A multistep approach to structure-based drug design: Studying ligand binding at the human neutrophil elastase

Journal of Medicinal Chemistry

Volumn 49, Issue 6, 2006, Pages 1837-1844

  Steinbrecher, Thomas ^a   Case, David A ^b   Labahn, Andreas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CINNAMIC ACID; ELASTIN; ESTER DERIVATIVE; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; PROTEINASE; SOLVENT;

ACCURACY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DRUG CONFORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENERGY; HYDROGEN BOND; IC 50; LIGAND BINDING; MOLECULAR DYNAMICS; NEUTROPHIL; SIMULATION; THEORETICAL MODEL; THERMODYNAMICS;

BINDING SITES; CAFFEIC ACIDS; COMPUTER SIMULATION; COUMARIC ACIDS; DRUG DESIGN; HUMANS; LEUKOCYTE ELASTASE; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLACETATES; PROTEIN BINDING; THERMODYNAMICS;

EID: 33645400172     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0505720     Document Type: Article

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