Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms

Acta Neurologica Scandinavica

Volumn 113, Issue 5, 2006, Pages 307-314

  Dikmen, M ^a   Ozbabalik, D ^a   Gunes, H V ^a   Degirmenci, I ^a   Bal, C ^a   Ozdemir, G ^a   Basaran, A ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

Author keywords

A1298C; C677T; Homocysteine; MTHFR; Polymorphism; Stroke

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CREATININE; CYANOCOBALAMIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HOMOCYSTINURIA; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; STROKE; SYSTOLIC BLOOD PRESSURE; TURKEY (REPUBLIC);

CASE-CONTROL STUDIES; CEREBROVASCULAR ACCIDENT; FEMALE; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 33645463321     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2005.00556.x     Document Type: Article

References (46)

1. R osenblatt DS. Methylenetetrahydrofolate reductase. Clin Invest Med 2001 24 56 59.
2. W eisberg I T ran P C hristensen B et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet and Metab 1998 64 169 72.
3. H omberger G L innebank M W inter C. Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene. Eur J Hum Genet 2000 8 725 9.
4. S tern LL B agley PJ R osenberg IH et al. Conversion of 5-formyltetrahydrofolic acid is unimpaired in folate-adequate persons homozygous for the C677T mutation in the methylenetetrahydrofolate reductase gene. J Nutr 2000 130 2238 42.
5. G oyette P R ozen R. The thermolabile variant 667CT can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase. Hum Mutat 2000 16 132 8.
6. R ady PL T yring SK H undnall SD et al. Methylenetetrahydrofolate reductase (MTHFR): the incidence of mutations C677T and A1298C in the Ashkenazi Jewish population. Am J Med Genet 1999 86 380 4.
7. F riedman G G oldschmidt N F riedlander Y et al. Common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. J Nutr 1999 129 1656 61
8. B otto LD Y ang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 2000 151 862 77.
9. N elen WLDM B lom HJ T homas CMG et al. Methylenetetrahydrofolate reductase polymorphism affects the charge in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. Nutr Org 1998 128 1336.
10. T an NC V enketasubramanian N S aw SM et al. Hyperhomocyst(e)inemia and risk of ischemic stroke among young Asian adults. Stroke 2002 33 1956 62.
11. G unes HV A ta N D eǧirmenci I et al. Frequency of angiotensin-converting enzyme gene polymorphism in Turkish hypertensive patients. Int J Clin Pract 2004 58 838 43.
12. F rosst P B lom RM G oyette P. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reeductase. Nat Genet 1995 10 111 3.
13. S kibola CF S mith MT K ane E et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Med Sci 1996 96 12810 5.
14. van der P ut NM G abreels F S tevens EMB et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects. Am J Hum Genet 1998 62 1044 51.
15. M orita H K urihara H T subaki q24 S et al. Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese. Arterioscl Thromb Vasc Biol 1998 18 1465 9.
16. A kar N A kar E A kçay R et al. Effect of methylenetetrahidrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients. Thromb Res 2000 97 163 7.
17. E ikelboom JW H ankey GJ A nand SS et al. Association between high homocyst(e)ine ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 2000 31 1069.
18. H armon DL D oyle RM M eleady R et al. Genetic analysis of the thermolabile variant of 5,10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke. Arterioscl Thromb Vasc Biol 1999 19 208 11.
19. M adonna P S tefano V C oppola A et al. Hyperhomocysteinemia and other inherited prothrombotic conditions in young adults with a history of ischemic stroke. Stroke 2002 33 51 56.
20. M ciiroy SP D ynan KB L awson JT et al. Moderatly elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and alzheimer disease in Northern Irland. Stroke 2002 33 2351 6
