Stabilization of the biologically active conformation of the principal neutralizing determinant of HIV-1IIIB containing a cis-proline surrogate: 1H NMR and molecular modeling study

Biochemistry

Volumn 45, Issue 13, 2006, Pages 4284-4294

  Garcia, Julian ^a   Dumy, Pascal ^a   Rosen, Osnat ^b   Anglister, Jacob ^b  

^a UNIVERSITÉ JOSEPH FOURIER   (France)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; IMMUNOLOGY; NUCLEAR MAGNETIC RESONANCE; PROTEINS; VIRUSES;

BIOLOGICAL PROCESSES; CIS-PROLINE SURROGATE; HUMAN IMMUNODEFICIENCY VIRUS (HIV-1); MOLECULAR MODELING;

DISEASE CONTROL;

GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PROLINE; SYNTHETIC PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; BINDING SITE; BIOAVAILABILITY; COMPLEX FORMATION; HOST RESISTANCE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; VIRUS ENVELOPE;

AMINO ACID SEQUENCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV ENVELOPE PROTEIN GP120; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROLINE; PROTEIN CONFORMATION; STEREOISOMERISM; THIAZOLES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33645547395     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052615k     Document Type: Article

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