Immunological liver diseases in children

Seminars in Liver Disease

Volumn 18, Issue 3, 1998, Pages 271-279

  Mieli Vergani, Giorgina ^a   Vergani, Diego ^b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Autoimmune hepatitis; Immunosuppression; Liver transplant; Sclerosing cholangitis

Indexed keywords

ALCOHOL DEHYDROGENASE; ANTINUCLEAR ANTIBODY; AZATHIOPRINE; CYCLOSPORIN A; INTERLEUKIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PREDNISOLONE; SMOOTH MUSCLE ANTIBODY; TACROLIMUS; TUMOR NECROSIS FACTOR; URSODEOXYCHOLIC ACID;

ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; AUTOIMMUNE HEPATITIS; CLINICAL FEATURE; GENETIC PREDISPOSITION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; PORTAL HYPERTENSION; PRIORITY JOURNAL; REVIEW; SCLEROSING CHOLANGITIS; T LYMPHOCYTE;

EID: 0031713987     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007163     Document Type: Review

References (49)

1. Johnson PJ, McFarlane IG. Meeting report: international autoimmune hepatitis group. Hepatology 1993;18:998-1005
2. Johnson GD, Holborow EJ, Glynn LE. Antibody to smooth muscle in patients with liver disease. Lancet 1965;2:878-879
3. Manns MP, Griffin KJ, Sullivan KF, et al. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase. J Clin Invest 1991;88:1370-1378
4. Maggiore G, Veber F, Bernard O, et al. Autoimmune hepatitis associated with anti-actin antibodies in children and adolescents. J Pediatr Gastroenterol Nutr 1993;17:376-381
5. Gregorio G, Portmann B, Reid F, et al. Autoimmune hepatitis in childhood: a 20-year experience. Hepatology 1997;25:541-547
6. Homberg JC, Abuaf N, Bernard O, et al. Chronic active hepatitis associated with anti liver/kidney microsome antibody type 1: a second type of "autoimmune" hepatitis. Hepatology 1987;7: 333-1339
7. Vergani D, Wells L, Larcher VF, et al. Genetically determined low C4: a predisposing factor to autoimmune chronic active hepatitis. Lancet 1985;2:294-298
8. Doherty D, Underhill JA, Donaldson PT, et al. Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis. Autoimmunity 1994;18:243-249
9. Lachman PJ, Peters DK. Complement. In: Lachman PJ, Peters DK (eds): Clinical aspects of immunology. Oxford, Blackwell, 1982: pp 18-49
10. De Groote J, Desmet, VJ, Gedigk P, et al. A classification of chronic hepatitis. Lancet 1968;2:626
11. Scheuer PJ. Chronic Aggressive hepatitis. In: Liver biopsy interpretation. 2nd ed. Ballière Tindall 1974;68
12. Nouri-Aria K, Lobo Yeo A, Vergani D, et al. T suppressor cell function and number in children with liver disease. Clin Exp Immunol 1985;61:283-289
13. Nouri-Aria KT, Donaldson PT, Hegarty JE, et al. A1-B8-DR3 and suppressor cell function in first degree relative of patients with autoimmune chronic active hepatitis. J Hepatol 1985;1:235-241
14. Nouri-Aria KT, Hegarty JE, Alexander GJ, et al. Effect of corticosteroids on suppressor cell activity in "autoimmune" and viral chronic active hepatitis. New Engl J Med 1982;307:1301-1304
15. Donaldson PT, Doherty DG, Hayllar KM, McFarlane IG, Johnson PJ, Williams R. Susceptibility to autoimmune chronic active hepatitis: Human Leukocyte Antigens DR4 and A1-B8-DR3 are independent risk factors. Hepatology 1991;13:701-706
16. Vento S, Hegarty JE, Bottazzo G, et al. Antigen specific suppressor cell function in autoimmune chronic active hepatitis. Lancet 1984;1:1200-1204
17. Lobo-Yeo A, Senaldi G, Portmann P, et al. Class I and class II major histocompatibility complex antigen expression on hepatocytes. A study in children with liver disease. Hepatology 1990, 12:224-232
18. Lobo-Yeo A, Alviggi L, Mieli-Vergani G, et al. Preferential activation of helper/inducer T lymphocytes in children with autoimmune chronic active hepatitis. Clin Exp Immunol 1987;67:95-104
19. Senaldi G, Portmann B, Mowat AP, et al. Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis of childhood. Arch Dis Child 1992;67: 1447-1453
20. Vento S, Cainelli F, Renzini C, Concia E. Autoimmune hepatitis type 2 induced by HCV and persisting after viral clearance [Letter] Lancet 1997;350:1298
21. Choudhuri K, Gregorio GV, Mieli-Vergani G, Vergani D. T lymphocytes and autoimmunity in vival hepatitis: on the role of molecular mimicry. In Rizetto M, Purcell RH, Gerin JL, Verme G (eds): Viral Hepatitis and Liver Disease. Minerva Mediza, Turin, Italy, 1997, pp 424-427.
22. Jensen DM, McFarlane IG, Portmann B, et al. Detection of antibodies directed against a liver-specific lipoprotein in patients with acute and chronic active hepatitis. New Engl J Med 1978;299:1-7
23. McFarlane BM, McSorley CG, Vergani D, et al Serum antibodies reacting with the hepatic asialoglycoprotein receptor (hepatic lectin) in acute and chronic liver disorders. J Hepatol 1986;196-205
