In rats chronically treated with clozapine, tyrosine depletion attenuates the clozapine-induced in vivo increase in prefrontal cortex dopamine and norepinephrine levels

Psychopharmacology

Volumn 185, Issue 4, 2006, Pages 416-422

  Jaskiw, George E ^a,b   Kirkbride, Bobbi ^a   Bongiovanni, Rodolfo ^a  

^a LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Clozapine; Dopamine; Medial prefrontal cortex; Norepinephrine; Tyrosine

Indexed keywords

AMINO ACID; CLOZAPINE; DOPAMINE; NORADRENALIN; PHENYLALANINE; PSYCHOTROPIC AGENT; TYROSINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN LEVEL; CANNULA; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; IMPLANTATION; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; STEREOTAXIC SURGERY;

AMINO ACIDS; ANIMALS; ANTIPSYCHOTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOZAPINE; DOPAMINE; MALE; MICRODIALYSIS; NOREPINEPHRINE; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE;

EID: 33645455400     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-0283-1     Document Type: Article

References (62)

1. Akil M, Pierri JN, Whitehead RE, Edgar CL, Mohila C, Sampson AR, Lewis DA (1999) Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. Am J Psychiatry 156:1580-1589
2. Baldessarini RJ, Centorrino F, Flood JG, Volpicelli SA, Huston-Lyons D, Cohen BM (1993) Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 9:117-124
3. Biggio G, Porceddu ML, Gessa GL (1976) Decrease of homovanillic, dihydroxyphenylacetic acid and cyclic-adenosine-3′,5′-monophosphate content in the rat caudate nucleus induced by the acute administration of an aminoacid mixture lacking tyrosine and phenylalanine. J Neurochem 26:1253-1255
4. Blanc G, Herve D, Simon H, Lisoprawski A, Glowinski J, Tassin JP (1980) Response to stress of mesocortico-frontal dopaminergic neurones in rats after long-term isolation. Nature 284:265-267
5. Bongiovanni R, Yamamoto BK, Jaskiw GE (2001) Improved method for the measurement of large neutral amino acids in biological matrices. J Chromatogr B Biomed Sci Appl 754:369-376
6. Bongiovanni R, Kirkbride B, Walmire P, Jaskiw GE (2005) Tyrosine administration does not affect desipramine-induced dopamine levels as measured in vivo in prefrontal cortex. Brain Res 1054(2):203-206
7. Carlsson A, Lindqvist M (1978) Dependence of 5-HT and catecholamine synthesis on precursor amino-acid levels in rat brain. Naunyn Schmiedebergs Arch Pharmacol 303:157-164
8. Chen JP, Ruan D, Paredes W, Gardner EL (1992) Effects of acute and chronic clozapine on dopaminergic function in medial prefrontal cortex of awake, freely moving rats. Brain Res 571:235-241
9. Chung YC, Li Z, Dai J, Meltzer HY, Ichikawa J (2004) Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism. Brain Res 1023:54-63
10. Cooper JR, Bloom FE, Roth RH (2002) The biochemical basis of neuropharmacology, 8th edn. Oxford University Press, New York
11. DePietro FR, Fernstrom JD (1999) The relative roles of phenylalanine and tyrosine as substrates for DOPA synthesis in PC12 cells. Brain Res 831:72-84
12. Deutch AY, Roth RH (1990) The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog Brain Res 85:367-402
13. Devoto P, Flore G, Vacca G, Pira L, Arca A, Casu MA, Pani L, Gessa GL (2003) Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic. Psychopharmacology (Berl) 167:79-84
14. During MJ, Acworth IN, Wurtman RJ (1989) Dopamine release in rat striatum: physiological coupling to tyrosine supply. J Neurochem 52:1449-1454
15. Fairbrother IS, Arbuthnott GW, Kelly JS, Butcher SP (1990) In vivo mechanisms underlying dopamine release from rat nigrostriatal terminals: II. Studies using potassium and tyramine. J Neurochem 54:1844-1851
16. Fernstrom MH, Femstrom JD (1995) Acute tyrosine depletion reduces tyrosine hydroxylation rate in rat central nervous system. Life Sci 57:97-102
17. Fernstrom MH, Volk EA, Fernstrom JD (1984) In vivo tyrosine hydroxylation in the diabetic rat retina: effect of tyrosine administration. Brain Res 298:167-170
