The fate of axons subjected to traumatic ultrastructural (neurofilament) compaction: An electron-microscopic study

Acta Neuropathologica

Volumn 111, Issue 3, 2006, Pages 229-237

  Gallyas, Ferenc ^a   Pál, József ^a   Farkas, Orsolya ^a   Dóczi, Tamás ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Degeneration; Electron microscopy; Recovery; Regeneration

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXOPLASM; BRAIN INJURY; CELL FATE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; MYELIN SHEATH; MYELINATED NERVE; NEOCORTEX; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NERVE FIBER MEMBRANE; NERVE LESION; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SURVIVAL TIME;

ANIMALS; AXONS; CRANIOCEREBRAL TRAUMA; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN SHEATH; NERVE DEGENERATION; NEUROFIBRILS; RATS; RATS, WISTAR; SILVER;

EID: 33645557857     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-006-0034-3     Document Type: Article

References (22)

1. Adams JH, Graham DI, Gennarelli TA (1983) Head injury in man and experimental animals. Acta Neurochir 32(Suppl):15-30
2. Auer RN, Kalimo H, Olsson Y, Siesjö BK (1985) The temporal evolution of hypoglycemic brain damage. I. Light- and electron-microscopic findings in the rat cerebral cortex. Acta Neuropathol 67:13-24
3. Buki A, Siman R, Trojanovsky JQ, Povlishock JR (1999) The role of calpain mediated spectrin proteolysis in traumatically induced axonal injury. J Neuropathol Exp Neurol 58:365-375
4. Cammermeyer J (1961) The importance of avoiding "dark" neurons in experimental neuropathology. Acta Neuropathol 1:245-270
5. Christman CW, Salivan JB Jr, Walker SA, Povlishock JT (1997) Characterization of a prolonged regenerative attempt by diffusely injured axons following traumatic brain injury in adult cat: A light and electron microscopic immunocytochemical study. Acta Neuropathol 94:329-337
6. Csordás A, Mázló M, Gallyas F (2003) Recovery versus death of "dark" (compacted) neurons in non-impaired parenchymal environment. Acta Neuropathol 106:37-49
7. Elder GA, Friedrich VL Jr, Bosco P, Kang C, Gourov A, Tu PH, Lee VM, Lazzarini RA (1998) Absence of mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content. J Cell Biol 141:727-739
8. Gallyas F, Zoltay G (1992) An immediate light microscopic response of neuronal somata, dendrites and axons to non-contusing consussive head injury. Acta Neuropathol 83:386-393
9. Gallyas F, Hsu M, Buzsaki G (1993) Four modified silver methods for thick sections of formaldehyde-fixed mammalian central nervous tissue: "dark" neurons, perikarya of all neurons, microglial cells and capillaries. J Neurosci Meth 50:159-164
10. Gallyas F, Farkas O, Mázló M (2002) Traumatic compaction of the axonal cytoskeleton induces argyrophilia: Histological and theoretical importance. Acta Neuropathol 103:36-43
11. Gallyas F, Farkas O, Mázló M (2004) Whole-cell ultrastructural compaction ("dark" cell formation) in mammalian tissues may consist in gel-to-gel phase transition. Biol Cell 96:313-324
12. Graham DI, McIntosh TK, Maxwell WL, Nicoll JAR (2000) Recent advances in neurotrauma. J Neuropathol Exp Neurol 59:641-651
13. Hayat MA (1981) Fixation for electron microscopy Academic, New York, pp 88, 123, 212
14. Maxwell WL, Povlishock JT, Graham DL (1997) A mechanistic analysis of nondisruptive axonal injury: A review. J Neurotrauma 14:419-440
15. Narciso MS, Hokoc JN, Martinez AMB (2001) Watery and dark axons in Wallerian degeneration of the opossum's optic nerve: Different patterns of cytoskeletal breakdown? Ann Acad Bras Cienc 73:231-243
16. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates Academic, Sydney, New York, plates 18 and 19
17. Pál J, Tóth Zs, Farkas O, Kellényi L, Dóczi T, Gallyas F Selective induction of ultrastructural (neurofilament) compaction in axons by means of a new head injury apparatus. J Neurosci Meth (in press)
18. Pettus EH, Povlishock JT (1996) Characterization of a distinct set of intraaxonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability. Brain Res 722:1-11
19. Pettus EH, Christman CW, Giebel ML, Povlishock JT (1994) Traumatically induced altered membrane permeability: Its relationship to traumatically induced reactive axonal change. J Neurotrauma 11:507-552
20. Povlishock JT, Jenkins LW (1995) Are the pathobiological changes evoked by traumatic brain injury immediate and irreversible? Brain Pathol 5:415-426
21. Stone JR, Singleton RH, Povlishock JT (2001) Intraaxonal neurofilament compaction does not evoke local axonal swelling in all traumatically injured axons. Exp Neurol 172:320-331
22. Zsombok A, Tóth Zs, Gallyas F (2005) Basophilia, acidophilia and argyrophilia of "dark" (compacted) neurons in the course of their formation, recovery or death in an otherwise undamaged environment. J Neurosi Meth 142:145-152