21. LEIDEN A1691G, methylenetetrahydrofolate reductase C677T, prothrombin G20210A mutation, and algorithms for venous thrombosis investigations. Clin Biochem 1999 32 223 8.
22. S utton -T yrrell K B ostom A S elhub J et al. High homocysteine levels are independently related to isolated systolic hypertension in older adults. Circulation 1997 96 1745 9.
23. B oushey CJ B eresford SA O menn GS et al. A quantitative as plasma homocysteine as a risk factor for vascular disease. JAMA 1995 274 1049 57.
24. S ucu M K aradere A T oprak N. Homosistein ve kardiyovasküler hastaliklari. Türk Kardiyol Dern Arş 2001 29 181 90.
25. G üleç S A ras Ö A kar E et al. Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction. Clin Cardiol 2001 24 281 4.
26. B ozkaya G Ç avuşoǧlu A B ilgili S et al. Homocysteine levels and other risk factors in coronary heart disease. Turk J Med Sci 2001 31 425 8.
27. K awamoto R K ohara K T abara Y. An association of 5,10- methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis. J Hum Genet 2001 46 506 10.
28. V erhoef P H ennekens CH M alinow MR et al. A prospective study of plasma homocyst(e)ine and risk of ischemic stroke. Stroke 1994 25 1924 30.
29. B ushnel CD G oldstein LB. Homocysteine testing in patients with acute ischemic stroke. Neurology 2002 59 1541 6.
30. K aye JM S tanton KG M ccann VJ et al. Homocysteine, folate, methylenetetrahydrofolate reductase genotype and vascular morbidity in diabetic subjects. Clin Sci 2002 102 631 7.
31. D rzewaski J C zupryniak L C hwatko G B ald E. Total plasma homocysteine and insuline levels in type 2 diabetic patients with secondary failure to oral agents. Diabetes Care 1999 22 2097 9.
32. S un J X u Y X ue J Z hu Y L u H. Methylenetetrahydrofolate reductase polymorphism associated with susceptibility to coronary heart disease in Chinese type 2 diabetic patients. Mol Cell Endocrinol 2005 229 95 101.
33. M azza A B ossone E M azza F D istante A. Reduced serum homocysteine levels in type 2 diabetes. Nutr Metabol Cardiovasc Dis 2005 15 118 24.
34. L aiouschek W A ull S S chnider P et al. Genetic and nongenetic factors influencing plasma homosisteine levels in patients with ischemic cerebrevascular disease and healthy control subjects. J Lab Clin Med 1999 133 575 82.
35. K ara I S azci A E rgul E et al. Association of the C677T and A1298C polymorphisms in the 5,10-methylenetetrahydrofolate reductase gene in patients with migraine risk. Mol Brain Res 2003 111 84 90.
36. U car F S onmez M O vali E et al. MTHFR C677T polymorphism and its relation to ischemic stroke in the Black Sea Turkish population. Am J Hematol 2004 76 40 3.
37. B alta G Y uksek N O zyurek E et al. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003 73 154 60.
38. A kar N A kar E M isirlioǧlu F et al. Search for genetic factors favoring thrombosis in Turkish population. Thromb Res 1998 92 79 82.
39. H ermann W Q uast S U lrich M et al. Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation. Atherosclerosis 1999 144 91 101.
40. L ievers KJA B oers GHJ V erhoef V et al. A second common variant in methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine and cardiovascular disease risk. J Mol Med 2001 79 522 8.
41. D iaz -A rrastia R. Homocysteine and neurologic disease. Arch Neurol 2000 57 1422 8.
42. K elly PJ B arron M F urie KL. Hyperhomocysteinemia, MTHFR 677C→T polymorphism and stroke. Stroke 2002 33 1452 3.
43. S chmitz C L indpainter K V erhoef P et al. Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. Circulation 1996 94 1812 4.
44. B ailey LB D uhaney RL M aneval DR. Vitamin B-12 status is inversely associated with plasma homosisteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms. J Nutr 2002 132 24665 709.
45. M alinow MR K ang SS T aylor LM et al. Prevalence of hyperhomocyst(e) inemia in patients with peripheral arterial occlusive disease. Circulation 1989 79 1180 8.
46. C leophas TJ H ornstra N V an H oogstraten B et al. Homocysteine, a risk factor for coronary artery disease or not? A meta-analysis. Am J Cardiol 2000 86 1005 9.