메뉴 건너뛰기




Volumn 73, Issue 3, 2006, Pages 257-268

Aldosterone receptor antagonists for heart failure: Current status, future indications

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE; ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CANDESARTAN; CAPTOPRIL; CARVEDILOL; CLOPIDOGREL; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; EPLERENONE; LOOP DIURETIC AGENT; PLACEBO; POTASSIUM; SODIUM; SPIRONOLACTONE; THIAZIDE DIURETIC AGENT; VALSARTAN; ALDOSTERONE RECEPTOR; DRUG DERIVATIVE;

EID: 33645508990     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.73.3.257     Document Type: Review
Times cited : (12)

References (36)
  • 1
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • Valsartan Heart Failure Trial Investigators
    • Cohn JN, Tognoni G; Valsartan Heart Failure Trial Investigators. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 2001; 345:1667-1675.
    • (2001) N Engl J Med , vol.345 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 2
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial
    • CHARM Investigators and Committees
    • McMurray JJ, Ostergren J, Swedberg K, et al; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet 2003; 362:767-771.
    • (2003) Lancet , vol.362 , pp. 767-771
    • McMurray, J.J.1    Ostergren, J.2    Swedberg, K.3
  • 3
    • 28744446343 scopus 로고    scopus 로고
    • ACC/AHA guideline update for the diagnosis and management of chronic heart failure in the adult: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • American College of Cardiology; American Heart Association
    • Hunt SA, Baker DW, Chin MH, et al; American College of Cardiology; American Heart Association. ACC/AHA guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and management of heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 2005; 112:e154-235.
    • (2005) Circulation , vol.112
    • Hunt, S.A.1    Baker, D.W.2    Chin, M.H.3
  • 4
    • 0036668187 scopus 로고    scopus 로고
    • Mineralocorticoid receptors and pathophysiological roles for aldosterone in the cardiovascular system
    • Young MJ, Funder JW. Mineralocorticoid receptors and pathophysiological roles for aldosterone in the cardiovascular system. J Hypertens 2002; 20:1465-1468.
    • (2002) J Hypertens , vol.20 , pp. 1465-1468
    • Young, M.J.1    Funder, J.W.2
  • 5
    • 0242608659 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade: New insights into the mechanism of action in patients with cardiovascular disease
    • Pitt B, Stier CT Jr, Rajagopalan S. Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease. J Renin Angiotensin Aldosterone Syst 2003; 4:164-168.
    • (2003) J Renin Angiotensin Aldosterone Syst , vol.4 , pp. 164-168
    • Pitt, B.1    Stier Jr., C.T.2    Rajagopalan, S.3
  • 6
    • 0035378358 scopus 로고    scopus 로고
    • Aldosterone antagonists in the treatment of hypertension and target organ damage
    • Rajagopalan S. Pitt B. Aldosterone antagonists in the treatment of hypertension and target organ damage. Curr Hypertens Rep 2001; 3:240-248.
    • (2001) Curr Hypertens Rep , vol.3 , pp. 240-248
    • Rajagopalan, S.1    Pitt, B.2
  • 7
    • 0033533456 scopus 로고    scopus 로고
    • Comparison of candesartan, enalapril, and their combination in congestive heart failure: Randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study
    • The RESOLVD Pilot Study Investigators
    • McKelvie RS, Yusuf S, Pericak D, et al. Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators. Circulation 1999; 100:1056-1064.
    • (1999) Circulation , vol.100 , pp. 1056-1064
    • McKelvie, R.S.1    Yusuf, S.2    Pericak, D.3
  • 8
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341:709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 9
    • 0037433183 scopus 로고    scopus 로고
    • Effects of initiating carvedilol in patients with severe chronic heart failure: Results from the COPERNICUS Study
    • Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Group
    • Krum H, Roecker EB, Mohacsi P, et al; Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Group. Effects of initiating carvedilol in patients with severe chronic heart failure: results from the COPERNICUS Study. JAMA 2003; 289:712-718.
    • (2003) JAMA , vol.289 , pp. 712-718
    • Krum, H.1    Roecker, E.B.2    Mohacsi, P.3
  • 10
    • 20544453277 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic heart failure: Executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic heart Failure of the European Society of Cardiology
    • Task Force for the Diagnosis and Treatment of Chronic heart Failure of the European Society of Cardiology
    • Swedberg K, Cleland J, Dargie H, et al; Task Force for the Diagnosis and Treatment of Chronic heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): the Task Force for the Diagnosis and Treatment of Chronic heart Failure of the European Society of Cardiology. Eur Heart J 2005; 26:1115-1140.