18. Fernstrom MH, Baker RL, Fernstrom JD (1989) In vivo tyrosine hydroxylation rate in retina: effects of phenylalanine and tyrosine administration in rats pretreated with p-chlorophenylalanine. Brain Res 499:291-298
19. Fischer V, Schmitt U, Weigmann H, Von Keller B, Reuss S, Hiemke C, Dahmen N (1998) Chronical haloperidol and clozapine treatment in rats: differential RNA display analysis, behavioral studies and serum level determination. Prog Neuropsychopharmacol Biol Psychiatry 22:1129-1139
20. Gessa GL, Devoto P, Diana M, Flore G, Melis M, Pistis M (2000) Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex. Neuropsychopharmacology 22:642-649
21. Gu H, Wall SC, Rudnick G (1994) Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J Biol Chem 269:7124-7130
22. Hernandez L, Hoebel BG (1995) Chronic clozapine selectively decreases prefrontal cortex dopamine as shown by simultaneous cortical, accumbens, and striatal microdialysis in freely moving rats. Pharmacol Biochem Behav 52:581-589
23. Invernizzi R, Pozzi L, Samanin R (1995) Further studies on the effects of chronic clozapine on regional extracellular dopamine levels in the brain of conscious rats. Brain Res 670:165-168
24. Jaskiw GE, Bongiovanni R (2004) Brain tyrosine depletion attenuates haloperidol-induced striatal dopamine release in vivo and augments haloperidol-induced catalepsy in the rat. Psychopharmacology (Berl) 172:100-107
25. Jaskiw GE, Collins KA, Pehek EA, Yamamoto BK (2001) Tyrosine augments acute clozapine- but not haloperidol-induced dopamine release in the medial prefrontal cortex of the rat: an in vivo microdialysis study. Neuropsychopharmacology 25:149-156
26. Jaskiw GE, Simpson C, Bongiovanni R, Yamamoto BK (2004) Tyrosine augments clozapine-induced dopamine release in the medial prefrontal cortex of the rat in vivo: effects of access to food. Neurosci Lett 357:5-8
27. Jaskiw GE, Kirkbride B, Newbould E, Young D, Durkalski V, Bongiovanni R (2005) Clozapine-induced dopamine release in the medial prefrontal cortex is augmented by a moderate concentration of locally administered tyrosine but attenuated by high tyrosine concentrations or by tyrosine depletion. Psychopharmacology (Berl) 179(4):713-724
28. Joh TH, Turk DH, Reis DJ (1978) Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase mechanism and enzyme activation. Proc Natl Acad Sci U S A 75:4744-4748
29. Kandera J, Levi G, Lajtha A (1968) Control of cerebral metabolite levels. II. Amino acid uptake and levels in various areas of the rat brain. Arch Biochem Biophys 126:249-260
30. Kaufman S, Kaufman EE (1985) Tyrosine hydroxylase. In: Blakley RL, Benkovic SJ (eds) Chemistry and biochemistry of the pterins. Wiley, New York, pp 251-352
31. Lindstrom LH, Gefvert O, Hagberg G, Lundberg T, Bergstrom M, Hartvig P, Langstrom B (1999) Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET. Biol Psychiatry 46:681-688
32. Lund-Andersen H (1979) Transport of glucose from blood to brain. Physiol Rev 59:305-352
33. McTavish SF, Callado L, Cowen PJ, Sharp T (1999a) Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo. J Psychopharmacol 13:379-384
34. McTavish SF, Cowen PJ, Sharp T (1999b) Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. Psychopharmacology (Berl) 141:182-188
35. McTavish SF, McPherson MH, Harmer CJ, Clark L, Sharp T, Goodwill GM, Cowen PJ (2001) Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness. Br J Psychiatry 179:356-360
36. Milner JD, Wurtman RJ (1986) Catecholamine synthesis: physiological coupling to precursor supply. Biochem Pharmacol 35:875-881
37. Miner LH, Schroeter S, Blakely RD, Sesack SR (2003) Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals. J Comp Neurol 466:478-494
38. Moghaddam B, Bunney BS (1990) Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study. J Neurochem 54:1755-1760
