메뉴 건너뛰기




Volumn 41, Issue 3, 2006, Pages 130-141

Incretin hormones in the treatment of type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 AMINO 1 [5,6,7,8 TETRAHYDRO 3 (TRIFLUOROMETHYL) 1,2,4 TRIAZOLO[4,3 A]PYRAZIN 7 YL] 4 (2,4,5 TRIFLUOROPHENYL) 1 BUTANONE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; BIGUANIDE DERIVATIVE; CJC 1131; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; HEMOGLOBIN A1C; INCRETIN; INSULIN; INSULIN GLARGINE; LIRAGLUTIDE; METFORMIN; MIGLITOL; NATEGLINIDE; NEW DRUG; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; PLACEBO; REPAGLINIDE; ROSIGLITAZONE; SULFONYLUREA DERIVATIVE; UNINDEXED DRUG; VILDAGLIPTIN;

EID: 33645576200     PISSN: 1082801X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (42)
  • 1
    • 79960614571 scopus 로고    scopus 로고
    • American Diabetes Association. National Diabetes Fact Sheet. Available at http://www. diabetes.org/diabetes-statistics/national-diabetes-fact-sheet.jsp. Accessed February 27, 2006.
    • National Diabetes Fact Sheet
  • 2
    • 0021636730 scopus 로고
    • Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus
    • Ward WK, Beard JC, Halter JB, et al. Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes Care. 1984;7:491-502.
    • (1984) Diabetes Care , vol.7 , pp. 491-502
    • Ward, W.K.1    Beard, J.C.2    Halter, J.B.3
  • 3
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in subjects with type 2 diabetes (UKPDS 33)
    • UKPDS Group. Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in subjects with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 4
    • 11844259382 scopus 로고    scopus 로고
    • Standards of medical care in diabetes
    • American Diabetes Association. Standards of medical care in diabetes. Diabetes Care. 2005;28:S4-S36.
    • (2005) Diabetes Care , vol.28
  • 5
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of type 2 diabetes; a progressive disease (UKPDS 16)
    • UKPDS Group. Overview of 6 years' therapy of type 2 diabetes; a progressive disease (UKPDS 16). Diabetes. 1995;44:1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 6
    • 0014188893 scopus 로고
    • Plasma insulin responses to oral and intravenous glucose: Studies in normal and diabetic subjects
    • Perley M, Kipnis DM. Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest. 1967;46:1954-1962.
    • (1967) J Clin Invest , vol.46 , pp. 1954-1962
    • Perley, M.1    Kipnis, D.M.2
  • 7
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care. 2003;26:2929-2940.
    • (2003) Diabetes Care , vol.26 , pp. 2929-2940
    • Drucker, D.J.1
  • 8
    • 9444257639 scopus 로고    scopus 로고
    • The incretin approach for diabetes treatment: Modulation of islet hormone release by GLP-1 agonism
    • Holst JJ, Orskov C. The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism. Diabetes. 2004;53 (suppl 3):S197-S204.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Holst, J.J.1    Orskov, C.2
  • 9
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen MB, Damholt MB, Madsbad S, et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab. 2001;86:3717-3723.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 10
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, et al. Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993;36:741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3
  • 11
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone response, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone response, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab. 2002;87:1239-1246.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 12
    • 4344675057 scopus 로고    scopus 로고
    • Therapeutic strategies based on glucagons-like peptide 1
    • Deacon CF. Therapeutic strategies based on glucagons-like peptide 1. Diabetes. 2004;53:2181-2189.
    • (2004) Diabetes , vol.53 , pp. 2181-2189
    • Deacon, C.F.1
  • 13
    • 0037045845 scopus 로고    scopus 로고
    • Effect of a 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of a 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet. 2002;359:824-830.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 14
    • 16244409838 scopus 로고    scopus 로고
    • Exenatide: A novel incretin mimetic hormone for the treatment of type 2 diabetes
    • Gryskiewicz KA, Coleman CI. Exenatide: a novel incretin mimetic hormone for the treatment of type 2 diabetes. Formulary. 2005;40:86-90.
    • (2005) Formulary , vol.40 , pp. 86-90
    • Gryskiewicz, K.A.1    Coleman, C.I.2
  • 15
    • 0034814047 scopus 로고    scopus 로고
    • Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
    • Edward CM, Stanley SA, Davis R, et al. Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am J Physiol. 2001;281:E155-E161.
    • (2001) Am J Physiol , vol.281
    • Edward, C.M.1    Stanley, S.A.2    Davis, R.3
  • 16
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4; studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young AA, Gedulin BR, Bhavsar S, et al. Glucose-lowering and insulin-sensitizing actions of exendin-4; studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes. 1999;48:1026-1034.