    • (2005) Eur Heart J , vol.26 , pp. 1115-1140
    • Swedberg, K.1    Cleland, J.2    Dargie, H.3
  • 11
    • 0037125404 scopus 로고    scopus 로고
    • Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure
    • Cicoira M, Zanolla L, Rossi A, et al. Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol 2002; 40:304-310.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 304-310
    • Cicoira, M.1    Zanolla, L.2    Rossi, A.3
  • 12
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: Insights from the Randomized Aldactone Evaluation Study (RALES)
    • RALES Investigators
    • Zannad F, Alla F, Dousset B, Perez A, Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the Randomized Aldactone Evaluation Study (RALES). RALES Investigators. Circulation 2000; 102:2700-2706.
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 13
    • 0030870613 scopus 로고    scopus 로고
    • Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients
    • MacFadyen RJ, Barr CS. Struthers AD. Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients. Cardiovasc Res 1997; 35:30-34.
    • (1997) Cardiovasc Res , vol.35 , pp. 30-34
    • MacFadyen, R.J.1    Barr, C.S.2    Struthers, A.D.3
  • 14
    • 0035370038 scopus 로고    scopus 로고
    • Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure
    • Yee KM, Pringle SD, Struthers AD. Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure. J Am Coll Cardiol 2001; 37:1800-1807.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1800-1807
    • Yee, K.M.1    Pringle, S.D.2    Struthers, A.D.3
  • 15
    • 0034651798 scopus 로고    scopus 로고
    • Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I /angiotensin II conversion in patients with chronic heart failure
    • Farquharson CA, Struthers AD. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure. Circulation 2000; 101:594-597.
    • (2000) Circulation , vol.101 , pp. 594-597
    • Farquharson, C.A.1    Struthers, A.D.2
  • 16
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348:1309-1321.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 17
    • 4544327298 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction; a report of the American College of Cardiology /American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction)
    • Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction; a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). J Am Coll Cardiol 2004; 44:E1-E211.
    • (2004) J Am Coll Cardiol , vol.44
    • Antman, E.M.1    Anbe, D.T.2    Armstrong, P.W.3
  • 18
    • 20144367331 scopus 로고    scopus 로고
    • Cost-effectiveness of eplerenone compared with placebo in patients with myocardial infarction complicated by left ventricular dysfunction and heart failure
    • Weintraub WS, Zhang Z, Mahoney EM, et al. Cost-effectiveness of eplerenone compared with placebo in patients with myocardial infarction complicated by left ventricular dysfunction and heart failure. Circulation 2005; 111: 1106-1113
    • (2005) Circulation , vol.111 , pp. 1106-1113
    • Weintraub, W.S.1    Zhang, Z.2    Mahoney, E.M.3
  • 19
    • 22844437062 scopus 로고    scopus 로고
    • Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure
    • EPHESUS Investigators
    • Pitt B, White H, Martinez F, et al; EPHESUS Investigators. Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol 2005; 46:425-431.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 425-431
    • Pitt, B.1    White, H.2    Martinez, F.3
  • 20
    • 0034126414 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology
    • Delyani JA. Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int 2000; 57:1408-1411.
    • (2000) Kidney Int , vol.57 , pp. 1408-1411
    • Delyani, J.A.1
  • 21
    • 3442888821 scopus 로고    scopus 로고
    • Managing hyperkalemia caused by inhibitors of the renin-angiotensin-aldosterone system
    • Palmer BF. Managing hyperkalemia caused by inhibitors of the renin-angiotensin-aldosterone system. N Engl J Med 2004; 351:585-592.
    • (2004) N Engl J Med , vol.351 , pp. 585-592
    • Palmer, B.F.1
  • 22
    • 0035870772 scopus 로고    scopus 로고
    • Life-threatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: An analysis of 25 cases
    • Schepkens H, Vanholder R, Billiouw JM, Lameire N. Life-threatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: an analysis of 25 cases. Am J Med 2001; 110:438-441.
    • (2001) Am J Med , vol.110 , pp. 438-441
    • Schepkens, H.1    Vanholder, R.2    Billiouw, J.M.3    Lameire, N.4
  • 23
    • 3442886513 scopus 로고    scopus 로고
    • Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
    • Juurlink DN, Mamdani MM, Lee DS, et al. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 2004; 351:543-551.
    • (2004) N Engl J Med , vol.351 , pp. 543-551
    • Juurlink, D.N.1    Mamdani, M.M.2    Lee, D.S.3
  • 24
