;5:59-66.
21. Knodell R, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1:431-5.
22. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-9.
23. Taylor CR, Shi SR, Chen C, et al. Comparative study of antigen retrieval heating methods: Microwave, microwave and pressure cooker, autoclave, and steamer. Biotech Histochem 1996;71:263-70.
24. Jassem W, Koo DD, Cerundolo L, et al. Leukocyte infiltration and inflammatory antigen expression in cadaveric and living-donor livers before transplant. Transplantation 2003;75:2001-7.
25. Cherñavsky AC, Paladino N, Rubio AE, et al. Simultaneous expression of Th1 cytokines and IL-4 confers severe characteristics to type I autoimmune hepatitis in children. Hum Immunol 2004;65:683-91.
26. Matsuo I, Ikuno N, Omagari K, et al. Autoimmune reactivity of sera to hepatocyte plasma membrane in type I autoimmune hepatitis. J Gastroenterol 2000;35:226-34.
27. Mieli-Vergani G, Vergani D, Jenkins PJ, et al. Lymphocyte cytotoxicity to autologous hepatocytes in HBs Ag negative chronic active hepatitis. Clin Exp Immunol 1979;38:16-21.
28. Galle PR. Apoptosis in liver disease. J Hepatol 1997;27:405-12.
29. Feldmann G. Liver apoptosis. J Hepatol 1997;26(suppl 2):1-11.
30. Arii S, Imamura M. Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury. J Hepatobiliary Pancreat Surg 2000;7:40-8.
31. Jiang Z, Liu Y, Savas L, et of Frequency and distribution of DNA fragmentation as a marker of cell death in chronic liver diseases. Virchows Arch 1997;431:189-94.
32. + T cells within the liver. J Immunol 2001;166:5430-38.
33. + T cells by the normal liver. J Immunol 1999;163:3202-10.
34. Agrati C, Nisi C, Oliva A, et al. Lymphocyte distribution and intrahepatic compartmentalization during HCV infection: a main role for MHC-unrestricted T cells. Arch Immunol Ther Exp 2002;50:307-16.
35. Crotta S, Stilla A, Wack A, et al. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med 2002;195:35-41.