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3
  • 17
    • 0035340019 scopus 로고    scopus 로고
    • Insulinotropic actions of exendin-4 and glucagons-like peptide-1 in vivo and in vitro
    • Parkes DG, Pittner R, Jodka C, et al. Insulinotropic actions of exendin-4 and glucagons-like peptide-1 in vivo and in vitro. Metabolism. 2001;50:S83-589.
    • (2001) Metabolism , vol.50
    • Parkes, D.G.1    Pittner, R.2    Jodka, C.3
  • 18
    • 0036965113 scopus 로고    scopus 로고
    • The insulinotropic effect of acute exendin-4 administered to humans: Comparison of nondiabetic state to type 2 diabetes
    • Egan JM, Clocquet AR, Elahi D. The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes. J Clin Endocrinol Metab. 2002;87:1282-1290.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1282-1290
    • Egan, J.M.1    Clocquet, A.R.2    Elahi, D.3
  • 19
    • 0037570392 scopus 로고    scopus 로고
    • Exendin-4 (AC2993) decreased glucagons secretion during hyperglycemic clamps in diabetic fatty Zucker rats
    • Gedulin B, Jodka C, Hoyt J. Exendin-4 (AC2993) decreased glucagons secretion during hyperglycemic clamps in diabetic fatty Zucker rats (abstract). Diabetes. 1999;48 (suppl 1):A199.
    • (1999) Diabetes , vol.48 , Issue.SUPPL. 1
    • Gedulin, B.1    Jodka, C.2    Hoyt, J.3
  • 20
    • 0005390777 scopus 로고    scopus 로고
    • Exendin-4 potentially regulates gastric emptying in rats
    • Jodka C, Gedulin B,Young A. Exendin-4 potentially regulates gastric emptying in rats (abstract). Diabetes. 1998;47 (suppl 1):A403.
    • (1998) Diabetes , vol.47 , Issue.SUPPL. 1
    • Jodka, C.1    Gedulin, B.2    Young, A.3
  • 21
    • 27744541052 scopus 로고    scopus 로고
    • Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes
    • Fehse FC, Trautmann ME, Holst JJ, et al. Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab. 2005;90:5991-5997.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5991-5997
    • Fehse, F.C.1    Trautmann, M.E.2    Holst, J.J.3
  • 22
    • 34250829991 scopus 로고    scopus 로고
    • San Diego, Calif: Amylin Pharmaceuticals, Inc
    • Byetta [package insert]. San Diego, Calif: Amylin Pharmaceuticals, Inc; 2005.
    • (2005) Byetta [Package Insert]
  • 23
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
    • Fineman MS, Bicsak TA, Shen LZ, et al. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care. 2003;26:2370-2377.
    • (2003) Diabetes Care , vol.26 , pp. 2370-2377
    • Fineman, M.S.1    Bicsak, T.A.2    Shen, L.Z.3
  • 24
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • Defronzo RA, Ratner RE, Han J, et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2005;28:1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • Defronzo, R.A.1    Ratner, R.E.2    Han, J.3
  • 25
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27:2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3
  • 26
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care. 2005;28:1083-1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 27
    • 24944502062 scopus 로고    scopus 로고
    • 1c and weight over 82 weeks in overweight patients with type 2 diabetes
    • June 10-14; San Diego, Calif. Abstract 477-P
    • 1c and weight over 82 weeks in overweight patients with type 2 diabetes (abstract). Presented at: American Diabetes Association 65th Annual Scientific Sessions; June 10-14, 2005; San Diego, Calif. Abstract 477-P.
    • (2005) American Diabetes Association 65th Annual Scientific Sessions
    • Blonde, L.1    Han, J.2    Mac, S.3
  • 28
    • 33645001991 scopus 로고    scopus 로고
    • 1c and body weight in long-term trials are not explained by gastrointestinal side effects
    • June 10-14; San Diego, Calif. Abstract 485-P
    • 1c and body weight in long-term trials are not explained by gastrointestinal side effects (abstract). Presented at: American Diabetes Association 65th Annual Scientific Sessions; June 10-14, 2005; San Diego, Calif. Abstract 485-P.
    • (2005) American Diabetes Association 65th Annual Scientific Sessions
    • Maggs, D.1    Kirn, D.2    Holcombe, J.3
  • 29
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes
    • Heine RJ, Van Gall LF, Johns D, et al. Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes. Ann Intern Med. 2005;143:559-569.
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.J.1    Van Gall, L.F.2    Johns, D.3
  • 30
    • 2342599057 scopus 로고    scopus 로고
    • One week's treatment with the long-acting glucagons-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes
    • Degn KB, Juhl CB, Sturis J, et al. One week's treatment with the long-acting glucagons-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes. 2004;53:1187-1194.
