Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic β-cell line

Molecular Endocrinology

Volumn 20, Issue 4, 2006, Pages 844-856

  Kawamura, Yoshihiro ^a   Tanaka, Yasushi ^b   Kawamori, Ryuzo ^b   Maeda, Shiro ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GLUCOSE; GLUCOSE TRANSPORTER 2; HEXOKINASE; INSULIN; INTERLEUKIN 6; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; LEPTIN; SULFONYLUREA RECEPTOR 1; TRANSCRIPTION FACTOR PDX 1;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; INSULIN RELEASE; KRUPPEL LIKE FACTOR 7 GENE; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; CYTOKINES; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; PREGNANCY; RATS; RNA, MESSENGER; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 33645401884     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2005-0138     Document Type: Article

References (25)

1. Matthaei S, Stumvoll M, Kellerer M, Häring HU 2000 Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev 21:585-618
2. Zimmet P, Alberti KG, Shaw J 2001 Global and societal implications of the diabetes epidemic. Nature 414:782-787
3. DeFronzo RA, Bonadonna RC, Ferrannini E 1992 Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15:318-368
4. Kahn BB 1998 Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92:593-596
5. Saltiel AR 2001 New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104:517-529
6. Dang DT, Pevsner J, Yang VW 2000 The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol 32:1103-1121
7. Bieker JJ 2001 Kruppel-like factors: three fingers in many pies. J Biol Chem 276:34355-34358
8. Black AR, Black JD, Azizkhan-Clifford J 2001 Sp1 and Kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 188:143-160
9. Banerjee SS, Feinberg MW, Watanabe M, Gray S, Haspel RL, Denkinger DJ, Kawahara R, Hauner H, Jain MK 2003 The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor expression and adipogenesis. J Biol Chem 278:2581-2584
10. Gray S, Feinberg MW, Hull S, Kuo CT, Watanabe M, Sen-Banerjee S, DePina A, Haspel R, Jain MK 2002 The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem 277:34322-34328
11. Kanazawa A, Kawamura Y, Sekine A, Iida A, Tsunoda T, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kawai K, Iiizumi T, Fujioka T, Imanishi M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S 2005 Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. Diabetologia 48:1315-1322
12. Matsumoto N, Laub F, Aldabe R, Zhang W, Ramirez F, Yoshida T, Terada M 1998 Cloning the cDNA for a new human zinc finger protein defines a group of closely related Kruppel-like transcription factors. J Biol Chem 273:28229-28237
13. Fasshauer M, Paschke R 2003 Regulation of adipocytokines and insulin resistance. Diabetologia 46:1594-1603
14. Orci L, Ravazzola M, Baetens D, Inman L, Amherdt M, Peterson RG, Newgard CB, Johnson JH, Unger RH 1990 Evidence that down-regulation of β-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. Proc Natl Acad Sci USA 87:9953-9957
15. Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir S 1990 Reduced expression of the liver/β-cell glucose transporter isoform in glucose-insensitive pancreatic β cells of diabetic rats. Proc Natl Acad Sci USA 87:6492-6496
16. Ohneda M, Johnson JH, Inman LR, Unger RH 1993 GLUT-2 function in glucose-unresponsive β cells of dexamethasone-induced diabetes in rats. J Clin Invest 92:1950-1956
17. Bonny C, Roduit R, Gremlich S, Nicod P, Thorens B, Waeber G 1997 The loss of GLUT2 expression in the pancreatic β-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors. Mol Cell Endocrinol 135:59-65
18. Jorns A, Tiedge M, Sickel E, Lenzen S 1996 Loss of GLUT2 glucose transporter expression in pancreatic β cells from diabetic Chinese hamsters. Virchows Arch 428:177-185
19. Ohneda M, Johnson JH, Inman LR, Chen L, Suzuki K, Goto Y, Alam T, Ravazzola M, Orci L, Unger RH 1993 GLUT2 expression and function in β-cells of GK rats with NIDDM. Dissociation between reductions in glucose transport and glucose-stimulated insulin secretion. Diabetes 42:1065-1072
20. Guillam MT, Hummler E, Schaerer E, Yeh JI, Birnbaum MJ, Beermann F, Schmidt A, Deriaz N, Thorens B 1997 Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet 17:327-330
21. Miki T, Nagashima K, Tashiro F, Kotake K, Yoshitomi H, Tamamoto A, Gonoi T, Iwanaga T, Miyazaki J, Seino S 1998 Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc Natl Acad Sci USA 95:10402-10406
22. Seghers V, Nakazaki M, DeMayo F, Aguilar-Bryan L, Bryan J 2000 Sur1 knockout mice. A model for K (ATP) channel-independent regulation of insulin secretion. J Biol Chem 275:9270-9277
23. Miki T, Tashiro F, Iwanaga T, Nagashima K, Yoshitomi H, Aihara H, Nitta Y, Gonoi T, Inagaki N, Miyazaki J, Seino S 1997 Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel. Proc Natl Acad Sci USA 94:11969-11973
24. Vestergaard H, Bjorbaek C, Hansen T, Larsen FS, Granner DK, Pedersen O 1995 Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. J Clin Invest 96:2639-2645
25. Guillam M, Burcelin R, Thorens B 1998 Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes. Proc Natl Acad Sci USA 95:12317-12321