24. Ma Y, Gaken J, McFarlane BM, et al. Alcohol dehydrogenase: a target of humoral autoimmune response in liver disease. Gastroenterology 1997;112:483-492
25. Vergani D, Mieli-Vergani G, Mondelli M, et al. Immunoglobulin on the surface of isolated hepatocytes is associated with antibody-dependent cell-mediated cytotoxicity and liver damage. Liver 1987;7:307-15
26. Mieli-Vergani G, Vergani D, Jenkins PJ, et al. Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg negative chronic active hepatitis. Clin Exp Immunol 1979;38:16-21
27. Wen L, Peakman M, Mowat AP, et al. γδ+ T cell clones from liver biopsies of children with autoimmune chronic active hepatitis (aCAH) and primary sclerosing cholangitis (aPSC) are cytotoxic to human liver target cells [Abstract]. J Hepatol 1991;13:S80
28. Hussain MJ, Mowat AP, Mieli-Vergani G, et al. Circulating levels of interleukin 1α, tumour necrosis factor, interferon γ and soluble interleukin-2 receptor are high in children with autoimmune chronic liver disease [Abstract]. Hepatology 1990;12:937
29. Hussain MJ, Mustafa A, Gallati H, et al. Cellular expression of tumour necrosis factor-αand interferon-γ in the liver biopsies of children with chronic liver disease. J Hepatol 1994;21:816-821
30. Wen L, Peakman M, Lobo-Yeo A, et al. T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. Lancet 1990;336:1527-1530
31. Löhr H, Manns M, Kyriatsoulis A, et al. Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis. Clin Exp Immunol 1991;84: 297-302
32. Löhr H, Treichel U, Poralla T, et al. Liver-infiltrating T helper cells in autoimmune chronic active hepatitis stimulate the production of autoantibodies against the human asialoglycoprotein receptor in vitro. Clin Exp Immunol 1992;88:45-49
33. Maggiore G, Bernard O, Hadchouel M, Alagilee D. Life-saving immunosuppressive treatment in severe autoimmune chronic active hepatitis. J Pediatr Gastroenterol Nutr 1985;4:655-658
34. Debray D, Maggiore G, Bernard O. Cyclosporin treatment of autoimmune hepatitis (AIH) in children [Abstract]. J Pediatr Gastoenterol Nutr 1995;20:470
35. Johnson PJ, McFarlane IG, Williams R. Azathioprine for long term remission in autoimmune hepatitis. New Engl J Med 1995; 333:958-963
36. Gohlke F, Lohse AW, Dienes HP, et al. Evidence of an overlap syndrome of autoimmune hepatitis and primary sclerosing cholangitis. J Hepatol 1996;24:699-705
37. El-Shabrawi M, Wilkinson M, Portmann B, et al. Primary sclerosing cholangitis in childhood. Gastroenterology 1987;92: 1226-1235
38. Wilchanski M, Chait P, Wade JA, et al Primary sclerosing cholangitis in 32 children: clinical, laboratory and radiographic features with survival analysis. Hepatology 1995;22:1415-1422
39. Gregorio GV, Portmann B, Karani J, Vergani D, Mieli-Vergani G. Autoimmune sclerosing cholangitis: a distinct subset of childhood autoimmune liver disease [Abstract]. Hepatology 1996,24:170A
40. Mieli-Vergani G, Lobo-Yeo A, McFarlane BM, et al. Different immune mechanisms leading to autoimmunity in primary sclerosing cholangitis and autoimmune chronic active hepatitis of childhood. Hepatology 1989;9:98-203
41. Beuers U, Spengler U, Kruis W, et al. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo-controlled trial. Hepatology 1992;16:707-714
42. Lindor KD for the Mayo Primary Sclerosing Cholangitis - Ursodeoxycholic Acid Study Group. Ursodiol for primary sclerosing cholangitis. New Engl J Med 1997;336:691-694
43. Debray D, Pariente D, Urvoas E, Hadchouel M, Bernard O. Sclerosing cholangitis in children. J Pediatr 1994;124:49-56
44. Kerkar N, Hadžić N, Davies ET, et al. De novo 'autoimmune' hepatitis after liver transplantation. Lancet 1998;351:409-413
45. Pat BR, Xiao YX, Jimin L, Guo QH. Cyclosporin A-induced autoimmune disease in mice J Immunol 1993;151:39-50
46. Hess AD, Fischer AC, Horwitz LR, Laulis MK. Cyclosporine-induced autoimmunity: critical role of autoregulation in the prevention of major histocompatibility class II-dependent autoaggression. Transplant Proc 1993;25:2811-2813
47. Cooper MH, Hartmann GG, Starzl TE, Fung JJ. The induction of pseudo-graft-versus-host disease following syngenic bone marrow transplantation using FK 506. Transplant Proc 1991;23: 3234-3235
48. Hernandez Albujar A, Alvarez E, Salcedo M, et al. Autoimmune mediated liver disease after liver transplantation [Abstract]. J Hepatol 1997 Suppl:26:152
49. Conti F, Dousset B, Levillayer H, Gruska J, Weill B, Calmus Y. Autoantibodies after liver transplantation: a marker of allograft disease [Abstract]. J Hepatol 1997 Suppl;26.150