    • (2004) Diabetes , vol.53 , pp. 1187-1194
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3
  • 31
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety, and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agerso H, Jensen LB, Elbrond B, et al. The pharmacokinetics, pharmacodynamics, safety, and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia. 2002;45:195-202.
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3
  • 32
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
    • Juhl CB, Hollingdal M, Sturis J, et al. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes. 2002;51:424-429.
    • (2002) Diabetes , vol.51 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3
  • 33
    • 2542451393 scopus 로고    scopus 로고
    • Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211)
    • Madsbad S, Schmitz O, Ranstam J, et al. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211). Diabetes Care. 2004;1335-1342.
    • (2004) Diabetes Care , pp. 1335-1342
    • Madsbad, S.1    Schmitz, O.2    Ranstam, J.3
  • 35
    • 34247481007 scopus 로고    scopus 로고
    • Effects of DAC-GLP:1 (CJC-1131) on glycemic control and weight over 12 weeks in metformin-treated patients with type 2 diabetes
    • June 10-14; San Diego, Calif. Abstract 10-OR
    • Ratner RE, Guivarc PH, Dreyfus JF, et al. Effects of DAC-GLP:1 (CJC-1131) on glycemic control and weight over 12 weeks in metformin-treated patients with type 2 diabetes (abstract). Presented at: American Diabetes Association 65th Annual Scientific Sessions; June 10-14, 2005; San Diego, Calif. Abstract 10-OR.
    • (2005) American Diabetes Association 65th Annual Scientific Sessions
    • Ratner, R.E.1    Guivarc, P.H.2    Dreyfus, J.F.3
  • 36
    • 4544344541 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor LAF237 improves glycemic control in patients with type 2 diabetes (T2DM)
    • June 4-8. Orlando, Fla. Abstract 355-OR
    • Pratley R, Galbreath E. Twelve-week monotherapy with the DPP-4 inhibitor LAF237 improves glycemic control in patients with type 2 diabetes (T2DM) (abstract). Presented at: American Diabetes Association 64th Annual Scientific Sessions; June 4-8, 2004. Orlando, Fla. Abstract 355-OR.
    • (2004) American Diabetes Association 64th Annual Scientific Sessions
    • Pratley, R.1    Galbreath, E.2
  • 37
    • 9444285818 scopus 로고    scopus 로고
    • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • Ahren B, Gomis R, Standl E, et al. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care. 2004;27:2874-2880.
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahren, B.1    Gomis, R.2    Standl, E.3
  • 38
    • 31144459380 scopus 로고    scopus 로고
    • Twelve-week efficacy and tolerability of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in the treatment of type 2 diabetes (T2D)
    • June 10-14; San Diego, Calif. Abstract 41-OR
    • Scott R, Herman G, Zhao P, et al. Twelve-week efficacy and tolerability of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in the treatment of type 2 diabetes (T2D). Presented at: American Diabetes Association 65th Annual Scientific Sessions; June 10-14, 2005; San Diego, Calif. Abstract 41-OR.
    • (2005) American Diabetes Association 65th Annual Scientific Sessions
    • Scott, R.1    Herman, G.2    Zhao, P.3
  • 39
    • 33845491342 scopus 로고    scopus 로고
    • Effect of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, on glycemic control after 12 weeks in patients with type 2 diabetes
    • June 10-14; San Diego, Calif. Abstract 541-P
    • Herman G, Hanefeld M, Wu M, et al. Effect of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, on glycemic control after 12 weeks in patients with type 2 diabetes. Presented at: American Diabetes Association 65th Annual Scientific Sessions; June 10-14, 2005; San Diego, Calif. Abstract 541-P.
    • (2005) American Diabetes Association 65th Annual Scientific Sessions
    • Herman, G.1    Hanefeld, M.2    Wu, M.3
  • 40
    • 27844493765 scopus 로고    scopus 로고
    • Effect of adding MK-0431 to on-going metformin therapy in type 2 diabetic patients who have inadequate glycemic control on metformin
    • June 10-14; San Diego, Calif. Abstract 11-OR
    • Brazg R, Thomas K, Zhao P, et al. Effect of adding MK-0431 to on-going metformin therapy in type 2 diabetic patients who have inadequate glycemic control on metformin. Presented at: American Diabetes Association 65th Annual Scientific Sessions; June 10-14, 2005; San Diego, Calif. Abstract 11-OR.
    • (2005) American Diabetes Association 65th Annual Scientific Sessions
    • Brazg, R.1    Thomas, K.2    Zhao, P.3
  • 41
    • 33645573333 scopus 로고    scopus 로고
    • First DataBank. Available at: http://www.first databank.com/. Accessed February 22, 2006.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.