39. Morgenroth VA, Walters JR, Roth RH (1976) Dopaminergic neurons - alteration in the kinetic properties of tyrosine hydroxylase after cessation of impulse flow. Biochem Pharmacol 25:655-661
40. Morrow BA, Rosenberg SJ, Roth RH (1999) Chronic clozapine, but not haloperidol, alters the response of mesoprefrontal dopamine neurons to stress and clozapine challenges in rats. Synapse 34:28-35
41. Pardridge WM (1977) Regulation of amino acid availability to the brain. In: Wurtman RJ, Wurtman JJ (eds) Nutrition and the brain. Raven, New York, pp 141-204
42. Pardridge WM, Oldendorf WH (1975) Kinetic analysis of blood-brain barrier transport of amino acids. Biochim Biophys Acta 401:128-136
43. Paxinos G, Watson D (1982) The rat brain in stereotaxic coordinates. Academic, New York
44. Pehek EA (1999) Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. J Pharmacol Exp Ther 289:14-23
45. Pehek EA, Yamamoto BK (1994) Differential effects of locally administered clozapine and haloperidol on dopamine efflux in the rat prefrontal cortex and caudate-putamen. J Neurochem 63:2118-2124
46. Rehavi M, Roz N, Weizman A (2002) Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2. Eur Neuropsychopharmacol 12:261-268
47. Scally MC, Ulus IH, Wurtman RJ (1977) Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats. J Neural Transm 43:103-108
48. Scarna A, Gijsman HJ, McTavish SF, Harmer CJ, Cowen PJ, Goodwin GM (2003) Effects of a branched-chain amino acid drink in mania. Br J Psychiatry 182:210-213
49. Schmitt U, Dahmen N, Fischer V, Weigmann H, Rao ML, Reuss S, Hiemke C (1999) Chronic oral haloperidol and clozapine in rats: a behavioral evaluation. Neuropsychobiology 39:86-91
50. Smith QR, Momma S, Aoyagi M, Rapaport SI (1987) Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 49:1651-1658
51. Sved AF, Fernstrom JD (1981) Tyrosine availability and dopamine synthesis in the striatum: studies with gamma-butyrolactone. Life Sci 29:743-748
52. Tejedor-Real P, Faucon BN, Dumas S, Mallet J (2003) Tyrosine hydroxylase mRNA and protein are down-regulated by chronic clozapine in both the mesocorticolimbic and the nigrostriatal systems. J Neurosci Res 72:105-115
53. Verrey F (2003) System L: heteromeric exchangers of large, neutral amino acids involved in directional transport. Pflugers Arch 445:529-533
54. Westerink BHC, Wirix E (1983) On the significance of tyrosine for the synthesis and catabolism of dopamine in rat brain: evaluation by HPLC with electrochemical detection. J Neurochem 40:758-764
55. Westerink BH, De Boer P, De Vries JB, Kruse CG, Long SK (1998) Antipsychotic drugs induce similar effects on the release of dopamine and noradrenaline in the medial prefrontal cortex of the rat brain. Eur J Pharmacol 361:27-33
56. Westerink BH, Kawahara Y, De Boer P, Geels C, De Vries JB, Wikstrom HV, Van Kalkeren A, Van Vliet B, Kruse CG, Long SK (2001) Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum. Eur J Pharmacol 412:127-138
57. Wiesel F-A, Blomqvist G, Halldin C, Sjogren I, Bjerkenstedt L, Venizelos N, Hagenfeldt L (1991) The transport of tyrosine into the human brain as determined with L-[1-11C]tyrosine and PET. J Nucl Med 32:2043-2049
58. Wiesel F-A, Edman G, Eriksson A, Flyckt L, Nyman H, Venizelos N, Bjerkenstedt L (2005) Kinetics of tyrosine transport and cognitive functioning in schizophrenia. Schizophr Res 74(1):81-89
59. Yamamoto BK, Cooperman MA (1994) Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations. J Neurosci 14:4159-4166
60. Yavich L, MacDonald E (2000) Dopamine release from pharmacologically distinct storage pools in rat striatum following stimulation at frequency of neuronal bursting. Brain Res 870:73-79
61. Youngren KD, Moghaddam B, Bunney BS, Roth RH (1994) Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neurosci Lett 165:41-44
62. Youngren KD, Inglis FM, Pivirotto PJ, Jedema HP, Bradberry CW, Goldman-Rakic PS, Roth RH, Moghaddam B (1999) Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus. Neuropsychopharmacology 20:403-412