Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae

Biochemistry

Volumn 45, Issue 14, 2006, Pages 4491-4501

  Galdiero, Stefania ^a   Vitiello, Mariateresa ^a   Amodeo, Pietro ^b   D'Isanto, Marina ^a   Cantisani, Marco ^a   Pedone, Carlo ^a   Galdiero, Massimiliano ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOTECHNOLOGY; CYTOLOGY; ENZYMES;

BIOINFORMATICS ANALYSIS; INFLAMMATORY CYTOKINES; STRUCTURAL EXPLANATION; SYNTHETIC PEPTIDES;

MOLECULAR DYNAMICS;

ALANINE; AMINO ACID; CHEMOKINE; CYCLOPEPTIDE; CYTOKINE; GLYCINE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PORIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL INFECTION; BACTERIAL MEMBRANE; BIOINFORMATICS; CIRCULAR DICHROISM; CYTOKINE RELEASE; ENZYME ACTIVATION; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; HUMAN CELL; INFLAMMATION; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; COMPUTER SIMULATION; HAEMOPHILUS INFLUENZAE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; PORINS; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE; HAEMOPHILUS INFLUENZAE SEROTYPE B;

EID: 33645658734     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052262p     Document Type: Article

References (40)

1. Dufrene, Y. F. (2004) Using nanotechniques to explore microbial surfaces, Nat. Rev. Microbiol. 2, 451-460.
2. Achouak, W., Heulin, T., and Pages, J. M. (2001) Multiple facets of bacterial porins, FEMS Microbiol. Lett. 199, 1-7.
3. Galdiero, M., Cipollaro de l'Ero, G., Donnarumma, G., Marcatili, A., and Galdiero, F. (1995) Interleukin-1 and interleukin-6 gene expression in human monocytes stimulated with Salmonella typhimurium porins, Immunology 86, 612-619.
4. Galdiero, M., De Martino, L., Marcatili, A., Nuzzo, I., Vitiello, M., and Cipollaro de l'Ero, G. (1998) Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins, Immunology 94, 5-13.
5. Yi, K., and Murphy, T. F. (1997) Importance of an immunodominant surface-exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae, Infect. Immun. 65, 150-155.
6. Sikkema, D. J., and Murphy, T. F. (1992) Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae, Infect. Immun. 60, 5204-5211.
7. Bell, J., Grass, S., Jeanteur, D., and Munson, R. S., Jr. (1994) Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates, Infect. Immun. 62, 2639-2643.
8. Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., and Galdiero, M. (2003) Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade, Infect. Immun. 71, 2798-2809.
9. Srikumar, R., Dahan, D., Gras, M. F., Ratcliffe, M. J., van Alphen, L., and Coulton, J. W. (1992) Antigenic sites on porin of Haemophilus influenzae type b: mapping with synthetic peptides and evaluation of structure predictions, J. Bacteriol. 174, 4007-4016.
10. Saint, N., Lou, K. L., Widmer, C., Luckey, M., Schirmer, T., and Rosenbusch, J. P. (1996) Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization, J. Biol. Chem. 271, 20676-20680.
11. Dinarello, C. A. (1991) The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome, J. Infect. Dis. 163, 1177-1184.
12. Van Snick, J. (1990) Interleukin-6: an overview, Annu. Rev. Immunol. 8, 253-278.
13. Van Amersfoort, E. S., Van Berkel, T. J., and Kuiper, J. (2003) Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock, Clin. Microbiol. Rev. 16, 379-414.
14. Galdiero, M., Tortora, A., Damiano, N., Vitiello, M., Longanella, A., and Galdiero, E. (2005) Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways, Med. Microbiol. Immunol. 194, 13-23.
15. Rawadi, G., and Dussurget, O. (1995) Advances in PCR-based detection of mycoplasmas contaminating cell cultures, PCR Methods Appl. 4, 199-208.
16. Coulton, J. W., and Wan, I. F. (1983) The outer membrane of Haemophilus influenzae type b: cell envelope associations of major proteins, Can. J. Microbiol. 29, 280-287.
17. Galdiero, M., D'Amico, M., Gorga, F., Di Filippo, C., D'Isanto, M., Vitiello, M., Longanella, A., and Tortora, A. (2001) Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain, Infect. Immun. 69, 221-227.
18. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Polin phenol reagent, J. Biol. Chem. 193, 265-275.
19. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 277, 680-685.
20. Tsai, C. M., and Frasch, C. E. (1982) A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels, Anal. Biochem. 119, 115-119.
21. Yin, E. T., Galanos, C., Kinsky, S., Bradshaw, R. A., Wessler, S., Luderity, O., and Sarmiento, M. F. (1972) Picogram-sensitive assay for endotoxin: gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria, Biochim. Blophys. Acta 261, 284-289.
22. Nikaido, H., and Rosenberg, E. Y. (1983) Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins, J. Bacteriol. 153, 241-252.
23. Bonny, C., Oberson, A., Negri, S., Sauser, C., and Schorderet, D. F. (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death, Diabetes 50, 77-82.
24. Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Yang, P. R., and Lee, J. C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1, FEBS Lett. 364, 229-233.
25. Singh, J., Chuaqui, C. E., Boriack-Sjodin, P. A., Lee, W. C., Pontz, T., Corbley, M. J., Cheung, H. K., Arduini, R. M., Mead, J. N., Newman, M. N., Papadatos, J. L., Bowes, S., Josiah, S., and Ling, L. E. (2003) Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI), Bioorg. Med. Chem. Lett. 13, 4355-4359.
26. Chakrabartty, A., Kortemme, T., and Baldwin, R. L. (1994) Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions, Protein Sci. 3, 843-852.
27. Simmerling, C. L., Darden, T. A., Merz, K. M., Stanton, R. V., Cheng, A. L., Vincent, J. J., Crowley, M., Tsui, V., Radmer, R., Duan, Y., et al. (1999) AMBER 6, University of California, San Francisco, CA.
28. Koradi, R., Billeter, M., and Wüthrich, K. (1996) MOLMOL: a program for display and analysis of macromolecular structures, J. Mol. Graphics 14, 51-55.
29. Altschul, S. F., Madden, T. L., Schäffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res. 25, 3389-3402.
30. Cornell, W. D., Cieplak, P., Bayly, C. I., Gould, I. R., Merz, K. M., Jr., Ferguson, D. M., Spellmeyer, D. C., Fox, T., Caldwell, J. W., and Kollman, P. A. (1995) A second generation force field for the simulation of proteins, nucleic acids, and organic molecules, J. Am. Chem. Soc. 117, 5179-5197.
31. Saviano, G., Benedetti, E., Cozzolino, R., De Capua, A., Laccetti, P., Palladino, P., Zanotti, G., Amodeo, P., Tancredi, T., and Rossi, F. (2004) Influence of conformational flexibility on biological activity in cyclic astin analogues, Biopolymers 76, 477-484.
32. Jorgensen, W. L., Chandrasekhar, J., Madura, J., and Klein, M. L. (1983) Comparison of simple potential functions for simulating liquid water, J. Chem. Phys. 79, 926-935.
33. Vitale, R. M., Zaccaro, L., Di Blasio, B., Fattorusso, R., Isernia, C., Amodeo, P., Pedone, C., and Saviano, M. (2003) Conformational features of human melanin-concentrating hormone: an NMR and computational analysis, ChemBioChem 4, 73-81.
34. Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., and Bourne, P. E. (2000) The protein data bank, Nucleic Acids Res. 28, 235-242.
35. Hutchinson, E. G., and Thornton, J. M. (1994) A revised set of potentials for beta-turn formation in proteins, Protein Sci. 3, 2207-2216.
36. Abad-Zapatero, C., Goldman, R., Muchmore, S. W., Hutchins, C., Stewart, K., Navaza, J., Payne, C. D., and Ray, T. L. (1996) Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents, Protein Sci. 5, 640-652.
37. Li, S., Kelly, S. J., Lamani, E., Ferraroni, M., and Jedrzejas, M. J. (2000) Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase, EMBO J. 19, 1228-1240.
38. Singh, S. K., Matsuno, K., LaPorte, D. C., and Banaszak, L. J. (2001) Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 Å. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase, J. Biol. Chem. 276, 26154-26163.
39. Muller, D. J., and Engel, A. (1999) Voltage and pH-induced channel closure of porin OmpF visualized by atomic force microscopy, J. Mol. Biol. 285, 1347-1351.
40. Massari, P., Ram, S., Macleod, H., and Wetzler, L. M. (2003) The role of porins in neisserial pathogenesis and immunity, Trends Microbiol. 11, 87-93.