Transfollicular delivery of linoleic acid in human scalp skin: Permeation study and microautoradiographic analysis

International Journal of Cosmetic Science

Volumn 28, Issue 2, 2006, Pages 117-123

  Raufast, V ^a   Mavon, A ^a,b  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b NONE   (France)

Author keywords

Acne; Linoleic acid; Microautoradiography; Percutaneous absorption

Indexed keywords

LINOLEIC ACID;

ARTICLE; AUTORADIOGRAPHY; CELLULAR DISTRIBUTION; COMPUTER PROGRAM; CONTROLLED STUDY; DERMIS; DRUG DIFFUSION; DRUG PENETRATION; HAIR ANALYSIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MICROAUTORADIOGRAPHY; MOLECULAR MODEL; OPTICAL RESOLUTION; SCALP; SKIN PERMEABILITY; STRATUM CORNEUM;

EID: 33645411668     PISSN: 01425463     EISSN: 14682494     Source Type: Journal    
DOI: 10.1111/j.1467-2494.2006.00303.x     Document Type: Article

References (22)

1. Hartop P.J. Prottey C. Changes in transdermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to skin of essential fatty acid-deficient rats. Br. J. Dermatol. 95 255 264 1976
2. Elias P.M. Brown B.E. Ziboh V.A. The permeability barrier in essential fatty acid deficiency: evidence for a direct role for linoleic acid in barrier function. J. Invest. Dermatol. 74 230 233 1980
3. Ziboh V.A. Chapkin R.S. Biological significance of polyunsatured fatty acids in the skin. Arch. Dermatol. 123 1686a 1690 1987
4. Liang T. Liao S. Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids. Biochem. J. 15 557 562 1992
5. Chen W. Zouboulis C. Orfanos C.E. The 5-alpha reductase system and its inhibitors. Dermatology 193 177 184 1966
6. Akamatsu H. Komura J. Miyachi Y. Asada Y. Niwa Y. Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. J. Invest. Dermatol. 95 271 274 1990
7. Namazi M.R. Further insight into the pathomechanism of acne by considering the 5-α-reductase inhibitory effect of linoleic acid. Int. J. Dermatol. 43 701 702 2004
8. Downie M.M.T. Guy R. Kealey T. Advances in sebaceous gland research: potential new approaches to acne management. Int. J. Cosmet. Sci. 26 291 311 2004
9. Downie M.M.T. Sanders D.A. Maier L.M. Stock D.M. Kealey T. PPAR and FXR ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. Br. J. Dermatol. 151 766 775 2004
10. Hueber F. Schaefer H. Wepierre J. Role of transdermal and transfollicular routes in percutaneous absorption of steroids: in vitro studies on human skin. Skin Pharmacol. 7 237 244 1994
11. Ogiso T. Shiraki T. Okajima K. Tanino T. Iwaki M. Wada T. Transfollicular drug delivery: penetration of drugs through human scalp skin and comparison of penetration between scalp and abdominal skins. J. Drug Target.q12 10 369 378 2002
12. Bidmon H.J. Pitts J.D. Solomon H.F. Bondi J.V. Stumpf W.E. Estradiol distribution and penetration in rat skin after topical application, studied by high resolution autoradiography. Histochemistry 95 43 54 1990
13. Stumpf W.E. Clark S.A. Sar M DeLuca H.F. Topographical and developmental studies on target sites of 1,25(OH)2 vitamin D3 in skin. Cell Tissue Res. 238 489 496 1984
14. Hayakawa N. Kubota N. Imai N. Stumpf W.E. Receptor microscopic autoradiography for the study of percutaneous absorption, in vivo skin penetration, and cellular-intercellular deposition. J. Pharmacol. Toxicol. Methods 50 131 137 2004
15. Roguet R. Lotte C. Rouers D. Dupuis D. Rougier A. Corroller M. et al. In vivo distribution of linoleic acid in hairless rat skin following topical application. Arch. Dermatol. Res. 278 503 506 1986
16. Hoelgaard A. Mollgaard B. Permeation of linoleic acid through skin in vitro. J. Pharm. Pharmacol. 34 610 611 1982
17. Guidance Documents for the Conduct of Skin Absorption Studies OCED series on testing and assessment no. 28. OECD Paris 2004
18. Diembeck W. Grimmert A. In Percutaneous Absorption/Penetration in In Vitro Excised Pig Skin. Cosmetic Ingredients: Guidelines for Percutaneous Absorption/Penetration pp. 24 31. COLIPA Brussels 1995
19. Ohta T. Okabe K. Azuma Y. Kiyoki M. In vivo microautoradiography of tacalcitol following topical application to normal rats and in vitro metabolism in human keratinocytes. Arch. Dermatol. Res. 288 188 196 1996
20. 3H-norethindrone acetate transport across human epidermis as a function of time. Acta. Derm. Venereol. 208 36 43 2000
21. Gautier B. Bernard B.A. On the use of Micro-Imager to directly visualize drug distribution in human skin. Skin Pharmacol. Appl. Skin Physiol. 14 41 45 2001
22. Stumpf W.E. Drug Localization in Tissues and Cells. IDDC-Press