Prostacyclin in the cardiovascular system: New aspects and open questions

Pharmacological Reports

Volumn 57, Issue SUPPL., 2005, Pages 120-126

  Klumpp, Georg ^a   Schildknecht, Stefan ^a   Nastainczyk, Wolfgang ^b   Ullrich, Volker ^a   Bachschmid, Markus ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Cardiomyocyte; Cyclooxygenase; Endothelium; Nitration; Nitric oxide; Peroxynitrite; Prostacyclin synthase; Smooth muscle

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LIPOPOLYSACCHARIDE; PEROXYNITRITE; PROSTACYCLIN SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG TARGETING; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME SYNTHESIS; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE STEADY POTENTIAL; NITRATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; VALIDATION STUDY; VASCULAR ENDOTHELIUM;

EID: 33645671210     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Adam-Vizi V: Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. Antioxid Redox Signal, 2005, 7, 1140-1149.
2. Adderley SR, Fitzgerald DJ: Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. J Biol Chem, 1999, 274, 5038-5946.
3. Bachschmid M, Thurau S, Zou MH, Ullrich V: Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation. FASEB J, 2003, 17, 914-916.
4. Caughey GE, Cleland LG, Penglis PS, Gamble JR, James MJ: Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2. J Immunol, 2001, 167, 2831-2838.
5. de Deckere EA, Nugteren DH, Ten Hoor F: Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart. Nature, 1977, 268, 160-163.
6. DeWitt DL, Day JS, Sonnenburg WK, Smith WL: Concentrations of prostaglandin endoperoxide synthase and prostaglandin 12 synthase in the endothelium and smooth muscle of bovine aorta. J Clin Invest, 1983, 72, 1882-1888.
7. Griendling KK: Novel NAD(P)H oxidases in the cardiovascular system. Heart, 2004, 90, 491-493.
8. Inoue H, Taba Y, Miwa Y, Yokota C, Miyagi M, Sasaguri T: Transcriptional and posttranscriptional regulation of cyclooxygenase-2 expression by fluid shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol, 2002, 22, 1415-1420.
9. Krotz F, Schiele TM, Klauss V, Sohn HY: Selective COX-2 inhibitors and risk of myocardial infarction. J Vasc Res, 2005, 42, 312-324.
10. Kulmacz RJ, Wang LH: Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2. J Biol Chem, 1995, 270, 24019-24023.
11. Liou JY, Shyue SK, Tsai MJ, Chung CL, Chu KY, Wu KK: Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbolester-induced PGHS-2 in cultured endothelial cells. J Biol Chem, 2000, 275, 15314-15320.
12. Matsumura K, Cao C, Ozaki M, Morii H, Nakadate K, Watanabe Y: Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies. J Neurosci, 1998, 18, 6279-6289.
13. McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci USA, 1999, 96, 272-277.
14. Parks DA, Granger DN: Xanthine oxidase: biochemistry, distribution and physiology. Acta Physiol Scand Suppl, 1986, 548, 87-99.
15. Peng T, Lu X, Feng Q: NADH oxidase signaling induces cyclooxygenase-2 expression during lipopolysaccharide stimulation in cardiomyocytes. FASEB J, 2005, 19, 293-295.
16. Schildknecht S, Bachschmid M, Ullrich V: Peroxynitrite provides the peroxide tone for PGHS-2-dependent prostacyclin synthesis in vascular smooth muscle cells. FASEB J, 2005, 19, 1169-1171.
17. Schildknecht S, Bachschmid M, Baumann A, Ullrich V. COX-2 inhibitors selectively block prostacyclin synthesis in endotoxin-exposed vascular smooth muscle cells. FASEB J, 2004, 18, 757-759.
18. Stuehr D, Pou S, Rosen GM: Oxygen reduction by nitric-oxide synthases. J Biol Chem, 2001, 276, 14533-14536.
19. van der Loo B, Labugger R, Skepper JN, Bachschmid M, Kilo J, Powell JM, Palacios-Callender M et al.: Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med, 2000, 192, 1731-1744.
20. Zou MH, Ullrich V. Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inbibits bovine aortic prostacyclin synthase. FEBS Lett, 1996, 382, 101-104.