    • 0038526268 scopus 로고    scopus 로고
    • Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction
    • Hayashi M, Tsutamoto T, Wada A, et al. Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction. Circulation 2003; 107:2559-2565.
    • (2003) Circulation , vol.107 , pp. 2559-2565
    • Hayashi, M.1    Tsutamoto, T.2    Wada, A.3
  • 25
    • 0036841840 scopus 로고    scopus 로고
    • Aldosterone antagonist improves diastolic function in essential hypertension
    • Grandi AM, Imperiale D, Santillo R, et al. Aldosterone antagonist improves diastolic function in essential hypertension. Hypertension 2002; 40:647-652.
    • (2002) Hypertension , vol.40 , pp. 647-652
    • Grandi, A.M.1    Imperiale, D.2    Santillo, R.3
  • 26
    • 33646154830 scopus 로고    scopus 로고
    • Efficacy and safety of eplerenone, enalapril, and eplerenone/enalapril combination therapy for essential hypertension and left ventricular hypertrophy: The 4E Study
    • [abstract]. Atlanta, GA
    • Pitt B, Reichek N, Metscher B, et al. Efficacy and safety of eplerenone, enalapril, and eplerenone/enalapril combination therapy for essential hypertension and left ventricular hypertrophy: The 4E Study [abstract]. In: American College of Cardiology, Atlanta, GA; 2002.
    • (2002) American College of Cardiology
    • Pitt, B.1    Reichek, N.2    Metscher, B.3
  • 27
    • 0041408234 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial
    • Yusuf S, Pfeffer MA, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003; 362:772-776.
    • (2003) Lancet , vol.362 , pp. 772-776
    • Yusuf, S.1    Pfeffer, M.A.2    Swedberg, K.3
  • 28
    • 0032951417 scopus 로고    scopus 로고
    • Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension
    • Sato A, Suzuki Y, Saruta T. Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension. Hypertens Res 1999; 22:17-22.
    • (1999) Hypertens Res , vol.22 , pp. 17-22
    • Sato, A.1    Suzuki, Y.2    Saruta, T.3
  • 29
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study
    • Pitt B, Reichek N, Willenbrock R, et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003; 108:1831-1838.
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 30
    • 0142231538 scopus 로고    scopus 로고
    • Efficacy of low-dose spironolactone in subjects with resistant hypertension
    • Nishizaka MK, Zaman MA, Calhoun DA. Efficacy of low-dose spironolactone in subjects with resistant hypertension. Am J Hypertens 2003; 16:925-930.
    • (2003) Am J Hypertens , vol.16 , pp. 925-930
    • Nishizaka, M.K.1    Zaman, M.A.2    Calhoun, D.A.3
  • 31
    • 0037035471 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism in experimental atherosclerosis
    • Rajagopalan S, Duquaine D, King S, Pitt B, Patel P. Mineralocorticoid receptor antagonism in experimental atherosclerosis. Circulation 2002; 105:2212-2216.
    • (2002) Circulation , vol.105 , pp. 2212-2216
    • Rajagopalan, S.1    Duquaine, D.2    King, S.3    Pitt, B.4    Patel, P.5
  • 32
    • 0037780685 scopus 로고    scopus 로고
    • Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice
    • Keidar S, Hayek T, Kaplan M, et al. Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol 2003; 41:955-963.
    • (2003) J Cardiovasc Pharmacol , vol.41 , pp. 955-963
    • Keidar, S.1    Hayek, T.2    Kaplan, M.3
  • 33
    • 0034457808 scopus 로고    scopus 로고
    • Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production
    • Brown NJ, Kim KS, Chen YQ, et al. Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production. J Clin Endocrinol Metab 2000; 85:336-344.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 336-344
    • Brown, N.J.1    Kim, K.S.2    Chen, Y.Q.3
  • 34
    • 0036172321 scopus 로고    scopus 로고
    • Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans
    • Sawathiparnich P, Kumar S, Vaughan DE, Brown NJ. Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans. J Clin Endocrinol Metab 2002; 87:448-452.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 448-452
    • Sawathiparnich, P.1    Kumar, S.2    Vaughan, D.E.3    Brown, N.J.4
  • 35
    • 0035943051 scopus 로고    scopus 로고
    • Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries
    • Ward MR, Kanellakis P, Ramsey D, Funder J, Bobik A. Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries. Circulation 2001; 104:467-472.
    • (2001) Circulation , vol.104 , pp. 467-472
    • Ward, M.R.1    Kanellakis, P.2    Ramsey, D.3    Funder, J.4    Bobik, A.5
  • 36
    • 5444220823 scopus 로고    scopus 로고
    • Eplerenone: Will it have a role in the treatment of acute coronary syndromes?
    • Meier DJ, Pitt B, Rajagopalan S. Eplerenone: will it have a role in the treatment of acute coronary syndromes? Curr Cardiol Rep 2004; 6:259-263.
    • (2004) Curr Cardiol Rep , vol.6 , pp. 259-263
    • Meier, D.J.1    Pitt, B.2    Rajagopalan, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.