Role of transepidermal and transfollicular routes in percutaneous absorption of steroids: In vitro studies on human skin

Skin Pharmacology and Physiology

Volumn 7, Issue 5, 1994, Pages 237-244

  Hueber, F ^a   Schaefer, H ^b   Wepierre, J ^a  

^a Laboratoire de Pharmacologic ^*  (France)

^b Galderma R and D   (France)

Author keywords

Estradiol; Human skin; Hydrocortisone; Percutaneous absorption; Progesterone; Scar skin; Steroids; Testosterone; Transfollicular penetration

Indexed keywords

COLLAGEN FIBRIL; ESTRADIOL; HYDROCORTISONE; PROGESTERONE; STEROID; TESTOSTERONE;

ADULT; ARTICLE; CONTROLLED STUDY; DERMOEPIDERMAL JUNCTION; DOSE TIME EFFECT RELATION; DRUG ACCUMULATION; EPIDERMIS CELL; FEMALE; HAIR FOLLICLE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SEBACEOUS GLAND; SKIN ABSORPTION; SKIN CELL; SKIN SCAR; SKIN SURFACE; TISSUE SECTION; TOPICAL DRUG ADMINISTRATION;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CICATRIX; COMPARATIVE STUDY; ESTRADIOL; FEMALE; HAIR; HUMAN; HYDROCORTISONE; IN VITRO; MIDDLE AGE; PROGESTERONE; SKIN; SKIN ABSORPTION; STAINING AND LABELING; STEROIDS; TESTOSTERONE;

EID: 0028299927     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000211300     Document Type: Article

References (11)

1. Scheuplein RJ: Mechanism of percutaneous absorption. II. Transient diffusion and the relative importance of various routes of skin penetration. J Invest Dermatol 1967;48: 79-88.
2. Scheuplein RJ, Blank IH, Brauner GJ. McFarlane DJ: Percutaneous absorption of steroids. J Invest Dermatol 1969;52:63-70.
3. Behl CR, Bellantone NH, Flynn GL: Influence of age on percutaneous absorption of drug substances; in Bronaugh RL, Maibach HI (eds): Percutaneous Absorption: Mechanism, Methodology. Drug Delivery. New York, Dekker, 1985, pp 183-212.
4. Ritschel WA, Sabouni A, Hussain AS: Percutaneous absorption of cou-marin, griseofulvin and propranolol across human scalp and abdominal skin. Methods Find Exp Clin Pharmacol 1989; 11:643-646.
5. Tur E, Maibach HI, Guy R: Percutaneous penetration of methyl nicoti-natc at three anatomic sites: Evidence for an appcndagcal contribution to transport? Skin Pharmacol 1991;4:230-234.
6. Illel B, Schaefer H: Transfollicular percutaneous absorption: Skin model for quantitative studies. Acta Derm Venereol (Stockh) 1988;68: 427-430.
7. Schaefer H, Watts F, Brod J, Illel B: Follicular penetration; in Scott RC, Guy RH, Hadgraft J (eds): Prediction of Percutaneous Absorption: Methods, Measurements, Modelling. London, IBC Technical Services, 1990, pp 163-173.
8. Wepierre J, Doucct O, Marty JP: Percutaneous absorption of drugs in vitro: Role of transepidermal and transfollicular routes; in Scott RC, Guy RH, Hadgraft J (eds): Prediction of Percutaneous Absorption: Methods, Measurements, Modelling. London, IBC Technical Services, 1990, pp 129-134.
9. Illel B, Schaefer H, Wepierre J. Dou-cet O: Follicles play an important role in percutaneous absorption. J PharmSci 1991;80:424-427.
10. Hueber F, Wepierre J, Schaefer H: Role of transepidermal and transfollicular routes in percutaneous absorption of hydrocortisone and testosterone: In vivo study in the hairless rat. Skin Pharmacol 1992:5:99-107.
11. Szabo G: The regional anatomy of the human integument with special reference to the distribution of hair follicles, sweat glands and melanocytes. Philos Trans Soc B 1967:252: 447-485.