On the use of Micro-Imager® to directly visualize drug distribution in human skin

Skin Pharmacology and Applied Skin Physiology

Volumn 14, Issue SUPPL. 1, 2001, Pages 41-45

  Gautier, B ^a   Bernard, Bruno A ^a  

^a L ORÉAL RECHERCHE   (France)

Author keywords

Autoradiography; Drug distribution; Hair follicle; Micro Imager ; Targetting

Indexed keywords

ARTICLE; CONTROLLED STUDY; DEVICE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG SAFETY; HISTOLOGY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; NORMAL HUMAN; PRIORITY JOURNAL; RADIOACTIVITY; CLINICAL TRIAL; DIFFUSION CHAMBER; EPIDERMIS; HAIR FOLLICLE; IN VITRO STUDY; INSTRUMENTATION; METABOLISM; PHYSIOLOGY; SCINTILLATION COUNTING; SCINTISCANNING; SKIN; SKIN ABSORPTION; VEHICLES;

DRUG; DRUG VEHICLE;

DIFFUSION CHAMBERS, CULTURE; EPIDERMIS; HAIR FOLLICLE; HUMANS; PHARMACEUTICAL PREPARATIONS; SCINTILLATION COUNTING; SKIN; SKIN ABSORPTION; VEHICLES;

EID: 0035733321     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056389     Document Type: Article

References (6)

1. Determination of the horny layer profile by tape stripping in combination with optical spectroscopy in the visible range as a prerequisite to quantify percutaneous absorption
2. Bioavailability of clobetasol propionate. Quantification of drug concentrations in the stratum corneum by dermatopharmacokinetics using tape stripping
3. Standardization of experimental models
4. Localization of compounds in different skin layers and its use as an indicator of percutaneous absorption
5. Quantitative determination of percutaneous absorption of radiolabelled drugs in vitro and in vivo by human skin
6. Polymeric microspheres, as a novel topical site specific drug delivery system for targeting a naphtoic acid derivative, adapalene, to the pilosebaceous unit