Hyperacute rejection in ex vivo-perfused porcine lungs transgenic for human complement regulatory proteins

Transplant International

Volumn 19, Issue 3, 2006, Pages 225-232

  Pöling, Jochen ^a   Oezkur, Mehmet ^a   Kogge, Karina ^a   Mengel, Michael ^a   Niemann, Heiner ^b   Winkler, Michael ^a   Haverich, Axel ^a   Wiebe, Karsten ^a,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b INSTITUT FÜR TIERZUCHT   (Germany)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Complement inhibition; Lung perfusion; Transgenic organs; Xenotransplantation

Indexed keywords

CD59 ANTIGEN; COMPLEMENT COMPONENT C1S INHIBITOR; DECAY ACCELERATING FACTOR; REGULATOR PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HYPERACUTE GRAFT REJECTION; LUNG FUNCTION; LUNG SEQUESTRATION; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; NONHUMAN; OXYGENATION; PARENCHYMA; PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; SURVIVAL; SWINE; THROMBOCYTE; TRANSGENICS; XENOGRAFT;

ACUTE DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD55; ANTIGENS, CD59; BLOOD PLATELETS; COMPLEMENT C1 INHIBITOR PROTEIN; GRAFT REJECTION; HUMANS; LUNG; LUNG TRANSPLANTATION; OXYGEN; PARTIAL PRESSURE; PERFUSION; SWINE; TIME FACTORS; TRANSGENES; TRANSPLANTATION, HETEROLOGOUS;

EID: 33645349054     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2006.00267.x     Document Type: Article

References (32)

1. Platt JL Fischel RJ Matas AJ Reif SA Bolman RM Bach FH. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model Transplantation 1991 52 214
2. Bucher P Morel P Buhler LH. Xenotransplantation: an update on recent progress and future perspectives Transpl Int 2005 18 894
3. Macchiarini P Mazmanian GM Oriol R et al. Ex vivo lung model of pig-to-human hyperacute xenograft rejection J Thorac Cardiovasc Surg 1997 114 315
4. Pierson RN III. Kasper-Konig W Tew DN et al. Hyperacute lung rejection in a pig-to-human transplant model: the role of anti-pig antibody and complement Transplantation 1997 63 594
5. Mollnes TE Fiane AE. Perspectives on complement in xenotransplantation Mol Immunol 2003 40 135
6. Schmoeckel M Bhatti FN Zaidi A et al. Orthotopic heart transplantation in a transgenic pig-to-primate model Transplantation 1998 65 1570
7. Schuurman HJ Pino-Chavez G Phillips MJ Thomas L White DJ Cozzi E. Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors Transplantation 2002 73 1146
8. Yeatman M Daggett CW Parker W et al. Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthotopic single lung transplant models Transplantation 1998 65 1084
9. Gaca JG Lesher A Aksoy O et al. Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation Transplantation 2002 73 1717
10. Gonzalez-Stawinski GV Daggett CW Lau CL et al. Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation J Am Coll Surg 2002 194 765
11. Kulick DM Salerno CT Dalmasso AP et al. Transgenic swine lungs expressing human CD59 are protected from injury in a pig-to-human model of xenotransplantation J Thorac Cardiovasc Surg 2000 119 690
12. Ward PA. Recruitment of inflammatory cells into lung: roles of cytokines, adhesion molecules, and complement J Lab Clin Med 1997 129 400
13. Cantu E Parker W Platt JL Duane Davis R. Pulmonary xenotransplantation: rapidly progressing into the unknown Am J Transplant 2004 4 Suppl. 6 25
14. Nguyen BH Zwets E Schroeder C Pierson III RN. Azimzadeh AM. Beyond antibody-mediated rejection: hyperacute lung rejection as a paradigm for dysregulated inflammation Curr Drug Targets Cardiovasc Haematol Disord 2005 5 255
15. Yeatman M Daggett CW Lau CL et al. Human complement regulatory proteins protect swine lungs from xenogeneic injury Ann Thorac Surg 1999 67 769
16. Daggett CW Yeatman M Lodge AJ et al. Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model J Thorac Cardiovasc Surg 1997 113 390
17. Pfeiffer S Zorn III GL. Blair KS et al. Hyperacute lung rejection in the pig-to-human model 4: evidence for complement and antibody independent mechanisms Transplantation 2005 79 662
18. Azimzadeh A Zorn III GL. Blair KS et al. Hyperacute lung rejection in the pig-to-human model. 2. Synergy between soluble and membrane complement inhibition Xenotransplantation 2003 10 120
19. Kirschfink M Mollnes TE. C1-inhibitor: an anti-inflammatory reagent with therapeutic potential Expert Opin Pharmacother 2001 2 1073
20. Cozzi E Tucker AW Langford GA et al. Characterization of pigs transgenic for human decay-accelerating factor Transplantation 1997 64 1383
21. Niemann H Verhoeyen E Wonigeit K et al. Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection Transplantation 2001 72 1898
22. Fischer S Matte-Martyn A De Perrot M et al. Low-potassium dextran preservation solution improves lung function after human lung transplantation J Thorac Cardiovasc Surg 2001 121 594
23. Schroder C Pfeiffer S Wu G et al. Effect of complement fragment 1 esterase inhibition on survival of human decay-accelerating factor pig lungs perfused with human blood J Heart Lung Transplant 2003 22 1365
24. Fiane AE Videm V Johansen HT Mellbye OJ Nielsen EW Mollnes TE. C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model Immunopharmacology 1999 42 231
25. Sims PJ Wiedmer T. The response of human platelets to activated components of the complement system Immunol Today 1991 12 338
26. Collins BJ Blum MG Parker RE et al. Thromboxane mediates pulmonary hypertension and lung inflammation during hyperacute lung rejection J Appl Physiol 2001 90 2257
27. Pfeiffer S Zorn III GL. Zhang JP et al. Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury Transplantation 2003 75 953
28. Chen G Sun QY Wang XM et al. Improved suppression of circulating complement does not block acute vascular rejection of pig-to-rhesus monkey cardiac transplants Xenotransplantation 2004 11 123
29. Leventhal JR Dalmasso AP Cromwell JW et al. Prolongation of cardiac xenograft survival by depletion of complement Transplantation 1993 55 857 discussion 865
30. Nottle MB D'Apice AJ Cowan PJ Boquest AC Harrison SJ Grupen CG. Transgenic perspectives in xenotransplantation, 2001 Xenotransplantation 2002 9 305
31. Fecke W Long J Richards A Harrison R. Protection of hDAF-transgenic porcine endothelial cells against activation by human complement: role of the membrane attack complex Xenotransplantation 2002 9 97
32. Lau CL Daggett WC Yeatman MF et al. The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants J Thorac Cardiovasc Surg 2000 120 29